Effect of Aerobic Exercise Versus Resistance Exercise on Bone Density in Postmenopausal Diabetic Women

September 20, 2025 updated by: Deraya University

Effect of Moderate Intensity Aerobic Exercise Versus Resistance Exercise on Bone Density in Postmenopausal Diabetic Women

Osteoporosis is a significant public health issue, especially among postmenopausal women with diabetes, and its prevalence is increasing. This trial aims to determine the influence of moderate intensity aerobic exercise vs resistance exercise on bone mineral density among postmenopausal diabetic women.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

has diabetes. Postmenopausal Osteoporosis (PMO) is an increasingly serious metabolic bone disease in the world, which generally develops in middle-aged and elderly women and postmenopausal women, and it is characterized by low bone mass and microstructure degradation of bone tissues. there are complex pathophysiological effects between them: T2D directly affects bone metabolism and strength. Some antidiabetic drugs affect bone metabolism, and diabetes complications are related to the risk of falls and subsequent fractures. Patients with T2D have higher trabecular and lower cortical bone density, leading to lower bone intensity. Exercise is considered a highly relevant component in the prevention and treatment of osteoporosis and fracture reduction. Exercise greatly affects bone geometry as it increases periosteal apposition through increasing osteoblast formation. In addition to influencing bone mineral density, exercise can improve muscle function to potentially decrease fall risk through improved balance and strength.

The purpose of this study was to investigate the effect of moderate-intensity aerobic exercise versus resistance exercise on bone mineral density in postmenopausal diabetic women.

Study Type

Interventional

Enrollment (Actual)

50

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Minya, Egypt, 05673
        • Soad A. Mohamad

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Fifty women postmenopausal obese women
  • (BMI) 30 -35 kg/m2
  • their age ranges from 50 to 60 years old and
  • complain of diabetic type 2 for 10 years ago.

Exclusion Criteria:

  • women with renal or liver disease,
  • cardiac or chest disease psychological problems,
  • cognitive problems are excluded from the study.
  • Any women who have therapeutic problems that will interfere with performing exercise or affection BMD will be excluded from this study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group (A)
25 patients receive aerobic exercise attended the program of walking on a treadmill machine for eight weeks according to specific parameters, in addition to their usual daily calcium intake.
Procedure: aerobic exercise

aerobic exercise.

  • Intensity: according to heart rate (60-75% of maximum heart rate) MHR=220-age.
  • Heart rate: determined by the sensor of a treadmill.
  • Duration: 40-50 min per session. Each session consisted of 5-10 minutes of warming up exercise on a treadmill without increasing speed or intensity and the same for the cooling down phase. There was 30 minutes of conditioning exercise including increasing the treadmill speed till reaching (60-75%) of the maximum heart rate.
  • Frequency: 3 times/week for 12 weeks in addition to their usual daily calcium intake.
Procedure: resistance exercise
resisted exercise program for 12 weeks
Active Comparator: Group (B)
25 patients receive resisted exercise in addition to their usual daily calcium intake for 12 weeks.
Procedure: aerobic exercise

aerobic exercise.

  • Intensity: according to heart rate (60-75% of maximum heart rate) MHR=220-age.
  • Heart rate: determined by the sensor of a treadmill.
  • Duration: 40-50 min per session. Each session consisted of 5-10 minutes of warming up exercise on a treadmill without increasing speed or intensity and the same for the cooling down phase. There was 30 minutes of conditioning exercise including increasing the treadmill speed till reaching (60-75%) of the maximum heart rate.
  • Frequency: 3 times/week for 12 weeks in addition to their usual daily calcium intake.
Procedure: resistance exercise
resisted exercise program for 12 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The bone mineral density (BMD)
Time Frame: 3 months
• Dual Energy X-ray Absorptiometry (DEXA). It was used to measure the bone mineral density (BMD) of the lumbar spine for each woman in both groups before and after the study.
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Deraya University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 10, 2024

Primary Completion (Actual)

June 22, 2024

Study Completion (Actual)

August 1, 2024

Study Registration Dates

First Submitted

July 2, 2024

First Submitted That Met QC Criteria

July 10, 2024

First Posted (Actual)

July 17, 2024

Study Record Updates

Last Update Posted (Estimated)

September 23, 2025

Last Update Submitted That Met QC Criteria

September 20, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Physical Therapy

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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