- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05419440
Laparoscopic Drainage Versus Interventional Radiology In Management Of Appendicular Abscess :
Laparoscopic Drainage Versus Interventional Radiology In Management Of Appendicular Abscess : A Randomized Controlled Trial.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This prospective randomized controlled clinical trial included all patients who developed the manifestations of appendicular abscess and referred to the Zagazig University Hospital Emergency Department between January 2020 and February 2022. The study was prospectively approved by Zagazig University Faculty of Medicine Institutional Review Board (Approval Number: 55342/24.1.2020), and was retrospectively submitted in clinicaltrials.gov in September 2021 (NCT05051683). The study was performed in accordance with the code of ethics of the World Medical Association (Declaration of Helsinki) for studies involving human subjects. Written informed consent was obtained from all participants after explaining to them all the study procedures with its benefits and hazards. Patients ≥16- ≤60 years-old, with appendicular abscess , with early sepsis , no septic shock , ASA I & II , no other pathology and candidate for laparoscopy were deemed eligible for randomization. We excluded patients who were <16- >60 years-old, septic shock, appendicular mass, ASA III , previous abdominal operations, immune compromised patients , patients with immune suppressive therapy, pregnant patients and not candidate for laparoscopy.
Involved patients were simply randomized at a 1:1 ratio to "laparoscopic Group (LG)" or "Interventional Radiology Group (IG)" via the drawing of sealed envelopes containing computer-generated random numbers prepared by a third party before the start of the procedure.
The sample size was calculated by using open Epi program depending on the following data ; confidence interval 95%, power of the test 80%, ratio of unexposed/exposed 1, percent of patients with complications after management of appendicular abscess by interventional radiology 15 %, and those managed by laparoscopy 2 % , odds ratio 8.7 , and risk ratio 7.5, So the calculated sample size equal 172 patients divided into two equal group.
Primary and secondary outcomes were fecal fistula , recurrent collection and quality of life in each group after the procedures during the 3-months follow-up period, respectively.
Diagnosis After full history taking ( throbbing pain at right iliac fossa several days ago ) and complete physical examination ( fluctuant high grade fever especially at evening , severe pain & tenderness at right iliac fossa , toxic manifestations), appendicular abscess was clinically suspected and then confirmed by laboratory investigations (complete blood picture (WBC count more than 16000), liver and kidney functions, coagulation profile), radiological imaging (abdominal US or CT abdomen with oral and I.V contrast confirms appendicular abscess) , in laparoscopic group we exclude patients with other pathology after laparoscopic exploration However, the radiology finding was consistent with appendicular abscess.
Intervention For laparoscopic group ( included 86 patients ) , the patients were subjected to the following steps after the diagnosis has been confirmed as appendicular abscess. The patients were taken rapidly to operative theater , general anesthesia was given , patients were put in supine position , sterilization of the abdomen from subcostal margin to pubic bone was done , ports insertion was done , one 10 mm port supra-umbilical , one 5mm port at left iliac fossa , one 5mm port at right iliac fossa , insertion of the 10 mm port was done first by open method or versus needle , insufflation of co2 up to 14 mm.hg was done after 10 mm port insertion , exploration of the abdomen first by 10 mm telescope , to exclude other pathology and confirm the diagnosis ( we exclude patients with other pathology after laparoscopic exploration ) , then insertion of other two ports under vision , removal of any adhesions first , irrigation & suction whole the abdomen first with warm saline 0.9% , access to caecum by tilting the table head down and to left to pull all intestine away from caecum , access to caecum and remove any adhesions with surrounding by sharp & blunt dissection , then access to appendicular abscess by sharp and blunt dissection , drain all the pus by suction , irrigation with warm saline , after complete separation of the appendix from surrounding & complete drainage of pus & removal of all necrotic tissue , removal of the remnant appendix , in cases with healthy base of appendix ,we closed the stump with endo-loop , in case with unhealthy base , we closed the stump by suturing by ethibond 2/0 in two layers in case with little edema & inflammation of caecum ( sutures not cut through ) , in cases with marked edema and inflammation of caecum , we close the site of base by omental patch fixed by taking full thickness sutures in wall of caecum and pass through omental patch , we examine any leak by pressing on caecum and observe any fecal matter comes & air leak test , in all cases we made irrigation & suction with 2000cc warm saline and put large drain at pelvis to be removed later according to its discharge , deflation of the abdomen and close the port sites. Then patients were kept in hospital under observation till drain removal.
