Are Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Systemic Immune Inflammation Score Values Indicators for Postoperative Pain?

November 20, 2023 updated by: Senay Canikli, Samsun University
Postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.

Study Overview

Status

Completed

Conditions

Detailed Description

Subject Researched:

Postoperative pain is a result of the inflammatory response to surgical trauma. Local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. With the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. During the inflammatory response, the level of leukocytes in the blood also changes. Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR) and Systemic immune inflammation score (SII) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. In this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated

Study Type

Observational

Enrollment (Actual)

2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Samsun, Turkey
        • Samsun University
      • Samsun, Turkey
        • Samsun University Samsun Training and Research Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Probability Sample

Study Population

Patients who have undergone elective laparoscopic cholecystectomy

Description

Inclusion Criteria:

  1. Patients aged 18-75 years who underwent elective laparoscopic cholecystectomy.
  2. Patients with ASA status1-2-3

Exclusion Criteria:

  1. Emergency operated patients
  2. Patients switched to open surgery
  3. Patients allergic to tramadol
  4. Those allergic to paracetamol
  5. Those allergic to tenoxicam
  6. Patients who cannot use the patient-controlled analgesia device
  7. Those with hematological disorders
  8. Those receiving immunosuppressive therapy
  9. Those with inflammatory disease
  10. Those with gastrointestinal tumors
  11. Those with rheumatic disease
  12. Those with uncontrolled diabetes
  13. Those with chronic organ failure
  14. Those who use corticosteroids
  15. Opioid users
  16. Those who have recently had an attack of cholecystitis, pancreatitis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
postoperative analgesic consumption
Time Frame: 24 hours
24 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
postoperative pain score
Time Frame: 24 hours
NRS 0-10 point
24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Samsun University

Investigators

  • Study Director: Şenay Canikli Adıgüzel, responsibl investigator

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 18, 2022

Primary Completion (Actual)

September 23, 2022

Study Completion (Actual)

September 24, 2022

Study Registration Dates

First Submitted

September 24, 2022

First Submitted That Met QC Criteria

September 27, 2022

First Posted (Actual)

September 28, 2022

Study Record Updates

Last Update Posted (Actual)

November 22, 2023

Last Update Submitted That Met QC Criteria

November 20, 2023

Last Verified

November 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022/4/11

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

individual participant data will not be shared

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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