Prevention of Postpartum Hemorrhage With Tranexamic Acid (Optimum OB-TXA)

Prevention of Postpartum Hemorrhage: Pharmacokinetics (PK) Abd Pharmacodynamics (PD) of Tranexamic Acid

In part 1 of the study, the investigators conducted a prospective, open-label, dose finding pharmacokinetic (PK) study in 43 pregnant 3rd trimester women scheduled for non-emergent cesarean section.

The investigators administered three doses of the drug (5 mg/kg, 10 mg/kg and 15 mg/kg) in an escalating fashion by cohort with the lowest dose first. The drug was administered intravenously at the time of umbilical cord clamping for a non-emergent cesarean section. A maximum of 1 g was administered. TXA serum levels at several time points after delivery were assayed to see if they reach the target plasma concentration of 10 ug/mL. A PK model was constructed for determining the optimal TXA dose administered at parturition.

In part 2 of the study, the investigators aim to compare PKPD endpoints using prophylactic TXA via IV and IM routes administered pre-cord clamp. The investigators will administer 1 g TXA within 10 minutes of skin incision via intravenous infusion (up to n=15), intravenous bolus < 2 minutes (up to n=15) and intramuscular injection (up to n=15). The investigators will target women undergoing scheduled cesarean delivery > 34 weeks gestation, women undergoing vaginal delivery > 34 weeks of gestation and morbidly obese women (BMI>=40) undergoing either a vaginal or cesarean delivery. The investigators will use advanced modeling techniques to determine time to achieve PKPD targets and duration remaining at those targets. The goal will be to determine how the optimal dose may vary if route of administration is modified. The investigators plan to enroll 45 patients in addition to the 43 that were enrolled during part 1. Our goal is to 30 participants, but the investigators will enroll 45 to account for lost to follow-up. The investigators also aim to enroll 30 patients undergoing vaginal delivery and 30 morbidly obese women (BMI >= 40) undergoing either a vaginal or cesarean delivery but the investigators will enroll 45 patients for each of these groups to account for loss to follow up. In addition, the investigators will enroll 30 pregnant patients receiving no medication acting as the control group, but the investigators will enroll 45 to account for loss to follow up.

Study Overview

• Status: Recruiting
• Conditions: Post Partum Hemorrhage
• Intervention / Treatment: Drug: Tranexamic acid; Drug: Tranexamic acid; Drug: Tranexamic acid; Other: No intervention

Detailed Description

The study will enroll 45 additional third trimester pregnant women scheduled for nonemergent cesarean sections. The investigators plan to enroll 30, but to account for lost to follow-up, the investigators will enroll 45. The investigators will also enroll 30 pregnant patients > 34 weeks of gestation undergoing vaginal delivery, and 30 morbidly obese (BMI >= 40) pregnant patients undergoing either vaginal or cesarean delivery. However, the investigators will enroll 45 patients in each of these two groups to account for loss to follow up. The investigators will also enroll 45 patients as a control group that will not receive TXA. The total number of enrolled patients will thus be 223.

A total of 1 g of TXA will be administered to patients prior to fetal delivery via three different routes of administration: IV infusion, IV push, and IM injection. The subjects in each group will be divided into three subgroups:

Group 1: Up to 15 subjects, TXA dose: 1 g, Route: IV infusion over 10 minutes Group 2: Up to 15 subjects, TXA dose: 1 g, Route: IV Push for <2 minutes Group 3: Up to 15 subjects, TXA dose: 1 g, Route: IM Injection

Plasma sampling: Timing of samples will be relative to the end of drug administration (t = 0) and include: Pre-drug administration, 5-10 minutes, 30-60 minutes, 60-90 minutes, 1.5-3 hours, 3-4 hours, 4-5 hours, 7-8 hours, and 10-18 hours. Each volume of blood draw will be approximately 7-9 mL. Actual times of plasma sampling will be documented. A second IV will be required for participating in the study. Citrated plasma samples will be centrifuged and supernatant will be stored at -80 degree Celsius. Breast milk sampling of no more than 2 mL per time point will occur at time points coinciding with maternal feedings.

