Clinical Characteristics, Management Patterns and Outcomes of Type A Aortic Dissection: A Sino-US Comparative Cohort Analysis

This study constructed a retrospective cohort study by retrospectively analyzing the data of all patients with aortic dissection from January 1, 2012 to December 31, 2021 from the Cardiovascular Disease Registration System of Jiangsu Province in China and the data of similar diseases in recent years from National Inpatient Sample database in the United States

Study Overview

• Status: Completed
• Conditions: Aortic Dissection
• Intervention / Treatment: Procedure: surgery

• Study Type: Observational
• Enrollment (Actual): 11550

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All patients with aortic dissection in Jiangsu Aortic Registry system of China from January 2012 to December 2021 and all patients with aortic dissection in National Inpatient Sample database of the United States from January 2015 to December 2019.

Description

Inclusion Criteria:

1.Clinical diagnosis of type A Aortic Dissection

Exclusion Criteria:

1. age<18, age unknown,
2. diagnosis of aortic aneurysm, transfer out within 1 day,
3. unknown vital status at discharge;
4. unknown treatment type: cardioplegia, valve or cardiac repair only without aortic repair or two types of treatments on different days

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Chinese patients with aortic dissection; Clinical characteristics, management patterns and outcomes of type A aortic dissection in China.	Procedure: surgery; surgery on patients with aortic dissection
American patients with aortic dissection; Clinical characteristics, management patterns and outcomes of type A aortic dissection in the United States.	Procedure: surgery; surgery on patients with aortic dissection

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Baseline data of patients with type A aortic dissection was assessed by SPSS 17.0	Baseline data of patients with type A aortic dissection included gender, age,height, weight, past medical history, family history, hospital costs, etc.	from 2015 to 2019
The main efficacy indicators was assessed by SPSS 17.0.	The main efficacy indicators included surgical procedures, surgical outcome (postoperative bleeding, ICU stay, extubation time), perioperative complications (including infection, bleeding, neurological complications, cardic complications, renal insufficiency, etc.), and postoperative mortality.	from 2015 to 2019

Collaborators and Investigators

• Sponsor: Xin Chen
• Collaborators: China Medical University, China

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2012
• Primary Completion (Actual): December 1, 2021
• Study Completion (Actual): December 1, 2021

Study Registration Dates

• First Submitted: May 20, 2022
• First Submitted That Met QC Criteria: June 5, 2022
• First Posted (Actual): June 8, 2022

Study Record Updates

• Last Update Posted (Actual): June 8, 2022
• Last Update Submitted That Met QC Criteria: June 5, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Keywords: China; Aortic Dissection; the United States
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Aneurysm; Aneurysm, Dissecting
• Other Study ID Numbers: NanjingFirst AAD

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No