An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) (CAMBRIA-2)

June 24, 2026 updated by: AstraZeneca

CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease

Study Overview

Status

Recruiting

Conditions

Breast Cancer, Early Breast Cancer

Intervention / Treatment

Detailed Description

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm of the study is 7 years. Eligible patients must have intermediate-high or high risk of recurrence as defined by specified clinical and biologic criteria. Concurrent use of abemaciclib is permitted in both arms. The primary endpoint of the study is Invasive breast cancer-free survival (IBCFS) and main secondary endpoints include Invasive disease-free survival (IDFS), Distant relapse-free survival (DRFS), Overall survival (OS), Safety and Clinical Outcome Assessments (COAs).

Patients will be followed for 10 years from randomization of the last patient.

Study Type

Interventional

Enrollment (Estimated)

5500

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: AstraZeneca Clinical Study Information Center
Phone Number: 1-877-240-9479
Email: information.center@astrazeneca.com

Study Contact Backup

Name: AstraZeneca Breast Cancer Study Locator Service
Phone Number: 1-877-400-4656
Email: az-bcsl@careboxhealth.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1417
    - Withdrawn
    - Research Site
  - CABA, Argentina, C1061
    - Recruiting
    - Research Site
  - Capital Federal, Argentina, 1118
    - Recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, 1426
    - Recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, C1025ABI
    - Recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, C1426ANZ
    - Recruiting
    - Research Site
  - Córdoba, Argentina, X5800HHW
    - Recruiting
    - Research Site
  - Córdoba, Argentina, 5001
    - Recruiting
    - Research Site
  - La Plata, Argentina, 1900
    - Active, not recruiting
    - Research Site
  - Rosario, Argentina, 2123
    - Recruiting
    - Research Site
  - San Juan, Argentina, 5400
    - Active, not recruiting
    - Research Site
  - San Miguel de Tucumán, Argentina, 4000
    - Recruiting
    - Research Site
  - San Miguel de Tucumán, Argentina, T4000IAK
    - Withdrawn
    - Research Site
  - Viedma, Argentina, R8500ACE
    - Recruiting
    - Research Site
Australia
- - Adelaide, Australia, 5081
    - Withdrawn
    - Research Site
  - Bankstown, Australia, 2200
    - Recruiting
    - Research Site
  - Bendigo, Australia, 3550
    - Recruiting
    - Research Site
  - Bowral, Australia, 2576
    - Recruiting
    - Research Site
  - Brighton, Australia, 3186
    - Recruiting
    - Research Site
  - Clayton, Australia, 3168
    - Recruiting
    - Research Site
  - Coffs Harbour, Australia, 2450
    - Recruiting
    - Research Site
  - Fitzroy, Australia, 3065
    - Recruiting
    - Research Site
  - Frankston, Australia, 3199
    - Recruiting
    - Research Site
  - Garran, Australia, 2605
    - Recruiting
    - Research Site
  - Gateshead, Australia, 2290
    - Recruiting
    - Research Site
  - Heidelberg, Australia, 3084
    - Recruiting
    - Research Site
  - Liverpool, Australia, 2170
    - Recruiting
    - Research Site
  - Melbourne, Australia, 3004
    - Recruiting
    - Research Site
  - Murdoch, Australia, WA6150
    - Recruiting
    - Research Site
  - Randwick, Australia, 2031
    - Recruiting
    - Research Site
  - Richmond, Australia, 3121
    - Recruiting
    - Research Site
  - Shepparton, Australia, 3630
    - Recruiting
    - Research Site
  - South Brisbane, Australia, 4101
    - Recruiting
    - Research Site
  - St Leonards, Australia, 2065
    - Recruiting
    - Research Site
  - Subiaco, Australia, 6008
    - Recruiting
    - Research Site
  - Traralgon, Australia, 3844
    - Withdrawn
    - Research Site
  - Wangaratta, Australia, 3677
    - Recruiting
    - Research Site
  - Waratah, Australia, 2298
    - Recruiting
    - Research Site
  - Warnnambool, Australia, 3280
    - Recruiting
    - Research Site
  - Wollongong, Australia, 2500
    - Recruiting
    - Research Site
Austria
- - Graz, Austria, 8036
    - Recruiting
    - Research Site
  - Innsbruck, Austria, 6020
    - Recruiting
    - Research Site
  - Klagenfurt, Austria, 9020
    - Withdrawn
    - Research Site
  - Linz, Austria, 4021
    - Recruiting
    - Research Site
  - Linz, Austria, 4010
    - Recruiting
    - Research Site
  - Salzburg, Austria, 5020
    - Recruiting
    - Research Site
  - Sankt Veit an der Glan, Austria, 9300
    - Recruiting
    - Research Site
  - Steyr, Austria, 4400
    - Recruiting
    - Research Site
  - Vienna, Austria, 1090
    - Recruiting
    - Research Site
  - Vienna, Austria, 1160
    - Recruiting
    - Research Site
  - Vienna, Austria, 1180
    - Withdrawn
    - Research Site
  - Vienna, Austria, 1130
    - Recruiting
    - Research Site
  - Wels, Austria, 4600
    - Recruiting
    - Research Site
  - Wiener Neustadt, Austria, 2700
    - Recruiting
    - Research Site
Belgium
- - Aalst, Belgium, 9300
    - Recruiting
    - Research Site
  - Anderlecht, Belgium, 1070
    - Recruiting
    - Research Site
  - Brasschaat, Belgium, 2930
    - Recruiting
    - Research Site
  - Brussels, Belgium, 1200
    - Recruiting
    - Research Site
  - Charleroi, Belgium, 6000
    - Recruiting
    - Research Site
  - Edegem, Belgium, 2650
    - Recruiting
    - Research Site
  - Ghent, Belgium, 9000
    - Recruiting
    - Research Site
  - Leuven, Belgium, 3000
    - Recruiting
    - Research Site
  - Namur, Belgium, 5000
    - Recruiting
    - Research Site
  - Wilrijk, Belgium, 2610
    - Recruiting
    - Research Site
Brazil
- - Alfenas, Brazil, 37130-000
    - Recruiting
    - Research Site
  - Belo Horizonte, Brazil, 30130-100
    - Recruiting
    - Research Site
  - Blumenau, Brazil, 89010-340
    - Recruiting
    - Research Site
  - Brasília, Brazil, 71615-907
    - Recruiting
    - Research Site
  - Curitiba, Brazil, 80810-050
    - Recruiting
    - Research Site
  - Curitiba, Brazil, 80730-380
    - Recruiting
    - Research Site
  - Fortaleza, Brazil, 60430-230
    - Recruiting
    - Research Site
  - Fortaleza, Brazil, 60135-237
    - Recruiting
    - Research Site
  - Goiânia, Brazil, 74000-000
    - Recruiting
    - Research Site
  - Itajaí, Brazil, 88301-220
    - Recruiting
    - Research Site
  - João Pessoa, Brazil, 58013-140
    - Recruiting
    - Research Site
  - Natal, Brazil, 59075-740
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 90050-170
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 90035-001
    - Recruiting
    - Research Site
  - Porto Alegre, Brazil, 90610000
    - Recruiting
    - Research Site
  - Porto Velho, Brazil, 76834-899
    - Recruiting
    - Research Site
  - Pouso Alegre, Brazil, 37554-216
    - Recruiting
    - Research Site
  - Recife, Brazil, 50070-480
    - Recruiting
    - Research Site
  - Ribeirão Preto, Brazil, 14015-130
    - Recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 20560-120
    - Recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 22793-080
    - Recruiting
    - Research Site
  - Salvador, Brazil, 40170-110
    - Recruiting
    - Research Site
  - Santo André, Brazil, 09060-650
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 01246-000
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 01409-902
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 01327-001
    - Recruiting
    - Research Site
  - São Paulo, Brazil, 03102-006
    - Recruiting
    - Research Site
  - Taubaté, Brazil, 12030-200
    - Recruiting
    - Research Site
  - Teresina, Brazil, 64049-200
    - Recruiting
    - Research Site
  - Três Lagoas, Brazil, 79601-001
    - Recruiting
    - Research Site
  - Vitória, Brazil, 29043-260
    - Recruiting
    - Research Site
Bulgaria
- - Dobrich, Bulgaria, 9300
    - Recruiting
    - Research Site
  - Haskovo, Bulgaria, 6300
    - Recruiting
    - Research Site
  - Plovdiv, Bulgaria, 4004
    - Recruiting
    - Research Site
  - Plovdiv, Bulgaria, 4002
    - Recruiting
    - Research Site
  - Shumen, Bulgaria, 9700
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1407
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1330
    - Recruiting
    - Research Site
  - Sofia, Bulgaria, 1431
    - Withdrawn
    - Research Site
  - Sofia, Bulgaria, 1404
    - Terminated
    - Research Site
  - Varna, Bulgaria, 9010
    - Withdrawn
    - Research Site
  - Vratsa, Bulgaria, 3000
    - Terminated
    - Research Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Recruiting
    - Research Site
  - Edmonton, Alberta, Canada, t6G1Z2
    - Recruiting
    - Research Site
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - Recruiting
    - Research Site
  - North Vancouver, British Columbia, Canada, V7L 2L7
    - Active, not recruiting
    - Research Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Withdrawn
    - Research Site
- Ontario
  - Barrie, Ontario, Canada, L4M 6M2
    - Recruiting
    - Research Site
  - Greater Sudbury, Ontario, Canada, P3E 5J1
    - Recruiting
    - Research Site
  - Kingston, Ontario, Canada, K7L 2V7
    - Recruiting
    - Research Site
  - Sault Ste. Marie, Ontario, Canada, P6A 0A8
    - Withdrawn
    - Research Site
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Recruiting
    - Research Site
  - Windsor, Ontario, Canada, N8W 2X3
    - Withdrawn
    - Research Site
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - Recruiting
    - Research Site
  - Lévis, Quebec, Canada, G6V 3Z1
    - Recruiting
    - Research Site
  - Montreal, Quebec, Canada, H4A 3J1
    - Recruiting
    - Research Site
  - Montreal, Quebec, Canada, H2X 3E4
    - Recruiting
    - Research Site
  - Montreal, Quebec, Canada, H1T 2M4
    - Recruiting
    - Research Site
  - Québec, Quebec, Canada, G1S 4L8
    - Recruiting
    - Research Site
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Recruiting
    - Research Site
Chile
- - Concepción, Chile, 4070196
    - Recruiting
    - Research Site
  - La Serena, Chile, 1720430
    - Recruiting
    - Research Site
  - Port Montt, Chile, 5500243
    - Recruiting
    - Research Site
  - Providencia, Chile, 7510032
    - Withdrawn
    - Research Site
  - Santiago, Chile, 7620157
    - Recruiting
    - Research Site
  - Santiago, Chile, 8150215
    - Recruiting
    - Research Site
  - Santiago, Chile, 8330032
    - Recruiting
    - Research Site
  - Santiago, Chile, 8330336
    - Recruiting
    - Research Site
  - Temuco, Chile, 4810218
    - Recruiting
    - Research Site
  - Viña del Mar, Chile, 2520000
    - Recruiting
    - Research Site
China
- - Baoding, China, 071000
    - Recruiting
    - Research Site
  - Beijing, China, 100191
    - Recruiting
    - Research Site
  - Beijing, China, 100730
    - Recruiting
    - Research Site
  - Beijing, China, 100142
    - Recruiting
    - Research Site
  - Beijing, China, 100039
    - Recruiting
    - Research Site
  - Beijing, China, 100021
    - Recruiting
    - Research Site
  - Bengbu, China, 233004
    - Recruiting
    - Research Site
  - Binzhou, China, 256606
    - Recruiting
    - Research Site
  - Cangzhou, China, 061001
    - Recruiting
    - Research Site
  - Changchun, China, 130021
    - Recruiting
    - Research Site
  - Changsha, China, 410008
    - Recruiting
    - Research Site
  - Chengdu, China, 610072
    - Recruiting
    - Research Site
  - Chengdu, China, 610042
    - Recruiting
    - Research Site
  - Chifeng, China, 024000
    - Recruiting
    - Research Site
  - Dalian, China, 116011
    - Withdrawn
    - Research Site
  - Foshan, China, 528000
    - Recruiting
    - Research Site
  - Fuzhou, China, 350014
    - Recruiting
    - Research Site
  - Guangzhou, China, 510060
    - Recruiting
    - Research Site
  - Guangzhou, China, 510080
