SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS

Joint mobilization and resistance exercise training are effective conservative treatment options for the management of osteoarthritis. However, currently no study has highlighted the supplementary effects of resistance training in addition to joint mobilization in people suffering from knee osteoarthritis. The current study is aimed at bridging the gap in literature and providing evidence regarding the additive impact of resistance training to joint mobilization in knee osteoarthritis.

Study Overview

• Status: Enrolling by invitation
• Conditions: Knee Osteoarthritis
• Intervention / Treatment: Procedure: Joint Mobilization; Device: Transcutaneous Electric Nerve Stimulation (TENS); Device: Heating Pad; Procedure: Resistance Exercise Training

• Study Type: Interventional
• Enrollment (Estimated): 44
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Pakistan
  • Islamabad, Pakistan
    • Foundation Univeristy Islamabad

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Knee OA grade I-III
• Individuals of either gender aged 40-70 years
• Knee OA history of no less than 3 months
• Knee pain no more than 8/10 cm on the visual analogue scale (VAS)
• Radiological evidence of grade III or less on Kellgren classification.

Exclusion Criteria:

• Those with signs of serious pathology such as malignancy, inflammatory disorder or infection.
• History of trauma or fractures in lower extremity
• Signs of lumbar radiculopathy or myelopathy
• History of knee surgery or replacement and/or receiving intra-articular steroid therapy in the preceding two months

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental Group	Procedure: Joint Mobilization; Patellofemoral and tibiofemoral joint mobilization; Device: Transcutaneous Electric Nerve Stimulation (TENS); Transcutaneous Electric Nerve Stimulation (TENS); Device: Heating Pad; Heating pad for heat therapy; Procedure: Resistance Exercise Training; Lower limb resistance exercise training
Active Comparator: Active Comparator	Procedure: Joint Mobilization; Patellofemoral and tibiofemoral joint mobilization; Device: Transcutaneous Electric Nerve Stimulation (TENS); Transcutaneous Electric Nerve Stimulation (TENS); Device: Heating Pad; Heating pad for heat therapy

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Walking related performance fatigability	Walking related performance fatigability will be measured using 6 minute walk test. Greater fatigability indicates poorer outcome.	4 weeks
Stride Length	Gait analysis will be done to analyze stride length. A greater stride length signifies positive outcome and prognosis.	4 weeks
Gait velocity	Gait analysis will be done to analyze gaot velocity. A greater gait velocity signifies positive outcome and prognosis.	4 weeks
Knee Pain	Knee Pain will be measured using visual analogue scale (VAS) from 0-100mm. A higher score on VAS indicated greater pain.	4 weeks
Knee range of motion	Knee range of motion will be measured using a goniometer. A higher ROM signifies positive outcome.	4 weeks
Functional Disability	Knee functional disability will be assessed using Knee Osteoarthritis and Outcome Score (KOOS) with a score ranging from 0-100. A lower score on KOOS signifies greater functional disability.	4 weeks
Isometric Muscle Strength	Isometric Muscle Strength will be quantified using dynamometer. A higher score on dynamometer signifies greater muscle strength and good prognosis.	4 weeks
Functional capacity	5 repetition sit to stand test will be used to determine knee related functional capacity, which will be quantified in terms of time. A smaller time will denote greater functional capacity.	4 weeks

Collaborators and Investigators

• Sponsor: Foundation University Islamabad
• Investigators: Principal Investigator: Muhammad Osama, PhD*, Foundation University Islamabad; Principal Investigator: Wania Maheen, DPT, Foundation University Islamabad

Study record dates

Study Major Dates

• Study Start (Estimated): June 10, 2024
• Primary Completion (Estimated): December 10, 2024
• Study Completion (Estimated): December 30, 2024

Study Registration Dates

• First Submitted: May 27, 2024
• First Submitted That Met QC Criteria: June 5, 2024
• First Posted (Actual): June 6, 2024

Study Record Updates

• Last Update Posted (Actual): June 6, 2024
• Last Update Submitted That Met QC Criteria: June 5, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis; Osteoarthritis, Knee
• Other Study ID Numbers: FUI/CTR/2024/12

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No