Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects (AQ2MF)

May 22, 2025 updated by: Centre Hospitalier Universitaire, Amiens

Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological

The facial palsy is a frequent disease with a lot of etiologies. It has variable severities with sometimes heavy functional repercussions and different recovery potentials. The proposed treatments are based on surgery, physiotherapy and botulinum toxin injections. However, when recovery is incomplete, acceptance is more difficult, with an impacted quality of life. Thanks to Motion Capture and Electromyography, a quantification of the facial mimicry is now possible with a great precision. In addition with the quantification of the facial mimicry, eye-tracking, wich is widely used in the marketing field, but it also finds medical applications including head and neck lesions and facial palsy in particular, will be used to evaluate the visio of the patients on their pathology in function of the movement quantification measured with MoCap and Electromyography. The aim of this research is to measure in a combined way the action potentials by sEMG and the amplitudes of displacement of the markers in motion capture, for movements determined in a population of patients presenting a facial pathology, in order to compare them with reference values obtained in healthy subjects. In a second step, the aim will be to study if there is a link between the way the patient looks at his pathology and the results of his management (treatment, rehabilitation) which will be quantitatively evaluated thanks to MoCap and sEMG.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

720

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
    • Picardie
      • Amiens, Picardie, France, 80054
        • Recruiting
        • CHU Amiens Picardie
        • Sub-Investigator:
          • François-Régis Sarhan, DR
        • Sub-Investigator:
          • Emilien COLIN, Dr
        • Sub-Investigator:
          • Félix Marcellin, Dr
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Subjects with no known facial pathology (healthy volunteers) OR
  • Patients with peripheral facial palsy, irrespective of grade, whether or not previously treated
  • Subject with written informed consent
  • Subject over 18 years of age
  • Subject affiliated to a social security scheme

Exclusion Criteria:

  • Subjects with severe skin disorders that do not allow the application of electrodes or photo reflective markers
  • Subjects with speech disorders making it impossible to pronounce the sounds [o] and [pu]
  • Subject unable to provide written informed consent
  • Subjects under guardianship, curators or safeguard of justice

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: patients with facial palsy
Other: dental impressions
dental impressions
Other: Simultaneous MoCap and EMG acquisition
Simultaneous MoCap and EMG acquisition
Other: Eye-tracking acquisition for pathological subjects
Eye-tracking acquisition for pathological subjects
Other: Follow-up visit for pathological subjects
Follow-up visit for pathological subjects
Active Comparator: healthy volunteers
Other: dental impressions
dental impressions
Other: Simultaneous MoCap and EMG acquisition
Simultaneous MoCap and EMG acquisition

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
determination of baseline values of facial mimicry (in millimetres) in healthy volunteers
Time Frame: one month
determination of baseline values of facial mimicry (in millimetres) in healthy volunteers
one month
determination of baseline values of eye-tracking (in millimetres) in healthy volunteers
Time Frame: one month
determination of baseline values of eye-tracking (in millimetres) in healthy volunteers
one month
determination of the maximum range of motion of facial mimicry (in millimetres) in patients
Time Frame: one year
determination of the maximum range of motion facial mimicry (in millimetres) in patients
one year
determination of the maximum range of motion of eye-tracking (in millimetres) in patients
Time Frame: one year
determination of the maximum range of motion of eye-tracking (in millimetres) in patients
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire, Amiens

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 12, 2022

Primary Completion (Estimated)

October 1, 2027

Study Completion (Estimated)

October 1, 2028

Study Registration Dates

First Submitted

October 12, 2022

First Submitted That Met QC Criteria

October 13, 2022

First Posted (Actual)

October 14, 2022

Study Record Updates

Last Update Posted (Actual)

May 28, 2025

Last Update Submitted That Met QC Criteria

May 22, 2025

Last Verified

May 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PI2021_843_0207

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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