    - Withdrawn
    - Research Site
  - Guangzhou, China, 510168
    - Withdrawn
    - Research Site
  - Haikou, China, 570311
    - Recruiting
    - Research Site
  - Haikou, China, 570311
    - Withdrawn
    - Research Site
  - Hangzhou, China, 310009
    - Recruiting
    - Research Site
  - Hangzhou, China, 310022
    - Recruiting
    - Research Site
  - Hangzhou, China, 310000
    - Recruiting
    - Research Site
  - Hangzhou, China, 310016
    - Recruiting
    - Research Site
  - Harbin, China, 150081
    - Recruiting
    - Research Site
  - Hefei, China, 230601
    - Recruiting
    - Research Site
  - Hefei, China, 230001
    - Recruiting
    - Research Site
  - Hefei, China, 230022
    - Recruiting
    - Research Site
  - Hefei, China, 230012
    - Recruiting
    - Research Site
  - Hohhot, China, 010017
    - Recruiting
    - Research Site
  - Huizhou, China, 516001
    - Recruiting
    - Research Site
  - Jinzhou, China, 121001
    - Recruiting
    - Research Site
  - Lanzhou, China, 730050
    - Recruiting
    - Research Site
  - Linyi, China, 276000
    - Recruiting
    - Research Site
  - Liuzhou, China, 545006
    - Recruiting
    - Research Site
  - Liuzhou, China, 545005
    - Recruiting
    - Research Site
  - Nanchang, China, 330009
    - Recruiting
    - Research Site
  - Nanjing, China, 210029
    - Recruiting
    - Research Site
  - Nanjing, China, 210009
    - Withdrawn
    - Research Site
  - Nanning, China, 530021
    - Recruiting
    - Research Site
  - Nantong, China, 226001
    - Recruiting
    - Research Site
  - Neijiang, China, 641000
    - Recruiting
    - Research Site
  - Shandong, China, 250117
    - Recruiting
    - Research Site
  - Shangqiu, China, 476100
    - Recruiting
    - Research Site
  - Shantou, China, 515031
    - Recruiting
    - Research Site
  - Shaoguan Shi, China, 512025
    - Recruiting
    - Research Site
  - Shenyang, China, 110042
    - Recruiting
    - Research Site
  - Shenyang, China, 110001
    - Withdrawn
    - Research Site
  - Shenzhen, China, 518020
    - Recruiting
    - Research Site
  - Shenzhen, China, 518116
    - Withdrawn
    - Research Site
  - Shijiazhuang, China, 050011
    - Recruiting
    - Research Site
  - Suining Shi, China, 629000
    - Recruiting
    - Research Site
  - Suzhou, China, 215004
    - Recruiting
    - Research Site
  - Suzhou, China, 215006
    - Withdrawn
    - Research Site
  - Suzhou, China, 215600
    - Recruiting
    - Research Site
  - Taizhou, China, 317000
    - Recruiting
    - Research Site
  - Tianjin, China, 300060
    - Recruiting
    - Research Site
  - Weifang, China, 261000
    - Recruiting
    - Research Site
  - Wuhan, China, 430060
    - Recruiting
    - Research Site
  - Wuhan, China, 430079
    - Recruiting
    - Research Site
  - Wuhan, China, 430030
    - Withdrawn
    - Research Site
  - Xi'an, China, 710004
    - Recruiting
    - Research Site
  - Xiangfan, China, 441021
    - Recruiting
    - Research Site
  - Xinxiang, China, 453100
    - Recruiting
    - Research Site
  - Xuzhou, China, 221009
    - Recruiting
    - Research Site
  - Xuzhou, China, 221002
    - Recruiting
    - Research Site
  - Zunyi, China, 563100
    - Recruiting
    - Research Site
Colombia
- - Barranquilla, Colombia, 080020
    - Recruiting
    - Research Site
  - Bogotá, Colombia, 110221
    - Recruiting
    - Research Site
  - Cali, Colombia, 760042
    - Recruiting
    - Research Site
  - Medellín, Colombia, 050030
    - Recruiting
    - Research Site
  - Montería, Colombia, 23001
    - Recruiting
    - Research Site
  - Valledupar, Colombia, 200001
    - Recruiting
    - Research Site
Croatia
- - Osijek, Croatia, 31000
    - Recruiting
    - Research Site
  - Rijeka, Croatia, 51000
    - Not yet recruiting
    - Research Site
  - Split, Croatia, 21000
    - Recruiting
    - Research Site
  - Zadar, Croatia, 23000
    - Terminated
    - Research Site
  - Zagreb, Croatia, 10000
    - Recruiting
    - Research Site
Czechia
- - Brno, Czechia, 625 00
    - Recruiting
    - Research Site
  - Hořovice, Czechia, 26831
    - Withdrawn
    - Research Site
  - Liberec, Czechia, 46063
    - Recruiting
    - Research Site
  - Pardubice, Czechia, 532 03
    - Recruiting
    - Research Site
  - Prague, Czechia, 150 06
    - Recruiting
    - Research Site
Estonia
- - Tallinn, Estonia, 11619
    - Recruiting
    - Research Site
  - Tallinn, Estonia, 10138
    - Recruiting
    - Research Site
  - Tartu, Estonia, 50406
    - Recruiting
    - Research Site
France
- - Angers, France, 49100
    - Recruiting
    - Research Site
  - Bordeaux, France, 33076
    - Recruiting
    - Research Site
  - Caen, France, 14076
    - Recruiting
    - Research Site
  - Clermont-Ferrand, France, 63000
    - Recruiting
    - Research Site
  - Dijon, France, 21000
    - Recruiting
    - Research Site
  - Epagny Metz-Tessy, France, 74370
    - Recruiting
    - Research Site
  - Lille, France, 59000
    - Recruiting
    - Research Site
  - Lyon, France, 75004
    - Active, not recruiting
    - Research Site
  - Marseille, France, 13273
    - Recruiting
    - Research Site
  - Montpellier, France, 34298
    - Recruiting
    - Research Site
  - Nantes, France, 44277
    - Recruiting
    - Research Site
  - Nîmes, France, 30029
    - Recruiting
    - Research Site
  - Paris, France, 75005
    - Recruiting
    - Research Site
  - Pierre-Bénite, France, 69495
    - Recruiting
    - Research Site
  - Plerin SUR MER, France, 22190
    - Withdrawn
    - Research Site
  - Rennes, France, 35000
    - Recruiting
    - Research Site
  - Rouen, France, 76021
    - Recruiting
    - Research Site
  - Saint-Cloud, France, 92210
    - Recruiting
    - Research Site
  - Saint-Herblain, France, 44800
    - Recruiting
    - Research Site
  - Saint-Priest-en-Jarez, France, 42270
    - Recruiting
    - Research Site
  - Strasbourg, France, 67200
    - Recruiting
    - Research Site
  - Toulouse, France, 31059
    - Recruiting
    - Research Site
  - Vandœuvre-lès-Nancy, France, 54519
    - Recruiting
    - Research Site
  - Villejuif, France, 94805
    - Recruiting
    - Research Site
Georgia
- - Batumi, Georgia, 6000
    - Recruiting
    - Research Site
  - Tbilisi, Georgia, 0112
    - Recruiting
    - Research Site
  - Tbilisi, Georgia, 114
    - Recruiting
    - Research Site
  - Tbilisi, Georgia, 160
    - Withdrawn
    - Research Site
  - Tbilisi, Georgia, 0186
    - Withdrawn
    - Research Site
  - Tbilisi, Georgia, 0102
    - Withdrawn
    - Research Site
  - Tbilisi, Georgia, 0179
    - Withdrawn
    - Research Site
Germany
- - Aachen, Germany, 52074
    - Recruiting
    - Research Site
  - Berlin, Germany, 12559
    - Recruiting
    - Research Site
  - Cologne, Germany, 51067
    - Recruiting
    - Research Site
  - Darmstadt, Germany, 64283
    - Recruiting
    - Research Site
  - Deggendorf, Germany, 94469
    - Recruiting
    - Research Site
  - Dessau, Germany, 6847
    - Recruiting
    - Research Site
  - Dresden, Germany, 01127
    - Withdrawn
    - Research Site
  - Düsseldorf, Germany, 40235
    - Recruiting
    - Research Site
  - Essen, Germany, 45130
    - Recruiting
    - Research Site
  - Freudenstadt, Germany, 72250
    - Withdrawn
    - Research Site
  - Georgsmarienhütte, Germany, 49124
    - Recruiting
    - Research Site
  - Hamburg, Germany, 22457
    - Recruiting
    - Research Site
  - Hamburg, Germany, 20357
    - Recruiting
    - Research Site
  - Hamm, Germany, 59073
    - Withdrawn
    - Research Site
  - Hanau, Germany, 63450
    - Withdrawn
    - Research Site
  - Hanover, Germany, 30177
    - Recruiting
    - Research Site
  - Hanover, Germany, 30559
    - Recruiting
    - Research Site
  - Heidelberg, Germany, 69120
    - Recruiting
    - Research Site
  - Karlsruhe, Germany, 76135
    - Recruiting
    - Research Site
  - Koblenz, Germany, 56068
    - Recruiting
    - Research Site
  - Mainz, Germany, 55131
    - Recruiting
    - Research Site
  - Nürtingen, Germany, 72622
    - Withdrawn
    - Research Site
  - Offenburg, Germany, 77654
    - Recruiting
    - Research Site
  - Rostock, Germany, 18057
    - Recruiting
    - Research Site
  - Saarbrücken, Germany, 66113
    - Recruiting
    - Research Site
  - Schweinfurt, Germany, 97421
    - Recruiting
    - Research Site
  - Speyer, Germany, 67346
    - Withdrawn
    - Research Site
  - Torgau, Germany, 4860
    - Recruiting
    - Research Site
  - Wiesbaden, Germany, 65199
    - Recruiting
    - Research Site
  - Wiesbaden, Germany, 65189
    - Recruiting
    - Research Site
  - Witten, Germany, 58452
    - Recruiting
    - Research Site
  - Worms, Germany, 67550
    - Recruiting
    - Research Site
  - Wuppertal, Germany, 42283
    - Recruiting
    - Research Site
Greece
- - Athens, Greece, 11528
    - Recruiting
    - Research Site
  - Athens, Greece, 12462
    - Recruiting
    - Research Site
  - Athens, Greece, 11527, GR
    - Recruiting
    - Research Site
  - Athens, Greece, 115 22
    - Recruiting
    - Research Site
  - Athens, Greece, 11528
    - Withdrawn
    - Research Site
  - Heraklion, Greece, 71110
    - Recruiting
    - Research Site
  - Ioannina, Greece, 455 00
    - Recruiting
    - Research Site
  - Larissa, Greece, 41335, GR
    - Recruiting
    - Research Site
  - Marousi, Greece, 151 23
    - Recruiting
    - Research Site
  - Piraeus, Greece, 185 37
    - Recruiting
    - Research Site
  - Rio, Greece, 265 04
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 546 39
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 552 36
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 56403
    - Recruiting
    - Research Site
  - Thessaloniki, Greece, 54645
    - Withdrawn
    - Research Site
  - Thessaloniki, Greece, 570 01
    - Recruiting
    - Research Site
Hungary
- - Budapest, Hungary, 1122
    - Recruiting
    - Research Site
  - Budapest, Hungary, 1082
    - Recruiting
    - Research Site
  - Debrecen, Hungary, 4032
    - Active, not recruiting
    - Research Site
  - Gyula, Hungary, 5700
    - Recruiting
    - Research Site
  - Győr, Hungary, 9024
    - Withdrawn
    - Research Site
  - Kaposvár, Hungary, 7400
    - Recruiting
    - Research Site
  - Kecskemét, Hungary, 6000
    - Recruiting
    - Research Site
  - Miskolc, Hungary, 3526
    - Recruiting
    - Research Site
  - Nyíregyháza, Hungary, 4400
    - Recruiting
    - Research Site
  - Salgótarján, Hungary, 3100
    - Recruiting
    - Research Site
  - Szeged, Hungary, 6725
    - Recruiting
    - Research Site
  - Szekszárd, Hungary, 7100
    - Recruiting
    - Research Site
  - Zalaegerszeg, Hungary, 8900
    - Recruiting
    - Research Site
India
- - Ansārinagar, India, 110 029
    - Recruiting
    - Research Site
  - Bangalore, India, 560064
    - Recruiting
    - Research Site
  - Belgavi, India, 590010
    - Withdrawn
    - Research Site
  - Dehradun, India, 248016
    - Recruiting
    - Research Site
  - Delhi, India, 110088
    - Recruiting
    - Research Site
  - Dhanvantari Nagar, India, 605006
    - Withdrawn
    - Research Site
  - Gurgaon, India, 122001
    - Withdrawn
    - Research Site
  - Hyderabad, India, 500082
    - Withdrawn
    - Research Site
  - Jaipur, India, 302022
    - Withdrawn
    - Research Site
  - Kanpur, India, 208005
    - Withdrawn
    - Research Site
  - Kolkata, India, 700160
    - Recruiting
    - Research Site
  - Kolkata, India, 700099
    - Withdrawn
    - Research Site
  - Kozhikode, India, 673 601
    - Recruiting
    - Research Site
  - Mumbai, India, 400012
    - Withdrawn
    - Research Site
  - Mumbai, India, 400612
    - Recruiting
    - Research Site
  - Mysuru, India, 570017
    - Recruiting
    - Research Site
  - Nagpur, India, 440001
    - Recruiting
    - Research Site
  - Nashik, India, 422002
    - Recruiting
    - Research Site
