- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05074524
Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings
May 16, 2022 updated by: Hyunhwa Lee, University of Nevada, Las Vegas
Evaluating Repetitive Transcranial Magnetic Stimulation to Reduce Opioid Cravings in Adults Who Use Heroin
The purpose of this research study is to test the effect of repetitive transcranial magnetic stimulation (rTMS) on opioid cravings among adult patients with Opioid Use Disorder.
Study Overview
Status
Completed
Detailed Description
This study will use rTMS, a neuromagnetic and non-invasive treatment, to reduce opioid cravings in individuals who are diagnosed with opioid use disorder.
Repetitive transcranial magnetic stimulation is currently used for the treatment of Major Depressive Disorder and Obsessive Compulsive Disorder in clinical practice.
This proposed study will employ a randomized, single-blind, experimental design.
Participants will be randomly assigned to two groups using a computer-based randomization program: treatment and sham-control groups.
Study Type
Interventional
Enrollment (Actual)
24
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Nevada
-
Las Vegas, Nevada, United States, 89154
- University of Nevada, Las Vegas
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 64 years (ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Adult aged 18-64, used heroin in the past 30 days;
- has a history of heroin use for at least one year;
- meets the clinical criteria for Opioid Use Disorder (only heroin use will be considered to meet this criteria);
- meets the clinician clearance using the rTMS Patient Screening Form.
Exclusion Criteria:
- do not currently take and medications for a substance use disorder such as methadone, buprenorphine, naltrexone, acamprosate, disulfiram;
- do not have a psychotic disorder;
- do not have a diagnosis of another substance use disorder;
- do not have a history of seizures or other neurological disorders including organic brain disease; epilepsy, stroke, brain lesions, multiple sclerosis, previous neurosurgery;
- do not have a personal history of head trauma that resulted in a loss of consciousness for more than 5 minutes and retrograde amnesia for more than 30 minutes;
- do not have a presence of non-fixed metal in body 30 cm to treatment coil.
- have not taken any medication for a substance use disorder within the last 72 hours before the first rTMS treatment;
- are not pregnant or think you may be pregnant.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: SINGLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: rTMS group
Active rTMS treatment will be delivered at 10 Hz, 100% resting motor threshold, 2000 pulses delivered in five seconds per train with 10-second intra-train pause, delivered once daily five days per week, Monday through Friday for 10 days (10 total treatments).
This protocol is adapted from Shen and colleagues (2016), who did not report any adverse events.
Liu and colleagues (2020) also used the same protocol and only reported mild side effects of dizziness, headache, and insomnia, which resolved by the 30-day follow-up.
However, it is unclear whether these side effects resolved sooner than the 30-day follow-up.
|
Active rTMS treatment will be delivered at 10 Hz, 100% resting motor threshold, 2000 pulses delivered in five seconds per train with 10-second intra-train pause, delivered once daily five days per week, Monday through Friday for 10 days (10 total treatments).
This protocol is adapted from Shen and colleagues (2016), who did not report any adverse events.
Liu and colleagues (2020) also used the same protocol and only reported mild side effects of dizziness, headache, and insomnia, which resolved by the 30-day follow-up.
However, it is unclear whether these side effects resolved sooner than the 30-day follow-up.
|
SHAM_COMPARATOR: Placebo Group
The control group will undergo the same seat positioning and comfort measures but will not have a resting motor threshold determination.
The coil will be turned 90 degrees counter-clockwise, and the side of the coil will rest on the scalp over the area of the skull corresponding to the motor cortex, so the participant will feel the coil making contact.
The same treatment protocol in the active rTMS group will be initiated to mimic the sound of rTMS treatment, though no pulses will be delivered to the participant because of the coil rotation.
|
The control group will undergo the same seat positioning and comfort measures but will not have a resting motor threshold determination.
The coil will be turned 90 degrees counter-clockwise, and the side of the coil will rest on the scalp over the area of the skull corresponding to the motor cortex, so the participant will feel the coil making contact.
The same treatment protocol in the active rTMS group will be initiated to mimic the sound of rTMS treatment, though no pulses will be delivered to the participant because of the coil rotation.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Desires for Drug Questionnaire
Time Frame: Days 1, 3, 5, 8, 10, 12, 42
|
This standardized questionnaire measures cravings for opioids.
This scale includes a total of 13 items.
Scoring is based on a 1-7 likert scale for each item.
Specific items are assigned to one of three domains: desire, negative reinforcement, and control.
A higher score indicates higher level of cravings.
A lower score indicates a lesser level of opioid cravings, which is a better outcome.
The primary outcome measure will be measured at various time points throughout the study to assess a change.
|
Days 1, 3, 5, 8, 10, 12, 42
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
October 6, 2021
Primary Completion (ACTUAL)
January 24, 2022
Study Completion (ACTUAL)
January 24, 2022
Study Registration Dates
First Submitted
July 30, 2021
First Submitted That Met QC Criteria
October 6, 2021
First Posted (ACTUAL)
October 12, 2021
Study Record Updates
Last Update Posted (ACTUAL)
May 17, 2022
Last Update Submitted That Met QC Criteria
May 16, 2022
Last Verified
May 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1748113-2
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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