For interventional radiology group ( included 86 patients ) , patients were subjected for drain insertion or pig catheter insertion at right iliac fossa under a complete sterilized filed by radiologist , then daily wash from drain or pig catheter by gentamycin & metronidazole till drain discharge comes clear fluid , then drain removed according the amount of discharge and doing us confirm there is no residual.
Statistical analysis Analysis of data was performed using SPSS (Statistical Package of Social Services) version 22. Quantitative variables were described as mean (±SD, standard deviation) and median (range) according to Shapiro test of normality. Qualitative variables were described as a number and a percent. Chi-square test was used to compare qualitative variables between the 2 groups. Fisher exact test was used when one expected cell or more are less than 5. Unpaired t-test was used to compare quantitative variables, in parametric data (SD < 30% of the mean). Mann Whitney test was used instead of unpaired t-test in non-parametric data (SD > 30% of the mean). The results were considered statistically significant when the significant probability was less than 0.05 (P < 0.05). P-value < 0.001 was considered highly statistically significant (HS), and P-value ≥ 0.05 was considered statistically insignificant (NS).
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Sharquia
-
Zagazig, Sharquia, Egypt, 1185
- Zagazig University Hospitals
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients ≥16- ≤60 years-old with appendicular abscess
- with early sepsis.
- no septic shock.
- ASA I & II.
- no other pathology .
- candidate for laparoscopy .
Exclusion Criteria:
- <16- >60 years-old .
- septic shock.
appendicular mass.
*, ASA III .
- previous abdominal operations.
- immune compromised patients .
- patients with immune suppressive therapy.
- pregnant patients not
- candidate for laparoscopy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: laparoscopic drainage of appendicular abscess
laparoscopic drainage of appendicular abscess laparoscopy drainage of pus ,excision of appendix and putting a drain
|
access to caecum and remove any adhesions with surrounding by sharp & blunt dissection , then access to appendicular abscess by sharp and blunt dissection after complete separation of the appendix from surrounding & complete drainage of pus & removal of all necrotic tissue , removal of the remnant appendix , in cases with healthy base of appendix ,we closed the stump with endo-loop , in case with unhealthy base , we closed the stump by suturing by ethibond 2/0 in two layers in case with little edema & inflammation of caecum ( sutures not cut through ) , in cases with marked edema and inflammation of caecum , we close the site of base by omental patch fixed by taking full thickness sutures in wall of caecum and pass through omental patch , we examine any leak by pressing on caecum and observe any fecal matter comes & air leak test , in all cases we put large drain at pelvis
|
No Intervention: interventional radiology for management of appendicular abscess
insertion of a drain or pig tail under sonar or ct guided
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
incidence of complications after laparoscopic drainage of appendicular abscess
Time Frame: within one week after laparoscopic drainage of the appendicular abscess
|
incidence of complications after laparoscopic drainage of appendicular abscess
|
within one week after laparoscopic drainage of the appendicular abscess
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
incidence of mortality after laparoscopic drainage of appendicular abscess
Time Frame: within one month after laparoscopic drainage of appendicular abscess
|
incidence of mortality after laparoscopic drainage of appendicular abscess
|
within one month after laparoscopic drainage of appendicular abscess
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Said Mohamed Negm, MD, Zagazig University Hospitals
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- General Surgery Departement
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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