  - Nashik, India, 422 009
    - Recruiting
    - Research Site
  - New Delhi, India, 110029
    - Recruiting
    - Research Site
  - New Delhi, India, 110 085
    - Recruiting
    - Research Site
  - New Delhi, India, 110075
    - Recruiting
    - Research Site
  - Surat, India, 395002
    - Recruiting
    - Research Site
Ireland
- - Cork, Ireland, T12 DV56
    - Recruiting
    - Research Site
  - Dublin, Ireland, 7
    - Recruiting
    - Research Site
  - Dublin, Ireland, D09V2N0
    - Recruiting
    - Research Site
  - Dublin, Ireland, DO4YN63
    - Recruiting
    - Research Site
  - Dublin, Ireland, 7
    - Active, not recruiting
    - Research Site
  - Galway, Ireland, H91 YR71
    - Recruiting
    - Research Site
  - Waterford, Ireland, X91 ER8E
    - Recruiting
    - Research Site
Israel
- - Afula, Israel, 18101
    - Recruiting
    - Research Site
  - Ashdod, Israel, 7747629
    - Withdrawn
    - Research Site
  - Beersheba, Israel, 84101
    - Withdrawn
    - Research Site
  - Haifa, Israel, 31096
    - Recruiting
    - Research Site
  - Jerusalem, Israel, 91120
    - Recruiting
    - Research Site
  - Jerusalem, Israel, 9103102
    - Withdrawn
    - Research Site
  - Kfar Saba, Israel, 49281
    - Recruiting
    - Research Site
  - Nahariya, Israel, 22100
    - Recruiting
    - Research Site
  - Ramat Gan, Israel, 5262000
    - Recruiting
    - Research Site
Italy
- - Bergamo, Italy, 24127
    - Recruiting
    - Research Site
  - Bologna, Italy, 40138
    - Recruiting
    - Research Site
  - Brindisi, Italy, 72100
    - Withdrawn
    - Research Site
  - Florence, Italy, 50134
    - Recruiting
    - Research Site
  - Genoa, Italy, 16132
    - Recruiting
    - Research Site
  - Meldola, Italy, 47014
    - Recruiting
    - Research Site
  - Milan, Italy, 20132
    - Recruiting
    - Research Site
  - Milan, Italy, 20141
    - Recruiting
    - Research Site
  - Misterbianco, Italy, 95045
    - Recruiting
    - Research Site
  - Modena, Italy, 41124
    - Withdrawn
    - Research Site
  - Monza, Italy, 20900
    - Recruiting
    - Research Site
  - Naples, Italy, 80131
    - Recruiting
    - Research Site
  - Novara, Italy, 28100
    - Recruiting
    - Research Site
  - Padova, Italy, 35128
    - Recruiting
    - Research Site
  - Roma, Italy, 00168
    - Recruiting
    - Research Site
  - Roma, Italy, 00161
    - Recruiting
    - Research Site
  - Rozzano, Italy, 20089
    - Recruiting
    - Research Site
  - Torino, Italy, 10126
    - Recruiting
    - Research Site
  - Trento, Italy, 38100
    - Recruiting
    - Research Site
Japan
- - Bunkyō City, Japan, 113-8431
    - Recruiting
    - Research Site
  - Chiba, Japan, 260-8717
    - Recruiting
    - Research Site
  - Chūōku, Japan, 104-8560
    - Recruiting
    - Research Site
  - Fukuoka, Japan, 811-1395
    - Recruiting
    - Research Site
  - Fukushima, Japan, 960-1295
    - Recruiting
    - Research Site
  - Hirakata-shi, Japan, 573-1191
    - Recruiting
    - Research Site
  - Hiroshima, Japan, 730-8518
    - Recruiting
    - Research Site
  - Iruma-Gun, Japan, 350-0495
    - Recruiting
    - Research Site
  - Isehara-shi, Japan, 259-1193
    - Recruiting
    - Research Site
  - Kagoshima, Japan, 892-0833
    - Recruiting
    - Research Site
  - Kamogawa-shi, Japan, 296-0041
    - Recruiting
    - Research Site
  - Kashiwa, Japan, 277-8577
    - Withdrawn
    - Research Site
  - Kumamoto, Japan, 860-8556
    - Recruiting
    - Research Site
  - Kurume-shi, Japan, 830-0013
    - Recruiting
    - Research Site
  - Kyoto, Japan, 606-8507
    - Recruiting
    - Research Site
  - Kōtoku, Japan, 135-8550
    - Recruiting
    - Research Site
  - Matsuyama, Japan, 791-0280
    - Recruiting
    - Research Site
  - Nagoya, Japan, 464-8681
    - Recruiting
    - Research Site
  - Nagoya, Japan, 467-0001
    - Recruiting
    - Research Site
  - Nagoya, Japan, 466-8550
    - Recruiting
    - Research Site
  - Niigata, Japan, 951-8566
    - Recruiting
    - Research Site
  - Osaka, Japan, 541-8567
    - Recruiting
    - Research Site
  - Ota-shi, Japan, 373-8550
    - Recruiting
    - Research Site
  - Sapporo, Japan, 060-8638
    - Recruiting
    - Research Site
  - Sapporo, Japan, 003-0804
    - Recruiting
    - Research Site
  - Sendai, Japan
    - Recruiting
    - Research Site
  - Shinagawa-ku, Japan, 142-8666
    - Recruiting
    - Research Site
  - Suita-shi, Japan, 565-0871
    - Recruiting
    - Research Site
  - Sunto-gun, Japan, 411-8777
    - Recruiting
    - Research Site
  - Takasaki-shi, Japan, 370-0829
    - Recruiting
    - Research Site
  - Tsu, Japan, 514-8507
    - Recruiting
    - Research Site
  - Utsunomiya, Japan, 320-0834
    - Recruiting
    - Research Site
  - Yokohama, Japan, 241-8515
    - Recruiting
    - Research Site
  - Yokohama, Japan, 222-0036
    - Recruiting
    - Research Site
Malaysia
- - Johor Bahru, Malaysia, 81100
    - Recruiting
    - Research Site
  - Kota Bharu, Malaysia, 16150
    - Withdrawn
    - Research Site
  - Kuala Lumpur, Malaysia, 50586
    - Recruiting
    - Research Site
  - Kuala Lumpur, Malaysia, 50603
    - Withdrawn
    - Research Site
  - Kuching, Malaysia, 93200
    - Recruiting
    - Research Site
  - Malacca, Malaysia, 75000
    - Withdrawn
    - Research Site
  - Pulau Pinang, Malaysia, 10450
    - Recruiting
    - Research Site
Mexico
- - Alc. Cuauhtémoc, Mexico, 06700
    - Recruiting
    - Research Site
  - Alc. Cuauhtémoc, Mexico, 06100
    - Recruiting
    - Research Site
  - Cancún, Mexico, 77500
    - Withdrawn
    - Research Site
  - Colonia Lindavista, Mexico, 7300
    - Withdrawn
    - Research Site
  - Estado de México, Mexico, 50090
    - Withdrawn
    - Research Site
  - Monterrey, Mexico, 64460
    - Withdrawn
    - Research Site
  - Monterrey, Mexico, 66220
    - Withdrawn
    - Research Site
  - Mérida, Mexico, 97300
    - Recruiting
    - Research Site
  - Mérida, Mexico, 97300
    - Withdrawn
    - Research Site
  - México, Mexico, 14080
    - Withdrawn
    - Research Site
  - San Luis Potosí City, Mexico, 78209
    - Recruiting
    - Research Site
  - Tuxtla Gutiérrez, Mexico, 29000
    - Not yet recruiting
    - Research Site
  - Veracruz, Mexico, 91851
    - Recruiting
    - Research Site
New Zealand
- - Auckland, New Zealand, 1023
    - Recruiting
    - Research Site
  - Hamilton, New Zealand, 3204
    - Recruiting
    - Research Site
  - Palmerston North, New Zealand, 4414
    - Recruiting
    - Research Site
Peru
- - Arequipa, Peru, AREQUIPA01
    - Recruiting
    - Research Site
  - La Libertad, Peru, 13013
    - Withdrawn
    - Research Site
  - Lima, Peru, LIMA 29
    - Recruiting
    - Research Site
  - Lima, Peru, Lima 34
    - Recruiting
    - Research Site
  - Lima, Peru, 15023
    - Recruiting
    - Research Site
  - Lima, Peru, LIMA 01
    - Withdrawn
    - Research Site
  - Lima, Peru, 15076
    - Recruiting
    - Research Site
  - Lima, Peru, 15073
    - Recruiting
    - Research Site
  - Lima, Peru, Lima 13
    - Withdrawn
    - Research Site
  - San Isidro, Peru
    - Recruiting
    - Research Site
  - Trujillo, Peru, 044
    - Recruiting
    - Research Site
Philippines
- - Bacolod, Philippines, 6100
    - Recruiting
    - Research Site
  - Cebu City, Philippines, 6000
    - Recruiting
    - Research Site
  - Iloilo City, Philippines, 5000
    - Withdrawn
    - Research Site
  - Manila, Philippines, 1000
    - Withdrawn
    - Research Site
  - Quezon, Philippines, 1102
    - Recruiting
    - Research Site
Poland
- - Bialystok, Poland, 15-027
    - Active, not recruiting
    - Research Site
  - Biała Podlaska, Poland, 21-500
    - Active, not recruiting
    - Research Site
  - Bydgoszcz, Poland, 85-796
    - Active, not recruiting
    - Research Site
  - Gdansk, Poland, 80-952
    - Active, not recruiting
    - Research Site
  - Gdynia, Poland, 81-519
    - Active, not recruiting
    - Research Site
  - Grudziądz, Poland, 86-300
    - Withdrawn
    - Research Site
  - Koszalin, Poland, 75-581
    - Active, not recruiting
    - Research Site
  - Krakow, Poland, 31-501
    - Active, not recruiting
    - Research Site
  - Lodz, Poland, 90-302
    - Active, not recruiting
    - Research Site
  - Lublin, Poland, 20-090
    - Withdrawn
    - Research Site
  - Lublin, Poland, 20-718
    - Withdrawn
    - Research Site
  - Opole, Poland, 45-061
    - Active, not recruiting
    - Research Site
  - Poznan, Poland, 61-485
    - Withdrawn
    - Research Site
  - Racibórz, Poland, 47-400
    - Withdrawn
    - Research Site
  - Rzeszów, Poland, 35-021
    - Active, not recruiting
    - Research Site
  - Rzeszów, Poland, 35-055
    - Active, not recruiting
    - Research Site
  - Szczecin, Poland, 71-730
    - Withdrawn
    - Research Site
  - Tomaszów Mazowiecki, Poland, 97-200
    - Withdrawn
    - Research Site
  - Warsaw, Poland, 02-781
    - Active, not recruiting
    - Research Site
  - Wroclaw, Poland, 53-413
    - Active, not recruiting
    - Research Site
Portugal
- - Amadora, Portugal, 2720-276
    - Recruiting
    - Research Site
  - Braga, Portugal, 4710-243
    - Recruiting
    - Research Site
  - Lisbon, Portugal, 1649-035
    - Recruiting
    - Research Site
  - Lisbon, Portugal, 1998-018
    - Recruiting
    - Research Site
  - Matosinhos Municipality, Portugal, 4454-509
    - Withdrawn
    - Research Site
  - Porto, Portugal, 4200-072
    - Recruiting
    - Research Site
  - Porto, Portugal, 4100-180
    - Not yet recruiting
    - Research Site
  - Viana do Castelo, Portugal, 4904-858
    - Withdrawn
    - Research Site
  - Vila Nova de Gaia, Portugal, 4434-502
    - Recruiting
    - Research Site
  - Vila Real, Portugal, 5000-508
    - Not yet recruiting
    - Research Site
Puerto Rico
- - Rio Piedras, Puerto Rico, 00935
    - Recruiting
    - Research Site
Romania
- - Bucharest, Romania, 013812
    - Recruiting
    - Research Site
  - Bucharest, Romania, 011171
    - Recruiting
    - Research Site
  - Cluj-Napoca, Romania, 400015
    - Recruiting
    - Research Site
  - Cluj-Napoca, Romania, 400641
    - Withdrawn
    - Research Site
  - Craiova, Romania, 200094
    - Recruiting
    - Research Site
  - Craiova, Romania, 200385
    - Recruiting
    - Research Site
  - Craiova, Romania, 200542
    - Recruiting
    - Research Site
  - Floreşti, Romania, 407280
    - Recruiting
    - Research Site
  - Iași, Romania, 700106
    - Withdrawn
    - Research Site
  - Oradea, Romania, 410469
    - Withdrawn
    - Research Site
  - Otopeni, Romania, 075100
    - Recruiting
    - Research Site
  - Ovidiu, Romania, 905900
    - Recruiting
    - Research Site
  - Piteşti, Romania, 110283
    - Recruiting
    - Research Site
  - Sibiu, Romania, 550245
    - Withdrawn
    - Research Site
  - Timișoara, Romania, 300166
    - Withdrawn
    - Research Site
  - Timișoara, Romania, 300239
    - Recruiting
    - Research Site
Saudi Arabia
- - Riyadh, Saudi Arabia, 12713
    - Withdrawn
    - Research Site
  - Riyadh, Saudi Arabia, 12713
    - Recruiting
    - Research Site
  - Riyadh/MENA, Saudi Arabia, 11426
    - Recruiting
    - Research Site
Serbia
- - Belgrade, Serbia, 11000
    - Recruiting
    - Research Site
  - Belgrade, Serbia, 11080
    - Recruiting
    - Research Site
  - Belgrade, Serbia, 11010
    - Withdrawn
    - Research Site
  - Kragujevac, Serbia, 34000
    - Recruiting
    - Research Site
  - Niš, Serbia, 18000
    - Recruiting
    - Research Site
  - Novi Sad, Serbia, 21000
    - Recruiting
    - Research Site
  - Valjevo, Serbia, 14000
    - Recruiting
    - Research Site
  - Zrenjanin, Serbia, 23000
    - Recruiting
    - Research Site
South Africa
- - Bloemfontein, South Africa, 9301
    - Withdrawn
    - Research Site
  - Cape Town, South Africa, 7925
    - Recruiting
    - Research Site
  - George, South Africa, 6529
    - Recruiting