• Study Type: Interventional
• Enrollment (Estimated): 120
• Phase: Phase 2

Contacts and Locations

• Study Contact: Name: Homa K Ahmadzia, MD; Phone Number: 706-776-6650; Email: homa.ahmadzia@inova.org
• Study Contact Backup: Name: Jaclyn Phillips

Study Locations

• United States
  • District of Columbia
    • Washington D.C., District of Columbia, United States, 20037
      • Recruiting
      • George Washington University Hospital
      • Contact: Jaclyn Phillips, MD; Phone Number: 202-741-2500; Email: japhillips@mfa.gwu.edu
      • Sub-Investigator: Homa K Ahmadzia, MD
      • Principal Investigator: Jaclyn Phillips, MD
  • Virginia
    • Falls Church, Virginia, United States, 22042
      • Recruiting
      • Inova Fairfax Medical Campus
      • Principal Investigator: Homa Ahmadzia, MD
      • Contact: Homa Ahmadzia, MD; Phone Number: 706-776-6650; Email: homa.ahmadzia@inova.org

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Women who are scheduled to under medically indicated cesarean section at greater than 34+0 weeks gestation or women who are scheduled to undergo an elective cesarean section at 39+0 weeks gestation in accordance with recommendations from the American Congress of Obstetricians and Gynecologists
• Women who are indicated to have a vaginal delivery at > 34+0 weeks gestation.
• Pregnant women with normal serum creatinine (serum creatinine < 0.9) within 2 weeks of estimated/scheduled delivery
• Women between the ages of 18 and 50 years old
• Ability to understand and the willingness to sign a written informed consent form and HIPAA Authorization.

Exclusion Criteria:

• active thrombotic or thromboembolic disease
• a history of arterial or venous thromboembolic event
• inherited thrombophilia or preexisting conditions that predisposes them to thromboembolic events (i.e. lupus, antiphospholipid syndrome, thrombocytosis or thrombophilic thrombocytopathy)
• a subarachnoid hemorrhage
• acquired defective color vision
• history of seizure disorder
• known renal dysfunction (serum creatinine = or >0.9)
• multiple gestations (twin or triplet pregnancies)
• hypersensitivity to Tranexamic acid or anti-fibrinolytic therapy
• history of liver dysfunction at the discretion of the investigator

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Cesarean Delivery	Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via infusion over 10 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via push over 2 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intramuscularly.; Other: No intervention; Control group with no administration of Tranexamic Acid.
Experimental: Vaginal Delivery	Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via infusion over 10 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via push over 2 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intramuscularly.; Other: No intervention; Control group with no administration of Tranexamic Acid.
Experimental: Morbidly Obese	Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via infusion over 10 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intravenously via push over 2 minutes.; Drug: Tranexamic acid; Tranexamic Acid 1000 mg administered intramuscularly.; Other: No intervention; Control group with no administration of Tranexamic Acid.
No Intervention: No TXA

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
PK Model Parameter Estimates	Data obtained from assays of TXA in blood, dose group and patient characteristics; parameter estimates in 2 compartment model includes the clearance of the drug (L/hr).	Different time points ranging from surgery (T0) to 1 day postpartum.
Pharmacodynamics of Tranexamic Acid	PD model parameters included concentration of TXA causing 50% of maximal fractional inhibition (IC50).	Different time points ranging from surgery (T0) to 1 day postpartum.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Estimated Blood Loss	Intraoperative blood loss	During surgery
Safety Parameters	Safety parameters such as adverse events (including nausea/vomiting) and serious adverse events	During surgery, after surgery while in hospital, 2 weeks and 6 weeks postpartum

Collaborators and Investigators

• Sponsor: Inova Health Care Services
• Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); University of Maryland; George Washington University; University of North Carolina
• Investigators: Principal Investigator: Homa K Ahmadzia, MD, Inova Health Care Services

Study record dates

Study Major Dates

• Study Start (Actual): December 28, 2022
• Primary Completion (Estimated): November 15, 2026
• Study Completion (Estimated): June 1, 2027

Study Registration Dates

• First Submitted: April 22, 2022
• First Submitted That Met QC Criteria: May 6, 2022
• First Posted (Actual): May 12, 2022

Study Record Updates

• Last Update Posted (Actual): March 27, 2026
• Last Update Submitted That Met QC Criteria: March 23, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Urogenital Diseases; Pathologic Processes; Female Urogenital Diseases and Pregnancy Complications; Obstetric Labor Complications; Pregnancy Complications; Hemorrhage; Puerperal Disorders; Uterine Hemorrhage; Pathological Conditions, Signs and Symptoms; Postpartum Hemorrhage; Organic Chemicals; Carboxylic Acids; Acids, Carbocyclic; Cyclohexanecarboxylic Acids; Tranexamic Acid
• Other Study ID Numbers: INOVA-2024-39; R01HD110109 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No