ADL and CONUT for Predicting 1-year Mortality Risk in Older Adults After Hip Fracture

Beijing Tongren Hospital, Capital Medical University

Hip fracture has a serious impact on the quality of life and even the survival of older adults. The multidisciplinary management of hip fracture has been shown to be effective in improving patient outcome and cost-effective in international studies. As geriatricians and members of a multi-disciplinary team（MDT）, we are aware of various scores in predicting the 1-year mortality risk in hospitalized older adults with multimorbidity. However, given the need for a deeper understanding of the preoperative status of elderly patients who were suffering from pain, tension, anxiety, delirium,etc., we hope to explore a simple, quick, objective, and accurate method for assessing the status of elderly patients with hip fractures to predict their survival risk.

Study Overview

• Status: Recruiting
• Conditions: All-cause Mortality
• Intervention / Treatment: Other: no intervention

Detailed Description

This was a single-center retrospective cohort study which were approved by the Clinical Research Ethics Committee of Beijing Tongren Hospital, Capital Medical University (TREC2023-KY026). Demographic characteristics and medical parameters, such as age, gender, body mass index (BMI), comorbidities, hemoglobin , lymphocytes, C-reactive protein (CRP), fasting blood glucose, creatinine, total protein, albumin, triglycerides, total cholesterol and American Association of Anesthesiologists (ASA) were collected from the electronic medical record system. Controlling nutritional status (CONUT) was calculated from 3 variables: serum albumin concentration, total cholesterol concentration, and lymphocyte count, as previously reported. All enrolled patients were followed-up in an outpatients setting. Survival data were obtained via direct contact with patients or patients' caregiver by their physicians at the hospital , or via telephone interview of their family by dedicated coordinators and investigators. The follow-up lasted for one year and the last follow-up was ended on December 31, 2022. All analyses were performed using SPSS version 19.0 (SPSS, Chicago, IL, USA).

• Study Type: Observational
• Enrollment (Estimated): 303

Contacts and Locations

• Study Contact: Name: YING CHEN; Phone Number: 008613621247560; Email: trchenying@mail.ccmu.edu.cn

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100730
      • Recruiting
      • Beijing Tongren Hospital, Capital Medical University
      • Contact: Ying Chen

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Older adults with unilateral hip fractures who received surgical treatment in our hospital from January 2014 to December 2021 were enrolled.

Description

Inclusion Criteria:

1. patients aged ≧65 years old;
2. patients diagnosed with hip fracture, including femoral neck fracture, femoral intertrochanteric fracture, and femoral subtrochanteric fracture;
3. patients whose injury was within 21 days of presentation.

Exclusion Criteria:

1. patients aged <65 years old;
2. patients with pathological fractures due to tumor metastasis or infection or inherited bone disorder;
3. patients with avascular necrosis of femoral head;
4. patients with periprosthetic fractures;
5. old fracture patients treated more than 21 days from injury;
6. patients with severe trauma or fracture in other parts;
7. patients and their families who could not bear the surgical risk and are unwilling to receive surgical treatment;
8. patients died in hospital.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Death by 1 y; patients who dieded within 1-year after discharge due to hip fracture surgery	Other: no intervention; no intervention
Alive at 1 y; patients who survived 1-year after discharge due to hip fracture surgery	Other: no intervention; no intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	After discharge, all enrolled patients were followed-up in an outpatients setting. Survival data were obtained via direct contact with patients or patients' caregiver by their physicians at the hospital , or via telephone interview of their family by dedicated coordinators and investigators. Survival data were obtained via direct contact with patients or patients' caregiver by their physicians at the hospital , or via telephone interview of their family by dedicated coordinators and investigators. Outcomes were recorded.	Calculated from the time of discharge, each patient was followed up 1 year, all-cause death in 1 year after discharge was counted.

Collaborators and Investigators

• Sponsor: Beijing Tongren Hospital
• Investigators: Study Director: QI LIU, Beijing Tongren Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): October 1, 2023
• Primary Completion (Estimated): November 1, 2023
• Study Completion (Estimated): November 1, 2023

Study Registration Dates

• First Submitted: March 19, 2023
• First Submitted That Met QC Criteria: April 3, 2023
• First Posted (Actual): April 14, 2023

Study Record Updates

• Last Update Posted (Actual): October 31, 2023
• Last Update Submitted That Met QC Criteria: October 30, 2023
• Last Verified: March 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: TREC2023-KY026

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No