    - Research Site
  - Johannesburg, South Africa, 2196
    - Recruiting
    - Research Site
  - Johannesburg, South Africa, 2193
    - Recruiting
    - Research Site
  - Pietermaritzburg, South Africa, 3245
    - Recruiting
    - Research Site
  - Port Elizabeth, South Africa, 6045
    - Recruiting
    - Research Site
  - Pretoria, South Africa, 31
    - Recruiting
    - Research Site
  - eManzimtoti, South Africa, 4126
    - Withdrawn
    - Research Site
South Korea
- - Cheonan-si, South Korea, 31151
    - Recruiting
    - Research Site
  - Daegu, South Korea, 41404
    - Active, not recruiting
    - Research Site
  - Goyang-si, South Korea, 10408
    - Active, not recruiting
    - Research Site
  - Seongnam-si, South Korea, 13620
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 06351
    - Recruiting
    - Research Site
  - Seoul, South Korea, 06591
    - Recruiting
    - Research Site
  - Seoul, South Korea, 03080
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 03722
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 06273
    - Recruiting
    - Research Site
  - Seoul, South Korea, 02841
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 5505
    - Active, not recruiting
    - Research Site
Spain
- - A Coruña, Spain, 15006
    - Recruiting
    - Research Site
  - A Coruña, Spain, 15009
    - Recruiting
    - Research Site
  - Albacete, Spain, 02006
    - Recruiting
    - Research Site
  - Alicante, Spain, 03010
    - Recruiting
    - Research Site
  - Badalona, Spain, 08916
    - Recruiting
    - Research Site
  - Barakaldo, Spain, 48903
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08041
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08035
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08036
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08003
    - Recruiting
    - Research Site
  - Burgos, Spain, 09006
    - Recruiting
    - Research Site
  - Castellon, Spain, 12002
    - Active, not recruiting
    - Research Site
  - Cáceres, Spain, 10003
    - Recruiting
    - Research Site
  - Córdoba, Spain, 14004
    - Recruiting
    - Research Site
  - Donostia / San Sebastian, Spain, 20014
    - Recruiting
    - Research Site
  - El Palmar, Spain, 30120
    - Recruiting
    - Research Site
  - Elche(Alicante), Spain, 03202
    - Recruiting
    - Research Site
  - Fuenlabrada, Spain, 28942
    - Recruiting
    - Research Site
  - Girona, Spain, 17007
    - Recruiting
    - Research Site
  - Granada, Spain, 18016
    - Recruiting
    - Research Site
  - Granada, Spain, 18012
    - Recruiting
    - Research Site
  - Jerez de la Frontera, Spain, 11407
    - Recruiting
    - Research Site
  - La Laguna (Tenerife), Spain, 38320
    - Recruiting
    - Research Site
  - León, Spain, 24008
    - Recruiting
    - Research Site
  - Lleida, Spain, 25198
    - Recruiting
    - Research Site
  - Madrid, Spain, 28007
    - Recruiting
    - Research Site
  - Madrid, Spain, 28034
    - Recruiting
    - Research Site
  - Madrid, Spain, 28040
    - Recruiting
    - Research Site
  - Madrid, Spain, 28041
    - Recruiting
    - Research Site
  - Madrid, Spain, 28033
    - Recruiting
    - Research Site
  - Madrid, Spain, 28050
    - Recruiting
    - Research Site
  - Madrid, Spain, 28009
    - Recruiting
    - Research Site
  - Manresa, Spain, 08243
    - Recruiting
    - Research Site
  - Murcia, Spain, 30008
    - Recruiting
    - Research Site
  - Málaga, Spain, 29010
    - Recruiting
    - Research Site
  - Málaga, Spain, 29016
    - Recruiting
    - Research Site
  - Palma de Mallorca, Spain, 07120
    - Recruiting
    - Research Site
  - Reus, Spain, 43204
    - Recruiting
    - Research Site
  - Sabadell, Spain, 08208
    - Recruiting
    - Research Site
  - Salamanca, Spain, 37007
    - Recruiting
    - Research Site
  - Sant Joan Despí, Spain, 08970
    - Recruiting
    - Research Site
  - Seville, Spain, 41009
    - Recruiting
    - Research Site
  - Seville, Spain, 41014
    - Recruiting
    - Research Site
  - Seville, Spain, 41015
    - Recruiting
    - Research Site
  - Toledo, Spain, 45007
    - Recruiting
    - Research Site
  - Valencia, Spain, 46010
    - Recruiting
    - Research Site
  - Valencia, Spain, 46015
    - Recruiting
    - Research Site
  - Valencia, Spain, 46009
    - Recruiting
    - Research Site
  - Vigo, Spain, 36312
    - Recruiting
    - Research Site
  - Zaragoza, Spain, 50009
    - Recruiting
    - Research Site
Switzerland
- - Baden, Switzerland, CH-5405
    - Recruiting
    - Research Site
  - Basel, Switzerland, 4031
    - Recruiting
    - Research Site
  - Bellinzona, Switzerland, 6500
    - Recruiting
    - Research Site
  - Chur, Switzerland, 7000
    - Recruiting
    - Research Site
  - Frauenfeld, Switzerland, 8501
    - Recruiting
    - Research Site
  - La Chaux-de-Fonds, Switzerland, 2300
    - Recruiting
    - Research Site
  - Lausanne, Switzerland, 1011
    - Recruiting
    - Research Site
  - Lucerne, Switzerland, 6000
    - Recruiting
    - Research Site
  - Lucerne, Switzerland, 6006
    - Recruiting
    - Research Site
  - Sankt Gallen, Switzerland, 9016
    - Recruiting
    - Research Site
  - Winterthur, Switzerland, 8401
    - Recruiting
    - Research Site
  - Zurich, Switzerland, 8008
    - Active, not recruiting
    - Research Site
Taiwan
- - Hsinchu, Taiwan, 300
    - Recruiting
    - Research Site
  - Kaohsiung City, Taiwan, 833589
    - Recruiting
    - Research Site
  - New Taipei City, Taiwan, 23561
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 40705
    - Recruiting
    - Research Site
  - Taichung, Taiwan, 404
    - Withdrawn
    - Research Site
  - Tainan, Taiwan, 70403
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 10048
    - Recruiting
    - Research Site
  - Taipei, Taiwan, 11259
    - Recruiting
    - Research Site
  - Yongkang District, Taiwan, 71004
    - Recruiting
    - Research Site
Thailand
- - Bangkok, Thailand, 10210
    - Active, not recruiting
    - Research Site
  - Bangkok, Thailand, 10330
    - Active, not recruiting
    - Research Site
  - Bangkok, Thailand, 10400
    - Active, not recruiting
    - Research Site
  - Bangkok, Thailand, 10700
    - Active, not recruiting
    - Research Site
  - Hat Yai, Thailand, 90110
    - Active, not recruiting
    - Research Site
  - Khon Kaen, Thailand, 40002
    - Active, not recruiting
    - Research Site
Turkey (Türkiye)
- - Ankara, Turkey (Türkiye), 06200
    - Recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06010
    - Recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06530
    - Recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06250
    - Withdrawn
    - Research Site
  - Antalya, Turkey (Türkiye), 07100
    - Recruiting
    - Research Site
  - Bursa, Turkey (Türkiye), 16059
    - Recruiting
    - Research Site
  - Cordaleo, Turkey (Türkiye), 35575
    - Withdrawn
    - Research Site
  - Edirne, Turkey (Türkiye), 22030
    - Withdrawn
    - Research Site
  - Istanbul, Turkey (Türkiye), 34010
    - Withdrawn
    - Research Site
  - Istanbul, Turkey (Türkiye), 34093
    - Recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34722
    - Withdrawn
    - Research Site
  - Istanbul, Turkey (Türkiye), 34180
    - Recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34457
    - Recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34899
    - Withdrawn
    - Research Site
  - Malatya, Turkey (Türkiye), 44280
    - Withdrawn
    - Research Site
  - Samsun, Turkey (Türkiye), 55200
    - Recruiting
    - Research Site
  - Çankaya, Turkey (Türkiye), 06680
    - Withdrawn
    - Research Site
  - Çiğli, Turkey (Türkiye), 35620
    - Recruiting
    - Research Site
United Arab Emirates
- - Abu Dhabi, United Arab Emirates, 11241
    - Recruiting
    - Research Site
  - Al Ain City, United Arab Emirates, 15258
    - Recruiting
    - Research Site
  - Dubai, United Arab Emirates, 505004
    - Recruiting
    - Research Site
  - Dubai, United Arab Emirates, 0000
    - Recruiting
    - Research Site
United Kingdom
- - Aberdeen, United Kingdom, AB25 2ZN
    - Recruiting
    - Research Site
  - Bath, United Kingdom, BA1 3NG
    - Withdrawn
    - Research Site
  - Brighton, United Kingdom, BN2 5BD
    - Withdrawn
    - Research Site
  - Burton-on-Trent, United Kingdom, DE13 0RB
    - Recruiting
    - Research Site
  - Cambridge, United Kingdom, CB2 2QQ
    - Recruiting
    - Research Site
  - Derby, United Kingdom, DE22 3NE
    - Recruiting
    - Research Site
  - Guildford, United Kingdom, GU27XX
    - Recruiting
    - Research Site
  - Ipswich, United Kingdom, IP4 5PD
    - Recruiting
    - Research Site
  - Lancaster, United Kingdom, LA1 4RP
    - Recruiting
    - Research Site
  - Leeds, United Kingdom, LS9 7TF
    - Recruiting
    - Research Site
  - Leicester, United Kingdom, LE1 5WW
    - Recruiting
    - Research Site
  - Liverpool, United Kingdom, L7 8YA
    - Withdrawn
    - Research Site
  - London, United Kingdom, SE1 9RT
    - Recruiting
    - Research Site
  - London, United Kingdom, NW3 2QG
    - Recruiting
    - Research Site
  - London, United Kingdom, SW2 6JJ
    - Recruiting
    - Research Site
  - London, United Kingdom, EC1M 6BQ
    - Active, not recruiting
    - Research Site
  - Manchester, United Kingdom, M20 4BX
    - Recruiting
    - Research Site
  - Northampton, United Kingdom, NN1 5BD
    - Recruiting
    - Research Site
  - Oxford, United Kingdom, OX3 7LE
    - Withdrawn
    - Research Site
  - Reading, United Kingdom, RG1 5AN
    - Withdrawn
    - Research Site
  - Shrewsbury, United Kingdom, SY3 8XQ
    - Recruiting
    - Research Site
  - Stockton, United Kingdom, TS19 8PE
    - Withdrawn
    - Research Site
  - Sutton, United Kingdom, SM2 5PT
    - Recruiting
    - Research Site
  - Sutton in Ashfield, United Kingdom, NG17 4JL
    - Recruiting
    - Research Site
  - Taunton, United Kingdom, TA1 5DA
    - Recruiting
    - Research Site
  - Warwick, United Kingdom, CV34 5BW
    - Withdrawn
    - Research Site
  - Whitchurch, United Kingdom, CF14 2TL
    - Recruiting
    - Research Site
United States
- Alabama
  - Dothan, Alabama, United States, 36303
    - Recruiting
    - Research Site
- Arizona
  - Phoenix, Arizona, United States, 85054
    - Recruiting
    - Research Site
  - Tucson, Arizona, United States, 85745
    - Recruiting
    - Research Site
- Arkansas
  - Fayetteville, Arkansas, United States, 72703
    - Recruiting
    - Research Site
- California
  - Duarte, California, United States, 91010
    - Recruiting
    - Research Site
  - Fountain Valley, California, United States, 92708
    - Recruiting
    - Research Site
  - Greenbrae, California, United States, 94904
    - Withdrawn
    - Research Site
  - Irvine, California, United States, 92618
    - Recruiting
    - Research Site
  - La Jolla, California, United States, 92093
    - Recruiting
    - Research Site
  - Los Angeles, California, United States, 90017
    - Recruiting
    - Research Site
  - Monterey, California, United States, 93940
    - Withdrawn
    - Research Site
  - Walnut Creek, California, United States, 94598
    - Recruiting
    - Research Site
  - West Hollywood, California, United States, 90048
    - Recruiting
    - Research Site
- Colorado
  - Aurora, Colorado, United States, 80045
    - Active, not recruiting
    - Research Site
  - Littleton, Colorado, United States, 80120
    - Recruiting
    - Research Site
  - Littleton, Colorado, United States, 80129
    - Recruiting
    - Research Site
- Connecticut
  - New Haven, Connecticut, United States, 06510
    - Recruiting
    - Research Site
- Delaware
  - Newark, Delaware, United States, 19713
    - Recruiting
    - Research Site
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20016
    - Withdrawn
    - Research Site
- Florida
