Comparison of Lumbar Muscle Thickness Measurements in Osteoporotic and Osteopenic Patients

In osteoporosis, sarcopenia is a common condition. Sarcopenic measurements can be made by evaluating muscle thickness in different regions. We aim to evaluate lumbar muscle losses in patients with osteoporosis in the lumbar region and to examine whether these muscle losses are correlated with the level of osteoporosis. The patients will be divided into 3 groups as healthy, osteopenic and osteoporotic according to DEXA measurements. Demographic values, comorbidities, osteoporosis drugs used, fracture histories, L1-4, L2-4, femoral neck and total BMD and t values of the patients, psoas and multifidus muscle measurements will be made at L2-L3 level in Lumbar MR imaging. Lumbar MR muscle measurements will be made by 1 physician blind to the DEXA values of the patients.

Study Overview

• Status: Completed
• Conditions: Osteoporosis
• Intervention / Treatment: Diagnostic test: Lomber Muscle Thickness Measurement

• Study Type: Observational
• Enrollment (Actual): 301

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey, 34100
    • Etfal Training and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

50-90 years old osteoporotic, osteopenic and healthy people

Description

Inclusion Criteria:

• 50-90 years old
• 2. Recent MRI of the lumbar region with DEXA evaluation

Exclusion Criteria:

• Have had previous lumbar surgery
• Any previous lumbar injection
• Stage 3-4 Lumbar Listesis
• Presence of Lumbar Discopathy accompanied by neurological deficit

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Ostoporotic Patients Group; T value of -2.5 and below in DEXA measurement	Diagnostic test: Lomber Muscle Thickness Measurement; Muscle thickness measurements will be made on the imaging of those who have lumbar MR imaging.
Osteopenic Patients Group; T value between -2.5 and -1 in DEXA measurement	Diagnostic test: Lomber Muscle Thickness Measurement; Muscle thickness measurements will be made on the imaging of those who have lumbar MR imaging.
Healthy Group; T value of -1 and above in DEXA measurement	Diagnostic test: Lomber Muscle Thickness Measurement; Muscle thickness measurements will be made on the imaging of those who have lumbar MR imaging.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lomber Muscle Measurement	Psoas and multifidus muscle measurements will be made at L2-L3 level in Lumbar MR imaging.	Day 1

Collaborators and Investigators

• Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Study record dates

Study Major Dates

• Study Start (Actual): August 15, 2023
• Primary Completion (Actual): August 15, 2024
• Study Completion (Actual): August 30, 2024

Study Registration Dates

• First Submitted: April 10, 2023
• First Submitted That Met QC Criteria: April 10, 2023
• First Posted (Actual): April 21, 2023

Study Record Updates

• Last Update Posted (Estimated): November 4, 2024
• Last Update Submitted That Met QC Criteria: November 1, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Bone Diseases, Metabolic; Osteoporosis
• Other Study ID Numbers: 10042023

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No