Is Sheep Ghee Cardioprotective?

August 5, 2022 updated by: Javad Kojuri, Shiraz University of Medical Sciences

Effect of Sheep Ghee on Lipid Profile and High-sensitivity C-reactive Protein: A Randomized Clinical Trial

Normal volunteers were randomly received Sheep ghee or sunflower oil, and before and after the study lipid profile and HS-CRP were measured.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

During outpatient clinic visits, potentially eligible individuals were screened for enrollment according to the inclusion and exclusion criteria.

Patients were randomly allocated into the treatment and control groups via the blocked randomization method.

The control group received a normal diet for eight weeks with 10 g of sunflower oil. In the treatment group, sunflower oil was replaced with 10 g of sheep ghee.

50 patients in each group were enrollment. Patients' information, including demographic data and the serum levels of fasting blood sugar (FBS), LDL, HDL, triglyceride (TG), and hs-CRP, were recorded in datasheets twice: once before treatment with sheep ghee and once eight weeks later.

Study Type

Interventional

Enrollment (Actual)

50

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 76 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • healthy adults, seeking outpatient visit at professor kojuri cardiology clinic

Exclusion Criteria:

  • any history of ischemic heart disease (IHD),
  • coronary artery bypass grafting (CABG)
  • percutaneous intervention (PCI)
  • stroke
  • peripheral vascular diseases
  • use of anti-hyperlipidemic agents
  • unwillingness to participate.
  • Need of tight hyperlipidemia control.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: intervention
10 gr Sheep ghee
Dietary supplement: sheep ghee
natural sheep ghee, given to patient in a commercial box and intervention group 10 gr per day from sheep ghee
Active Comparator: control group
10 gr sunflower oil
Dietary supplement: sunflower oil
natural sunflower oil, given to patients in a commercial box and patient use 10 gr of it

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
LDL cholesterol
Time Frame: 2 months
serum LDL level in mg/dl
2 months
total cholesterol
Time Frame: 2 months
serum total cholesterol in mg/dl
2 months
HDL cholesterol
Time Frame: 2 months
Serum HDL in mg/dl
2 months
HS-CRP
Time Frame: 2 months
HS-CRP level in picogram/dl
2 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
adverse effect
Time Frame: 2 months
gastrointestinal, skin, allergy
2 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shiraz University of Medical Sciences

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2020

Primary Completion (Actual)

June 1, 2022

Study Completion (Actual)

July 1, 2022

Study Registration Dates

First Submitted

August 5, 2022

First Submitted That Met QC Criteria

August 5, 2022

First Posted (Actual)

August 8, 2022

Study Record Updates

Last Update Posted (Actual)

August 8, 2022

Last Update Submitted That Met QC Criteria

August 5, 2022

Last Verified

August 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 98-01-01-22054

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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