Respiratory Sarcopenia in Institutionalized Older Adults in the Region of Murcia

Respiratory Sarcopenia in Institutionalized Older Adults in the Region of Murcia: Prevalence and Associated Factors

Objectives: The objectives of this study are to describe the prevalence of respiratory sarcopenia in institutionalized older adults. Methodology: A sample of approximately 120 older adults from 5 residences located in Murcia capital will participate in the study. A prospective observational study will be carried out, with one year of follow-up, with patients who have been diagnosed with respiratory sarcopenia. Sociodemographic and clinical variables, physical function (palm grip, 5STS, 4MGS), respiratory force variables (MIP and PEF) and diaphragmatic ultrasound (thickness, shortening fraction and diaphragmatic excursion) will be measured. Descriptive statistics, univariate and multivariate logistic regression models, Cox proportional hazards model and KaplanMeier curves will be used to analyze the data from the longitudinal study.

Study Overview

• Status: Completed
• Conditions: Sarcopenia; Respiratory Function Impaired

• Study Type: Observational
• Enrollment (Actual): 127

Contacts and Locations

Study Locations

• Spain
  • Murcia, Spain
    • Residence of the elderly

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Institutionalized elderly diagnosed with respiratory sarcopenia

Description

Inclusion Criteria:

• To have functional ambulation and/or wheelchair.
• preserved cognitive status.
• have sufficient ability to Oral occlusion for carrying out respiratory tests.

Exclusion Criteria:

• presence of respiratory diseases or in treatment of respiratory diseases.
• serious orthopedic diseases that interfere with measurements and those with a diagnosis of dementia.
• those who present any contraindication for carrying out the procedure will be excluded.
• of the respiratory pressure measurement tests, as established in the SEPAR guidelines.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Wheelchair; The inclusion criteria to participate in the study are being in a wheelchair, preserved cognitive status and having sufficient ability to Oral occlusion for carrying out respiratory tests. The exclusion criteria are following: presence of respiratory diseases or in treatment of respiratory diseases, serious orthopedic diseases that interfere with measurements and those with a diagnosis of dementia. In addition, those who present any contraindication for carrying out the procedure will be excluded. of the respiratory pressure measurement tests, as established in the SEPAR guidelines. The objectives of the study and the methodology to be used will be explained to all participants. An information sheet will be provided and the informed consent sheet will be given to them.
wanderers; The inclusion criteria to participate in the study are to have functional ambulation, preserved cognitive status and have sufficient ability to Oral occlusion for carrying out respiratory tests. The exclusion criteria are following: presence of respiratory diseases or in treatment of respiratory diseases, serious orthopedic diseases that interfere with measurements and those with a diagnosis of dementia. In addition, those who present any contraindication for carrying out the procedure will be excluded. of the respiratory pressure measurement tests, as established in the SEPAR guidelines. The objectives of the study and the methodology to be used will be explained to all participants. An information sheet will be provided and the informed consent sheet will be given to them.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Sociodemographic	Sociodemographic dates	8 MONTHS
Clinical variables	Clinical variables will be extracted from history clinic	8 MONTHS
Palm grip strength	Palm grip strength will be measured with the digital hand dynamometer (Jamar©). The Participants will remain seated with the shoulder in 0° adduction; elbow flexed 90° and forearm in neutral position. Three attempts will be made and the best value will be chosen	8 MONTHS
5 SIT TO STAND	The 5STS test measures the time (in seconds) it takes a subject to stop 5 times from a sitting position, as quickly as possible.	8 MONTHS
4 METRES	The gait speed test (4MGS) measures the time it takes to cross a line of 4m at normal speed.	8 MONTS
Body composition	- The analysis of body composition will be carried out with the TANITA MC 780-P MA monitor, which provides information on visceral and body fat, skeletal muscle level, BMI and basal metabolism.	8 MONTHS
Respiratoy muscle force	To measure respiratory muscle force, the maximum respiratory pressures will be evaluated in mouth (PIM/PEM). For them we will use an inspiratory and expiratory mouth pressure monitor maximum, a module of the Datapir touch© spirometer (Sibelmed, Barcelona). The measurement will be performed by a previously trained and experienced physiotherapist, following the protocol established by the Spanish Society of Pulmonology (4-SEPAR).	8 MONTHS
Diaphragmatic ultrasound variables	The diaphragmatic ultrasound variables examined will be mobility, thickness and fraction of shortening. For this we will use the Esaote MyLab™ Sigma ultrasound machine (Esaote SpA, Genoa, Italy), with double probe (linear and convex).	8 MONTHS

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Health results	The health outcome variables that will be recorded over a year will be: infections respiratory diseases, visit to the emergency department, hospitalization, bedridden and/or death. This Information will be extracted from the patient's clinical record.	8 MONTHS

Collaborators and Investigators

• Sponsor: Felipe León Morillas

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2023
• Primary Completion (Actual): December 31, 2023
• Study Completion (Actual): July 31, 2025

Study Registration Dates

• First Submitted: October 30, 2023
• First Submitted That Met QC Criteria: November 8, 2023
• First Posted (Actual): November 14, 2023

Study Record Updates

• Last Update Posted (Actual): August 20, 2025
• Last Update Submitted That Met QC Criteria: August 15, 2025
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Keywords: sarcopenia; institutionalized elderly; respiratory force
• Additional Relevant MeSH Terms: Neurologic Manifestations; Nervous System Diseases; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Respiratory Tract Diseases; Respiration Disorders; Muscular Atrophy; Atrophy; Respiratory Insufficiency; Sarcopenia
• Other Study ID Numbers: SarcoRespi

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No