Mobility Assessment in Multi-morbidity (Multi-mobility)

June 18, 2024 updated by: Ioannis Vogiatzis, Northumbria University

Walking-related Mobility Assessment in Older People With Multimorbidity

Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare costs. Over 50% of adults >65 years have multiple long-term conditions (MLTCs).

Our group has validated a broad range of algorithms applied to single wearable sensors that have the potential to capture walking-related mobility outcomes (such as walking cadence and walking speed) accurately and reliably during activities of daily living across five single long-term conditions. These algorithms, however, cannot be readily applied to people with MLTCs because the effect of multimorbidity on mobility is amplified compared to single long-term conditions secondary to a greater number of complications and sequelae. Accordingly, the aim of this study is to validate algorithms that would allow robust estimation of walking-related mobility outcomes during daily life activities in MLTCs.

To meet our objectives, the investigators will perform: i) laboratory-based technical validation of existing and newly developed algorithms for walking-related mobility outcome detection; ii) unsupervised real-life validation of selected algorithms; and iii) examination of how well the validated walking-related mobility outcomes reflect global and disease specific characteristics in older adults with multimorbidity. The investigators will adopt an integrated patient-centric approach where patients with MLTCs will be engaged early in the project to provide input of their perception and concerns regarding mobility limitation in daily life activities.

The investigators aim to recruit 55 older adults (>65 years), men and women, with multiple long-term conditions with the following inclusion criteria: having two or more of the following conditions including osteoarthritis, rheumatoid arthritis, osteoporosis, type 2 diabetes, depression and/or anxiety, hypertension, coronary heart disease, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, asthma, bronchiectasis, chronic kidney disease, cancer, or stroke within the last 5 years.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Ioannis Vogiatzis, PhD
Phone Number: +44 (0)191 349 5446
Email: ioannis.vogiatzis@northumbria.ac.uk

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Older Adult

Accepts Healthy Volunteers

Sampling Method

Non-Probability Sample

Study Population

Patients will be recruited from outpatient clinics within the Newcastle upon Tyne Hospitals NHS Foundation Trust.

Description

Inclusion Criteria:

Adults ≥65 years old
Able and willing to provide informed consent
Able to read and write in English
To be mobile (including the use of walking aids)
Two or more of the following long terms conditions: Arthritis, Asthma, Atrial fibrillation, Bronchiectasis, Cancer, Chronic kidney disease, Chronic obstructive pulmonary disease, Coronary heart disease, Anxiety, Depression, Diabetes mellitus, Heart failure, Hypertension, Osteoporosis, Parkinson's disease, Peripheral vascular disease, Stroke or transient ischaemic attack

Exclusion Criteria:

Unable to give consent for the study
Severe mental health problems
Active malignancy (on chemotherapy/radiotherapy/planned urgent surgery)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cadence Time Frame: 7-day real world assessment	Walking cadence measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in steps/minute.	7-day real world assessment
Stride length Time Frame: 7-day real world assessment	Stride length measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in meters.	7-day real world assessment
Walking speed Time Frame: 7-day real world assessment	Walking speed measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in m/s.	7-day real world assessment
Stride duration Time Frame: 7-day real world assessment	Stride duration measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in sec.	7-day real world assessment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Turning angle Time Frame: 7-day real world assessment	Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist expressed in deg/s.	7-day real world assessment
Daily steps Time Frame: 7-day real world assessment	Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist expressed in steps/day.	7-day real world assessment
Sedentarism Time Frame: 7-day real world assessment	Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist indicating time spent in different types of activities such as sitting down, lying, and walking expressed in minutes per day.	7-day real world assessment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northumbria University

Collaborators

Newcastle University

Investigators

Study Chair: Laura Hutchinson, BSc, Northumbria University Newcastle

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2024

Primary Completion (Estimated)

October 31, 2025

Study Completion (Estimated)

December 31, 2025

Study Registration Dates

First Submitted

June 7, 2024

First Submitted That Met QC Criteria

June 18, 2024

First Posted (Actual)

June 25, 2024

Study Record Updates

Last Update Posted (Actual)