Effects of Yoga on Sodium-induced Pressor Responses in African American Adults

Effects of Yoga on Pressor and Endothelial Function in Responses to Sodium Loading in African American Adults

This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.

Study Overview

• Status: Completed
• Conditions: Blood Pressure
• Intervention / Treatment: Behavioral: Yoga; Behavioral: Waitlist control

• Study Type: Interventional
• Enrollment (Actual): 15
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Texas
    • San Marcos, Texas, United States, 78666
      • Cardiovascular Physiology Laboratory-Texas State University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• African American
• Adults ages 18-60 years

Exclusion Criteria:

• pregnancy or within 60 days postpartum
• having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation);
• infection (viral or other) within the past 4 weeks;
• having adrenal or endocrine tumors (these could impact BP);
• renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated);
• prior myocardial infarction; vii) known coronary heart disease;
• personal history of stroke;
• heart failure;
• cardiac arrhythmias;
• chronic obstructive pulmonary disease;
• recent chest pain or dyspnea;
• orthopedic limitations that preclude the execution of yoga postures;
• current insulin dependence;
• currently taking steroid medications;
• currently undergoing chemotherapy or radiation;
• having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months;
• heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Yoga; Yoga sessions (35 minutes each) will be performed 5 times weekly for 4 weeks.	Behavioral: Yoga; Yoga sessions will be completed 5 times per week for 4 weeks.
Other: Waitlist control; Waitlisted participants will maintain their normal diet and exercise patterns for 4 weeks prior to rerandomization to the yoga group.	Behavioral: Waitlist control; Waitlisted participants will maintain their normal exercise and diet for 4 weeks. After follow up testing at week 4, participants will be rerandomized to the yoga condition.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in blood pressure from low- to high-sodium dietary conditions	Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake.	Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.
Change in endothelial function from low- to high-sodium dietary conditions.	Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
Change in arterial stiffness from low- to high-sodium dietary conditions.	Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in urinary sodium excretion from low- to high-sodium dietary conditions.	24-hour urine collection will be completed after 3 days of low- and after 3 days of high-sodium dietary conditions.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

Collaborators and Investigators

• Sponsor: Texas State University

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2021
• Primary Completion (Actual): July 1, 2022
• Study Completion (Actual): July 1, 2022

Study Registration Dates

• First Submitted: April 25, 2022
• First Submitted That Met QC Criteria: April 25, 2022
• First Posted (Actual): April 29, 2022

Study Record Updates

• Last Update Posted (Actual): April 10, 2024
• Last Update Submitted That Met QC Criteria: April 9, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: Blood pressure; Salt sensitivity
• Other Study ID Numbers: 7620

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No