  - Clearwater, Florida, United States, 33756
    - Recruiting
    - Research Site
  - Fort Myers, Florida, United States, 33901
    - Recruiting
    - Research Site
  - Gainesville, Florida, United States, 32610
    - Recruiting
    - Research Site
  - Jacksonville, Florida, United States, 32224
    - Recruiting
    - Research Site
  - Orlando, Florida, United States, 32806
    - Withdrawn
    - Research Site
  - Pembroke Pines, Florida, United States, 33028
    - Recruiting
    - Research Site
  - Plantation, Florida, United States, 33324
    - Recruiting
    - Research Site
  - Plantation, Florida, United States, 33322
    - Recruiting
    - Research Site
  - St. Petersburg, Florida, United States, 33709
    - Recruiting
    - Research Site
  - St. Petersburg, Florida, United States, 33705
    - Active, not recruiting
    - Research Site
  - Tallahassee, Florida, United States, 32308
    - Terminated
    - Research Site
  - West Palm Beach, Florida, United States, 33401
    - Recruiting
    - Research Site
- Georgia
  - Atlanta, Georgia, United States, 30318
    - Recruiting
    - Research Site
  - Atlanta, Georgia, United States, 30322
    - Withdrawn
    - Research Site
  - Columbus, Georgia, United States, 31904
    - Withdrawn
    - Research Site
  - Marietta, Georgia, United States, 30060
    - Recruiting
    - Research Site
  - Savannah, Georgia, United States, 31404
    - Withdrawn
    - Research Site
  - Thomasville, Georgia, United States, 31792
    - Recruiting
    - Research Site
- Illinois
  - Chicago, Illinois, United States, 60637
    - Recruiting
    - Research Site
  - Elmhurst, Illinois, United States, 60126
    - Recruiting
    - Research Site
  - Naperville, Illinois, United States, 60540
    - Recruiting
    - Research Site
  - Park Ridge, Illinois, United States, 60068
    - Withdrawn
    - Research Site
  - Plainfield, Illinois, United States, 60585
    - Withdrawn
    - Research Site
  - Urbana, Illinois, United States, 61801
    - Recruiting
    - Research Site
- Indiana
  - Fort Wayne, Indiana, United States, 46804
    - Recruiting
    - Research Site
- Iowa
  - Des Moines, Iowa, United States, 50309
    - Recruiting
    - Research Site
- Kansas
  - Fairway, Kansas, United States, 66205
    - Withdrawn
    - Research Site
- Kentucky
  - Louisville, Kentucky, United States, 40202
    - Recruiting
    - Research Site
- Louisiana
  - New Orleans, Louisiana, United States, 70121
    - Recruiting
    - Research Site
- Maine
  - Scarborough, Maine, United States, 04074
    - Recruiting
    - Research Site
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Recruiting
    - Research Site
  - Baltimore, Maryland, United States, 21201
    - Withdrawn
    - Research Site
  - Baltimore, Maryland, United States, 21287
    - Withdrawn
    - Research Site
  - Bethesda, Maryland, United States, 20817
    - Recruiting
    - Research Site
  - Lutherville, Maryland, United States, 21093
    - Withdrawn
    - Research Site
  - Towson, Maryland, United States, 21204
    - Recruiting
    - Research Site
- Massachusetts
  - Boston, Massachusetts, United States, 02111
    - Recruiting
    - Research Site
  - Boston, Massachusetts, United States, 02115
    - Recruiting
    - Research Site
  - Hyannis, Massachusetts, United States, 02601
    - Withdrawn
    - Research Site
  - Worcester, Massachusetts, United States, 01655
    - Withdrawn
    - Research Site
- Michigan
  - Detroit, Michigan, United States, 48202
    - Recruiting
    - Research Site
  - Flint, Michigan, United States, 48503
    - Withdrawn
    - Research Site
  - Ypsilanti, Michigan, United States, 48197
    - Recruiting
    - Research Site
- Minnesota
  - Minneapolis, Minnesota, United States, 55416
    - Recruiting
    - Research Site
  - Rochester, Minnesota, United States, 55905
    - Recruiting
    - Research Site
- Missouri
  - Kansas City, Missouri, United States, 64111
    - Recruiting
    - Research Site
  - St Louis, Missouri, United States, 63110
    - Recruiting
    - Research Site
  - St Louis, Missouri, United States, 63131
    - Recruiting
    - Research Site
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Recruiting
    - Research Site
  - Omaha, Nebraska, United States, 68198
    - Withdrawn
    - Research Site
  - Omaha, Nebraska, United States, 68124
    - Recruiting
    - Research Site
- New Hampshire
  - Hooksett, New Hampshire, United States, 03106
    - Recruiting
    - Research Site
  - Lebanon, New Hampshire, United States, 03756
    - Withdrawn
    - Research Site
  - Manchester, New Hampshire, United States, 03103
    - Recruiting
    - Research Site
- New Jersey
  - New Brunswick, New Jersey, United States, 08901
    - Recruiting
    - Research Site
- New Mexico
  - Albuquerque, New Mexico, United States, 87109
    - Recruiting
    - Research Site
  - Farmington, New Mexico, United States, 87401
    - Recruiting
    - Research Site
- New York
  - Bay Shore, New York, United States, 11706
    - Recruiting
    - Research Site
  - East Syracuse, New York, United States, 13057
    - Recruiting
    - Research Site
  - Greenlawn, New York, United States, 11740
    - Recruiting
    - Research Site
  - New Hyde Park, New York, United States, 11042
    - Recruiting
    - Research Site
  - New York, New York, United States, 10065
    - Withdrawn
    - Research Site
  - New York, New York, United States, 10065
    - Recruiting
    - Research Site
  - New York, New York, United States, 10029
    - Recruiting
    - Research Site
  - Stony Brook, New York, United States, 11794
    - Recruiting
    - Research Site
  - White Plains, New York, United States, 10601
    - Recruiting
    - Research Site
- North Carolina
  - Charlotte, North Carolina, United States, 28204
    - Recruiting
    - Research Site
  - Durham, North Carolina, United States, 27710
    - Withdrawn
    - Research Site
  - Greensboro, North Carolina, United States, 27403
    - Withdrawn
    - Research Site
  - Greenville, North Carolina, United States, 27834
    - Withdrawn
    - Research Site
  - Pinehurst, North Carolina, United States, 28374
    - Recruiting
    - Research Site
  - Raleigh, North Carolina, United States, 27607
    - Recruiting
    - Research Site
  - Winston-Salem, North Carolina, United States, 27103
    - Recruiting
    - Research Site
- Ohio
  - Blue Ash, Ohio, United States, 45242
    - Withdrawn
    - Research Site
  - Cincinnati, Ohio, United States, 45255
    - Recruiting
    - Research Site
  - Cleveland, Ohio, United States, 44106
    - Recruiting
    - Research Site
  - Columbus, Ohio, United States, 43212
    - Recruiting
    - Research Site
  - Toledo, Ohio, United States, 43623
    - Withdrawn
    - Research Site
  - Youngstown, Ohio, United States, 44504
    - Withdrawn
    - Research Site
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73104
    - Withdrawn
    - Research Site
- Oregon
  - Portland, Oregon, United States, 97213
    - Recruiting
    - Research Site
  - Portland, Oregon, United States, 97210
    - Recruiting
    - Research Site
  - Portland, Oregon, United States, 97225
    - Active, not recruiting
    - Research Site
- Pennsylvania
  - Gettysburg, Pennsylvania, United States, 17325
    - Recruiting
    - Research Site
  - Hershey, Pennsylvania, United States, 17033
    - Terminated
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19104
    - Recruiting
    - Research Site
  - Pittsburgh, Pennsylvania, United States, 15213
    - Recruiting
    - Research Site
  - Sayre, Pennsylvania, United States, 18840
    - Recruiting
    - Research Site
  - York, Pennsylvania, United States, 17403
    - Recruiting
    - Research Site
- South Carolina
  - Charleston, South Carolina, United States, 29425
    - Active, not recruiting
    - Research Site
  - Greenville, South Carolina, United States, 29605
    - Withdrawn
    - Research Site
  - Rock Hill, South Carolina, United States, 29732
    - Terminated
    - Research Site
  - Spartanburg, South Carolina, United States, 29303
    - Recruiting
    - Research Site
- South Dakota
  - Aberdeen, South Dakota, United States, 57401
    - Recruiting
    - Research Site
  - Sioux Falls, South Dakota, United States, 57105
    - Recruiting
    - Research Site
- Tennessee
  - Chattanooga, Tennessee, United States, 37404
    - Withdrawn
    - Research Site
  - Knoxville, Tennessee, United States, 37909
    - Recruiting
    - Research Site
  - Knoxville, Tennessee, United States, 37920
    - Recruiting
    - Research Site
  - Memphis, Tennessee, United States, 38120
    - Recruiting
    - Research Site
  - Nashville, Tennessee, United States, 37232
    - Recruiting
    - Research Site
  - Nashville, Tennessee, United States, 37203
    - Recruiting
    - Research Site
- Texas
  - Austin, Texas, United States, 78731
    - Recruiting
    - Research Site
  - Bedford, Texas, United States, 76022
    - Withdrawn
    - Research Site
  - Dallas, Texas, United States, 75246
    - Recruiting
    - Research Site
  - Dallas, Texas, United States, 75230
    - Withdrawn
    - Research Site
  - Dallas, Texas, United States, 75231
    - Withdrawn
    - Research Site
  - El Paso, Texas, United States, 79902
    - Recruiting
    - Research Site
  - Flower Mound, Texas, United States, 75028
    - Recruiting
    - Research Site
  - Houston, Texas, United States, 77030
    - Withdrawn
    - Research Site
  - Houston, Texas, United States, 77024
    - Recruiting
    - Research Site
  - Plano, Texas, United States, 75075
    - Withdrawn
    - Research Site
  - San Antonio, Texas, United States, 78217
    - Recruiting
    - Research Site
  - Tyler, Texas, United States, 75702
    - Recruiting
    - Research Site
- Utah
  - Salt Lake City, Utah, United States, 84112
    - Withdrawn
    - Research Site
- Virginia
  - Charlottesville, Virginia, United States, 22908
    - Recruiting
    - Research Site
  - Fairfax, Virginia, United States, 22031
    - Recruiting
    - Research Site
  - Midlothian, Virginia, United States, 23114
    - Recruiting
    - Research Site
  - Norfolk, Virginia, United States, 23502
    - Recruiting
    - Research Site
  - Richmond, Virginia, United States, 23219
    - Withdrawn
    - Research Site
  - Roanoke, Virginia, United States, 24014
    - Recruiting
    - Research Site
  - Winchester, Virginia, United States, 22601
    - Recruiting
    - Research Site
- Washington
  - Puyallup, Washington, United States, 98373
    - Recruiting
    - Research Site
  - Spokane, Washington, United States, 99202
    - Recruiting
    - Research Site
  - Vancouver, Washington, United States, 98684
    - Recruiting
    - Research Site
- West Virginia
  - Charleston, West Virginia, United States, 25304
    - Withdrawn
    - Research Site
  - Morgantown, West Virginia, United States, 26505
    - Recruiting
    - Research Site
- Wisconsin
  - Appleton, Wisconsin, United States, 54911
    - Recruiting
    - Research Site
  - Madison, Wisconsin, United States, 53792
    - Recruiting
    - Research Site
  - Milwaukee, Wisconsin, United States, 53215
    - Withdrawn
    - Research Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Women and Men; ≥18 years at the time of screening (or per national guidelines)
Histologically confirmed ER+/HER2- early-stage resected invasive breast cancer with absence of any evidence of metastatic disease as defined in the protocol.
Completed adequate (definitive) locoregional therapy (surgery with or without radiotherapy) for the primary breast tumour(s), with or without (neo)adjuvant chemotherapy.
Patients must be randomised within 12 months of definitive breast surgery.
Patients may have received up to 12 weeks of endocrine therapy prior to randomisation.
Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1
Adequate organ and bone marrow function

