Accuracy of IVCCI as a Measure of CVP

Accuracy of Inferior Vena Cava Collapsibility Index as a Measure of Central Venous Pressure

The primary aim of the current study is to examine the accuracy of IVCCI for measurement of CVP and to derive equation or formula to predict CVP from IVCCI.

Study Overview

• Status: Completed
• Conditions: IVC Collapsibility Index

Detailed Description

Hemodynamic monitoring is important in the management of patients in the intensive care unit (ICU) Assessment of the intravascular volume, infusion of fluids or vasoactive drugs and maintenance of an adequate systemic perfusion is essential for reduction of the risk of organ failure and/or mortality.

The use of CVP through central venous catheter is a gold standard method that is extensively used in the ICU as it reflects the filling pressure of the right ventricle (RV) and RV preload.

Central venous cannulation has significant complications such as pneumothorax, hemothorax, arterial puncture, catheter malposition, cardiac arrhythmias, venous embolism, subcutaneous hematoma, and catheter related infection, and it is difficult to use this method in an emergency situation as it requires skilled personnel.

Measurement of IVC index by bedside ultrasound is widely used to assess the intravascular volume in adult patients and has the advantage of being non-invasive, rapid, and reliable for assessing the volume status.

Besides, related measures such as IVC diameter, IVC collapsibility, and IVC to aorta (AO) diameter have been applied clinically to assess the volume status and have been related to CVP.

• Study Type: Observational
• Enrollment (Actual): 160

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 11517
    • Department of Anesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain Shams University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to ICU

Description

Inclusion Criteria:

• Age: ≥18 years.
• Sex: Both sexes.
• BMI: <35
• Patient in whom central venous cannulation is needed for management.
• Spontaneously breathing patients.

Exclusion Criteria:

• Patients with increased intra abdominal pressure.
• Patients who not able to lie supine.
• Patients on mechanical ventilation.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Derivation Sample; 80 patients will be recruited as a derivation sample to calculate the regression equation
Validation Sample; 80 patients will be recruited as a validation sample to test the performance of the equation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The primary outcome of the current study is to examine the accuracy of IVCCI for measurement of CVP and to derive equation or formula to predict CVP from IVCCI.	18 months

Collaborators and Investigators

• Sponsor: Nermeen Shawky Ahmed Mohamed

Study record dates

Study Major Dates

• Study Start (Actual): December 15, 2023
• Primary Completion (Actual): April 30, 2025
• Study Completion (Actual): April 30, 2025

Study Registration Dates

• First Submitted: December 4, 2023
• First Submitted That Met QC Criteria: December 4, 2023
• First Posted (Actual): December 12, 2023

Study Record Updates

• Last Update Posted (Actual): May 28, 2026
• Last Update Submitted That Met QC Criteria: May 24, 2026
• Last Verified: May 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: MD186/2023

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No