- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05828485
Effect of Food on Pharmacokinetics of MY008211A Tablets in Healthy Adult Subjects
April 13, 2023 updated by: Wuhan Createrna Science and Technology Co., Ltd
A Single-dose, Open-label Clinical Study to Evaluate the Effect of Food on Pharmacokinetics of MY008211A Tablets in Healthy Adult Subjects
This was a single-center, single-dose, open-label clinical study.
12 subjects were randomly assigned in a 1:1 ratio to one of the following dosing sequences (sequence 1: AB; Sequence 2: BA).
Each dosing sequence consisted of two cycles, one dose per cycle, with a 5-day washout period between doses.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
A: A single dose of MY008211A tablets was administered in the fasting state (fasting for at least 10 h with water as needed).
B: A single dose of MY008211A tablets was administered after a standard high-fat, high-calorie fed.
Study Type
Interventional
Enrollment (Actual)
12
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Hunan
-
Changsha, Hunan, China, 410011
- The Third Hospital of Changsha
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- 18≤ age ≤ 45, male or female;
- Body weight: ≥50 kg for male, ≥45 kg for female; body mass index (BMI): 19.0-26.0 kg/m2 (inclusive);
- Informed consent will be signed before the trial, and the content, process and possible adverse reactions of the trial will be fully understood;
- The volunteers should be able to communicate well with the researchers and understand and comply with the requirements of the study.
Exclusion Criteria:
- Participants who were enrolled in a clinical trial or used a study drug within 3 months before administration of the study drug;
- Patients with chronic or active gastrointestinal diseases such as esophageal disease, gastritis, gastric ulcer, enteritis, active gastrointestinal bleeding, or gastrointestinal surgery within the past three years and still clinically relevant according to the investigator;
- Patients with definite diseases of the central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, hematological system, metabolic system and other diseases that require medical intervention or are not suitable for clinical trial (such as psychiatric history);
- History of known or suspected immunodeficiency (e.g., history of frequent recurrent infections), inherited or acquired complement deficiency;
- Patients had a clear history of capsular microbial infection within 6 months before screening; Including but not limited to: Streptococcus pneumoniae, Bacillus anthracis, Salmonella, Salmonella typhi, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, Neisseria meningitidis, Haemophilus influenzae, Legionella pneumophila infection history;
- Patients with previous or current history of TB infection;
- Active systemic bacterial, viral, or fungal infection within 14 days before administration of the study drug;
- Fever (≥ 38 ° C) within 7 days before administration of the study drug;
- Those who have a history of allergy to the trial preparation and any of its components or related preparations, or to drugs, foods or other substances;
- Those who cannot tolerate intravenous puncture or have a history of syncope or needle sickness;
- Patients who underwent surgery within 6 months before the study drug is used, which will be judged by the investigators to affect the absorption, distribution, metabolism, and excretion of the study drug; Surgical procedures within 4 weeks before the use of the study drug; Or planned to undergo a surgical procedure during the trial;
- Who had taken any medicine (including Chinese herbal medicine, health products, etc.) within 14 days before administration of the study drug;
- Who received a vaccine or live attenuated vaccine within 14 days before administration of the study drug, or who plan to receive a vaccine during the trial;
- Who donated blood or lost a large amount of blood (> 400mL) within 3 months before administration of the study drug, received a blood transfusion or use of blood products, or intended to donate blood or blood components during or within 3 months after administration of the study drug;
- Drug abusers or had used hard drugs (e.g., cocaine, phencyhexidine, etc.) or soft drugs (e.g., cannabis) within 1 year before administration of the study drug;
- Smokers or had smoked more than 5 cigarettes per day in 3 months before study drug use, or will be unable to stop using any tobacco products during the study;
- Heavy drinkers, who drink at least twice a day or more than 14 times a week, or are avid binge drinkers (one drink is defined as 125mL of wine, 220mL of beer, or 50mL of liquor; Binge drinking is defined as 5 or more drinks in approximately 2 hours); Or unwillingness to stop drinking alcohol or any alcohol-based product during the trial;
- Those who have special requirements for diet and cannot abide by the uniform diet;
- Volunteers (or their partners) who plan to be pregnant or donate sperm or eggs during the trial to 3 months after the end of the trial, or who are unwilling to take one or more non-drug contraceptive measures (such as complete abstinence, condoms, contraceptive rings, surgical sterilization, etc.);
- Pregnant or lactating women; Or having unprotected sex within 2 weeks before using the study drug; Or oral contraceptive use within 30 days or long-acting estrogen or progestin injectable or implant use within 6 months before use of the study drug;
- Physical examination, electrocardiogram, chest X-ray, abdominal ultrasound, vital signs, laboratory examination abnormalities were clinically significant (subject to clinician's judgment);
- With positive uremic screening test;
- With positive alcohol breath test;
- Volunteers may not be able to complete the study for other reasons or have other reasons for not participating in the study as judged by the investigator.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Sequence 1 : AB
6 subjects were given a single dose of MY008211A tablets in the fasting state and, after a 5-day washout period, a single dose of MY008211A tablet was administered after taking a standard high-fat and high-calorie fed.
|
A single dose of MY008211A tablet was administered after fasting and high-fat, high-calorie feeding
Other Names:
|
Experimental: Sequence 1 : BA
6 subjects were given a single dose of MY008211A tablet after taking a standard high-fat and high-calorie fed and, after a 5-day washout period, a single dose of MY008211A tablet in the fasting state.
|
A single dose of MY008211A tablet was administered after fasting and high-fat, high-calorie feeding
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Maximum Plasma Concentration (Cmax)
Time Frame: up to 72 hours postdose
|
Maximum Plasma Concentration (Cmax) Of MY008211A tablets
|
up to 72 hours postdose
|
The Maximum Plasma Concentration (Tmax)
Time Frame: up to 72 hours postdose
|
Time To Reach The Maximum Plasma Concentration (Tmax) Of MY008211A
|
up to 72 hours postdose
|
Area Under The Concentration Versus Time Curve (AUC)
Time Frame: up to 72 hours postdose
|
Area Under The Concentration Versus Time Curve (AUC) Of MY008211A
|
up to 72 hours postdose
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The incidence and severity of adverse events to assess safety and tolerability
Time Frame: up to 9 days
|
such as laboratory abnormalities
|
up to 9 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Chair: Wei feng, Ph.D, Wuhan Createrna Science and Technology Co., Ltd
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 26, 2022
Primary Completion (Actual)
October 23, 2022
Study Completion (Actual)
October 23, 2022
Study Registration Dates
First Submitted
April 13, 2023
First Submitted That Met QC Criteria
April 13, 2023
First Posted (Actual)
April 25, 2023
Study Record Updates
Last Update Posted (Actual)
April 25, 2023
Last Update Submitted That Met QC Criteria
April 13, 2023
Last Verified
February 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MY008211-1-03
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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