Exclusion Criteria:

Inoperable locally advanced or metastatic breast cancer
Pathological complete response following treatment with neoadjuvant therapy
History of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix or considered a very low risk of recurrence per investigator judgement) unless in complete remission with no therapy for a minimum of 5 years from the date of randomisation
Any evidence of severe or uncontrolled systemic diseases which, in the investigator's opinion precludes participation in the study or compliance "
Known LVEF <50% with heart failure NYHA Grade ≥2.
Mean resting QTcF interval > 480 ms at screening
Concurrent exogenous reproductive hormone therapy or non topical hormonal therapy for non-cancer-related conditions
Any concurrent anti-cancer treatment not specified in the protocol with the exception of bisphosphonates (e.g. zoledronic acid) or RANKL inhibitors ( eg, denosumab)
Previous treatment with camizestrant, investigational SERDs/investigational ER targeting agents, or fulvestrant
Currently pregnant (confirmed with positive serum pregnancy test) or breastfeeding.
Patients with known hypersensitivity to active or inactive excipients of camizestrant or drugs with a similar chemical structure or class to camizestrant. In pre-/peri-menopausal female and male patients, known hypersensitivity or intolerance to LHRH agonists that would preclude the patient from receiving any LHRH agonist.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Arm A: standard endocrine therapy of investigator´s choice ± abemaciclib standard endocrine therapy of investigator's choice (aromatase inhibitors [AI; exemestane, letrozole, anastrozole] or tamoxifen) ± abemaciclib	Drug: Tamoxifen Tamoxifen. Comparator. Administered orally Drug: Anastrozole Anastrozole. Comparator. Administered orally Drug: Letrozole Letrozole. Comparator. Administered orally Drug: Exemestane Exemestane. Comparator. Administered orally Drug: Abemaciclib Abemaciclib adjuvant treatment Administered orally
Experimental: Arm B: camizestrant ± abemaciclib camizestrant ± abemaciclib	Drug: Camizestrant Camizestrant. Experimental. Administered orally Other Names: AZD9833 Drug: Abemaciclib Abemaciclib adjuvant treatment Administered orally

