Functional MRI Evaluation in Pyeloureteral Junction Syndrome in Children

August 10, 2022 updated by: Charles Mazeaud, Central Hospital, Nancy, France

Functional MRI Usage for Pyelo-ureteral Junction Syndrome : Results of Nancy Children Hospital Cohort

Pyelo-ureteral junction syndrome is the most common urological abnormality in children.

Functional MRI has been evaluated several times, and had shown good correlation with scintigraphy, but tends to over estimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessel is limited.

We aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function.

Our secondary objectives are : evaluation of MRI performances to detect polar vessel ; comparison of surgery times depending of MRI only realisation or MRI and scintigraphy realisation.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

270

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
    • Lorraine
      • Vandœuvre-lès-Nancy, Lorraine, France, 54 511
        • CHRU Nancy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 day to 17 years (CHILD)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Children between 0 and 17 years old followed for pyelo-ureteral junction syndrome in the Children hospital of Nancy.

Description

Inclusion Criteria:

  • children between 0 and 17 years old
  • followed for pyelo-ureteral junction syndrome

Exclusion Criteria:

  • none

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
PUJS patients
Patients between 0 and 17 years old treated or followed for pyelo-ureteral junction syndrome.
Diagnostic test: Functional MRI
Anatomical MRI : T2 fiesta, SSFE, HASTE ; 3D T2 ; T1 FAT SAT ; LAVA Functional MRI : T1 FAT SAT with gadolinium
Other Names:
  • Renal Scintigraphy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
MRI and scintigraphy differential renal function correlation
Time Frame: from january 2007 to december 2021
Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient
from january 2007 to december 2021

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
MRI and scintigraphy differential renal function correlation in operated patient
Time Frame: from january 2007 to december 2021
Evaluation of differential renal function between MRI and scintigraphy in children operated for PUJS; Pearson correlation coefficient
from january 2007 to december 2021
Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation
Time Frame: from january 2007 to december 2021
Comparison between the mean time between MRI and surgery, and mean time between MRI, scintigraphy and surgery
from january 2007 to december 2021
performance of MRI in detecting polar vessel
Time Frame: from january 2007 to december 2021
Polar vessel : comparison between MRI results and operatory observation, sensitivity et specificity analysis
from january 2007 to december 2021

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Investigators

  • Principal Investigator: Charles Mazeaud, CHRU Nancy

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ANTICIPATED)

September 1, 2022

Primary Completion (ANTICIPATED)

September 15, 2022

Study Completion (ANTICIPATED)

December 30, 2022

Study Registration Dates

First Submitted

August 10, 2022

First Submitted That Met QC Criteria

August 10, 2022

First Posted (ACTUAL)

August 12, 2022

Study Record Updates

Last Update Posted (ACTUAL)

August 12, 2022

Last Update Submitted That Met QC Criteria

August 10, 2022

Last Verified

August 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022PI108

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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