Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.

September 7, 2023 updated by: Shanghai Jiao Tong University School of Medicine

Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.

To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.

  1. The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.
  2. The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.
  3. The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.

Study Type

Observational

Enrollment (Estimated)

800

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Hainan
      • Sanya, Hainan, China
        • Recruiting
        • Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
        • Contact:
        • Principal Investigator:
          • Shijian Liu, Ph.D

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

3 years to 80 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

  1. 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atypical dermatitis from northeast China.
  2. 3-12 years-old children with asthma, allergic rhinitis, atypical dermatitisin in Sanya.

Description

Inclusion Criteria:

  • 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
  • 3-12 years-old children in Sanya;
  • Agree to participate this study.

Exclusion Criteria:

  • Disagree to participate this study;
  • Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
  • Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Migratory old people with asthma from northern China in Sanya
Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Migratory old people with allergic rhinitis from northern China in Sanya
Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya
Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Migratory old people with atopic dermatitis from northern China in Sanya
Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Children with asthma in Sanya
Children with asthma have being exposure to tropical climate and environment in Sanya for years.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Children with allergic rhinitis in Sanya
Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Children with atopic dermatitis in Sanya
Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Children with eczema in Sanya
Children with eczema have being exposure to tropical climate and environment in Sanya for years.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Children with urticaria in Sanya
Children with urticaria have being exposure to tropical climate and environment in Sanya for years.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Migratory old people with eczema from northern China in Sanya
Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
Migratory old people with urticaria from northern China in Sanya
Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Other: Climate and environment in Sanya
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.
Time Frame: 3 year
The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire..
3 year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Asthma control of migratory old people with asthma.
Time Frame: 1-3 year
Quality of life is assessed through questionnaires of "Asthma Control Questionnaire (ACQ) ".
1-3 year
Asthma life quality of migratory old people with asthma.
Time Frame: 1-3 year
Quality of life is assessed through questionnaires of "Asthma Quality of Life Questionnaire (AQLQ)".
1-3 year
Lung function of migratory old people with asthma or COPD.
Time Frame: 1-3 year
Lung function is assessed through simple lung function test using spirometry.
1-3 year
The respiratory function of migratory old people with COPD.
Time Frame: 1-3 year
Lung function is assessed through Saint George Respiratory Questionnaire (SGRQ).
1-3 year
Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Time Frame: 1-3 year
Veinal blood was extracted to detect allergens.
1-3 year
Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Time Frame: 1-3 year
Inflammatory factors such as esophageal granulocytes and eosinophils will be detected to assess inflammatory status of the migratory old people.
1-3 year
The change of asthma incidence rate in migratory old people .
Time Frame: 1-3 year
Diagnosis and severity grading of asthma is based on the "American Thoracic Society" or the "National Heart, Lung, and Blood Institute guidelines."
1-3 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shanghai Jiao Tong University School of Medicine

Investigators

  • Principal Investigator: Shijian Liu, Ph.D, Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 3, 2022

Primary Completion (Estimated)

December 31, 2023

Study Completion (Estimated)

April 30, 2025

Study Registration Dates

First Submitted

March 18, 2022

First Submitted That Met QC Criteria

April 8, 2022

First Posted (Actual)

April 15, 2022

Study Record Updates

Last Update Posted (Actual)

September 11, 2023

Last Update Submitted That Met QC Criteria

September 7, 2023

Last Verified

September 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SYFYIRB2022009

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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