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Invasive breast cancer-free survival (IBCFS) Time Frame: Up to 14 years	IBCFS is defined as time from randomisation until date of first occurrence of: Invasive ipsilateral breast tumour recurrence Locoregional invasive breast cancer recurrence Distant recurrence Contralateral invasive breast cancer Death attributable to any cause.	Up to 14 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Distant relapse-free survival (DRFS) Time Frame: Up to 14 years	DRFS is defined as time from randomisation until date of first distant recurrence or death from any cause, whichever occurs first.	Up to 14 years
Overall survival (OS) Time Frame: Up to 14 years	OS is defined as time from randomisation until death from any cause.	Up to 14 years
Incidence and Severity of Adverse Events, with Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI-CTCAE v5.0) Time Frame: Until 28 days after the final dose of study treatment (up to 7 years)		Until 28 days after the final dose of study treatment (up to 7 years)
Proportion of time on study treatment with high side-effect burden as measured by the PGI-TT. Time Frame: Until 28 days after the final dose of study treatment (up to 7 years)		Until 28 days after the final dose of study treatment (up to 7 years)
Invasive disease-free survival (IDFS) Time Frame: Up to 14 years	IDFS is defined as time from randomisation until date of first occurrence of one of the following events: Invasive ipsilateral breast tumor recurrence Locoregional invasive breast cancer recurrence Distant recurrence Contralateral invasive breast cancer Second primary non-breast invasive cancer Death attributable to any cause.	Up to 14 years
Change from baseline and time to deterioration of health-related quality of life as measured by the 2 global QoL items from the EORTC IL-311 Time Frame: Until 28 days after the final dose of study treatment (up to 7 years)		Until 28 days after the final dose of study treatment (up to 7 years)
Pharmacokinetics (PK) Time Frame: Until 6 months from treatment start	Plasma concentrations of camizestrant pre-dose (trough concentration)	Until 6 months from treatment start

