The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

November 8, 2023 updated by: University of Exeter

The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • BMI between 18 - 30
  • Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)

Exclusion Criteria:

  • Any metabolic impairment
  • Any cardiovascular impairment
  • Smoking
  • Lactose intolerance
  • Allergies to products containing dairy, meat or nuts
  • Prescribed intake of over the counter pharmaceuticals

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Whey protein isolate
Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate
Behavioral: Bilateral resistance exercise
A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension
Dietary supplement: Whey protein
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate
Experimental: Plant-blend isolate
Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate
Behavioral: Bilateral resistance exercise
A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension
Dietary supplement: Plant-blend protein
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Post-exercise myofibrillar protein synthesis following protein ingestion
Time Frame: 4 hours
The fractional synthetic rate of myofibrillar proteins
4 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Post-exercise myofibrillar protein synthesis during the early postprandial period
Time Frame: 2 hours
The fractional synthetic rate of myofibrillar proteins
2 hours
Post-exercise myofibrillar protein synthesis during the late postprandial period
Time Frame: 2 hours
The fractional synthetic rate of myofibrillar proteins
2 hours
Plasma amino acid response
Time Frame: 4 hours
Post-exercise and postprandial change in plasma amino acid concentrations and availability
4 hours
Serum insulin response
Time Frame: 4 hours
Post-exercise and postprandial change in serum insulin concentrations
4 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Exeter

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 24, 2022

Primary Completion (Actual)

October 31, 2022

Study Completion (Actual)

October 31, 2022

Study Registration Dates

First Submitted

September 20, 2023

First Submitted That Met QC Criteria

November 8, 2023

First Posted (Actual)

November 13, 2023

Study Record Updates

Last Update Posted (Actual)

November 13, 2023

Last Update Submitted That Met QC Criteria

November 8, 2023

Last Verified

November 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 22-02-02-B-02

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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