Posterior Circulation ASTRAL Prognostic Score

April 3, 2025 updated by: George Ntaios, University of Thessaly

Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event <3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Greece
    • Central Macedonia
      • Thessaloniki, Central Macedonia, Greece, 54636
        • First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki
  • Switzerland
    • Vaud canton
      • Lausanne, Vaud canton, Switzerland, 1011
        • Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The participants included in this study are exclusively patients with acute ischemic stroke of the posterior circulation arriving at the hospital within 24h since last proof of good health. These patients must have a modified Rankin Score <3 prior the event and available data concerning: age, NIHSS, glucose levels at admission, mRS prior to event and 3 months after the event and acute phase imaging characteristics (CT and/or MRI) including large vessel occlusion, leukoaraiosis and ASPECTS score from the acute CT scan.

Description

Inclusion Criteria:

  • Isolated posterior circulation strokes based on clinical or/and imaging evidence.
  • Arriving within 24h at hospital since last proof of good health.

Exclusion Criteria:

  • no available data for 3 months modified Rankin Score
  • modified Rankin Score≥3 prior the event

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
ASTRAL
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Basel cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Berlin cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Bern Cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Bologna cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Dijon cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Lisbon cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Israel cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Innsbruck cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
St. Gallen cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Lugano cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Chicago cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
West Virginia cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Zurich cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score
Seoul cohort
Diagnostic test: ASTRAL prognostic score
ASTRAL prognostic score

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
3 months modified Ranking scale
Time Frame: January 2003-December 2021
evaluation of 3 months neurological disability
January 2003-December 2021

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Thessaly

Collaborators

Centre Hospitalier Universitaire Vaudois
University of Lausanne

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2003

Primary Completion (Actual)

December 31, 2021

Study Completion (Estimated)

November 24, 2025

Study Registration Dates

First Submitted

June 6, 2023

First Submitted That Met QC Criteria

June 6, 2023

First Posted (Actual)

June 15, 2023

Study Record Updates

Last Update Posted (Actual)

April 8, 2025

Last Update Submitted That Met QC Criteria

April 3, 2025

Last Verified

April 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • pc-ASTRAL

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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