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AstraZeneca

Collaborators

Austrian Breast & Colorectal Cancer Study Group

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Hamilton EP, Loibl S, Bachelot T, Gnant M, Niikura N, Park YH, Tolaney SM, Pistilli B, Rastogi P, Saini KS, Gioni I, Johnston S, Nunes R, Quintana A, Stuart M, Syta E, Walding A, Klinowska T, Mayer IA. CAMBRIA-1 & CAMBRIA-2 phase III trials: camizestrant versus standard endocrine therapy in ER+/HER2- early breast cancer. Future Oncol. 2025 Mar;21(7):795-806. doi: 10.1080/14796694.2025.2459548. Epub 2025 Feb 27.

Helpful Links

Breast Cancer Study Locator details (for US)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 5, 2023

Primary Completion (Estimated)

March 4, 2030

Study Completion (Estimated)

May 6, 2037

Study Registration Dates

First Submitted

May 17, 2023

First Submitted That Met QC Criteria

July 11, 2023

First Posted (Actual)

July 19, 2023

Study Record Updates

Last Update Posted (Actual)

June 25, 2026

Last Update Submitted That Met QC Criteria

June 24, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

D8535C00001
2023-504031-41-00 (Registry Identifier: CTIS (EU))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

IPD Sharing Time Frame

AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please refer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

IPD Sharing Access Criteria

When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool. Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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National University Hospital, Singapore

Enrolling by invitation

Trial to Evaluate the Impact of Various Pragmatic Interventions to Increase Mammography Uptake Among Defaulted Repeat Screeners in Singapore (REMIND1)

Breast Cancer | Breast Neoplasm | Early Detection of Cancer | Mammography Screening | Mammogram Uptake | Early Breast Cancer Detection

Singapore
Lucía Graña López

Recruiting

Luminal Breast Cancer Cryoablation (LUBRECA)

Breast Cancer | Breast Cancer (Early Breast Cancer)

Spain
The Netherlands Cancer Institute
BOOG Study Center; Stichting Treatmeds; Zorgevaluatie en Gepast Gebruik (ZE&GG); Integraal Kankercentrum Nederland (IKNL)

Not yet recruiting

Pembrolizumab Adjuvant in Patients With Early-stage Triple Negative Breast Cancer With Residual Disease After Neoadjuvant Pembrolizumab Plus Chemotherapy (PLANET)

Breast Cancer Stage II | Breast Cancer Stage III | Triple -Negative Breast Cancer | Early Stage Triple-Negative Breast Carcinoma | Triple Negative Breast Cancer (TNBC), Early Setting
University Hospital Tuebingen

Recruiting

Praegnant Breast Cancer: Early/Advanced/Metastatic (PRAEGNANT)

Advanced/Metastatic Breast Cancer | Breast Cancer (Early Breast Cancer)

Germany
M.D. Anderson Cancer Center

Recruiting

Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Early Stage Triple-Negative Breast Carcinoma | Early Stage HER2-Positive Breast Carcinoma

United States

Clinical Trials on Camizestrant

AstraZeneca

Recruiting

Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer (SERENA-1b)

Advanced Breast Cancer

United States, United Kingdom
AstraZeneca

Completed

Study to Investigate Hepatic Impairment on PK, Safety, Tolerability of Camizestrant in Post-Menopausal Female Subjects

Hepatic Impairment

United States, Bulgaria, Slovakia
MedSIR

Recruiting

Efficacy and Safety of Camizestrant Plus Ribociclib in Patients With Breast Cancer (CADILLAC)

Breast Cancer | Hormon Receptor Positive Breast Cancer

Spain, Germany
AstraZeneca
ICON plc

Recruiting

A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer (SERAFA-1)

ER-Positive HER2-Negative Breast Cancer

Spain, Italy, France, Germany, Switzerland, Poland, United States, South Korea
AstraZeneca

Recruiting

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors (CYCAD-1)

ER+ HER2- Advanced Breast Cancer | High-grade Serous Ovarian Cancer (HGSOC)

United States, United Kingdom, Spain, Australia, South Korea
AstraZeneca

Active, not recruiting

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies (PETRA)

Cervical Cancer | Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Biliary Cancer | Additional Indications Below for Module 4 and 5 | Small Cell Lung Cancer Only in Module 5

Italy, Spain, United States, Canada, Czechia, Poland, China, United Kingdom, Ukraine, Hungary, Australia, South Korea, Japan, Russia
AstraZeneca

Completed

A Study to Investigate the Pharmacokinetics of Midazolam After Repeated Doses of Camizestrant (AZD9833) and to Investigate the Pharmacokinetics of Camizestrant When Administered Alone and in Combination With Carbamazepine in Healthy Post-Menopausal Female Participants

Healthy Participants

United Kingdom
AstraZeneca

Recruiting

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy (CAMBRIA-1)

Breast Cancer, Early Breast Cancer

Japan, Germany, United States, Taiwan, Belgium, Poland, Thailand, Brazil, Canada, United Kingdom, India, China, Hungary, Israel, Austria, Bulgaria, South Africa, France, Australia, Mexico, Spain, Argentina, Greece, Malaysia, Peru, Philipp... and more
AstraZeneca
Parexel

Completed

A Study to Assess the Pharmacokinetics of Camizestrant (AZD9833) When Administered Alone and in Combination With Itraconazole

Healthy Subjects

United Kingdom
AstraZeneca

Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer (EvoPAR-BR01)

Advanced Breast Cancer

China, United States, Hungary, Spain, Germany, Italy, Peru, United Kingdom, France, Brazil, Malaysia, Taiwan, Thailand, Israel, Australia, Austria, Canada, Bulgaria, India, Japan, Poland, Czechia, Portugal, Hong Kong, Argentina, Puerto Rico, Chi... and more

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) (CAMBRIA-2)

Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

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Study Locations

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Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

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Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

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Time Frame

Collaborators and Investigators

Sponsor

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Primary Completion (Estimated)

Study Completion (Estimated)

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First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

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Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

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Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Breast Cancer, Early Breast Cancer

Clinical Trials on Camizestrant

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