Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders (IHMS)

Research of Intracardiac Hemodynamics and Myocardial Strains of Athlete's Heart

The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions. The main questions aim to answer are: 1. whether an increase in amplitude and duration of intracardiac hemodynamics and myocardial strain compared with healthy controls; 2. Whether significant correlations exist between the hemodynamic indices and training level.

Participants will be asked to filling out the questionnaire, such as the age, training year (the number of years the athlete has participated in any sport), technical hierarchy (promoted by the Competitive Sports Department of the General Administration of Sport of China, weekly training time in the last 6 months, height, weight, body surface area, heart rate, systolic blood pressure, and diastolic blood pressure; and will be asked to perform an examination of transthoracic echocardiography.

Researchers will compare differences of cardiac structure and function, especially the hemodynamics and myocardial strain to see if training level could affect the cardiac function through hemodynamics and myocardial strain.

Study Overview

• Status: Completed
• Conditions: Cardiac Structure and Function; Intracardiac Hemodynamic
• Intervention / Treatment: Behavioral: exercise

• Study Type: Observational
• Enrollment (Actual): 120

Contacts and Locations

Study Locations

• China
  • Sichuan
    • Chengdu, Sichuan, China, 610041
      • Chengdu Sport University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

athletes with training year > 10 and WTT > 20, athletes with training year < 10 and WTT < 20, healthy controls with irregular exercise habits

Description

Inclusion Criteria:

• athletes and healthy control subjects without regular exercise habits;
• no specific medical history or chronic illness.

Exclusion Criteria:

• A previous history of arterial hypertension, diabetes mellitus, heart, kidney, hepatic, infectious, psychiatric, malignant, disorders, taking drugs that can influence ECG intervals, and electrolyte imbalance;
• poor echocardiographic image quality and abnormal segmental ventricular wall movement.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
elite athlete; training year > 10 years and weekly training time > 20 hours	Behavioral: exercise; Exercise intervention according to the training program; Other Names: exercise training
casual player; training year < 10 years and weekly training time < 20 hours	Behavioral: exercise; Exercise intervention according to the training program; Other Names: exercise training
healthy control; healthy participants with irregular exercise habits	Behavioral: exercise; Exercise intervention according to the training program; Other Names: exercise training
first responder; first responders with regular exercise training	Behavioral: exercise; Exercise intervention according to the training program; Other Names: exercise training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
intracardiac hemodynamics in mmHg/mm using vector flow mapping	intraventricular pressure gradient from left ventricular apex to base	through study completion, an average of 1 year
myocardial strain in % using two-dimension tissue tracking	left ventricular longitudinal strain	through study completion, an average of 1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
wall shear stress in pascal using vector flow mapping	segmental wall shear stress of the left ventricle	through study completion, an average of 1 year

Collaborators and Investigators

• Sponsor: Chengdu Sport University
• Collaborators: Institute of Sports Medicine, General Administration of Sport of China

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2021
• Primary Completion (Actual): July 30, 2023
• Study Completion (Actual): July 30, 2024

Study Registration Dates

• First Submitted: September 26, 2023
• First Submitted That Met QC Criteria: October 3, 2023
• First Posted (Actual): October 10, 2023

Study Record Updates

• Last Update Posted (Actual): July 30, 2024
• Last Update Submitted That Met QC Criteria: July 29, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Other Study ID Numbers: IHMS; 2019YFF0301704 (Other Identifier: National Key Research and Development Program (China))

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES