Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia

Multidimensional Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia

Based on the preoperative ultrasound detection of various parametric indicators of the inferior vena cava cross-section, including the ratio of the inferior vena cava's long and short axes, cross-sectional area and circumference during two-dimensional and three-dimensional imaging, as well as the changes in respiratory variability of each parameter, we explored the predictive value of IVC ultrasound indicator parameters on hypotension after induction of general anesthesia in elderly patients undergoing elective non-cardiac surgery, screened the sensitive indicators, and calculated the cut-off values.

Study Overview

• Status: Not yet recruiting
• Conditions: Elderly Patients Undergoing Elective Non-cardiac Surgery
• Intervention / Treatment: Diagnostic test: Multidimensional ultrasound of the inferior vena cava

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: zhuan zhang, professor; Phone Number: +8615062791355; Email: zhangzhuancg@163.com

Study Locations

• China
  • Jiangsu
    • Yangzhou, Jiangsu, China
      • the Affiliated Hospital of Yangzhou University, Yangzhou University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Elderly patients undergoing elective non-cardiac surgery under general anesthesia

Description

Inclusion Criteria:

• Elderly patients undergoing elective non-cardiac surgery under general anesthesia;
• Age 65-85 years old;
• Body mass index (BMI) 18-28 kg/m2;
• American society of anesthesiologists (ASA) class I-III.

Exclusion Criteria:

• Patient refusal or lack of cooperation;
• Inability to communicate properly;
• Severe sinus bradycardia, pacemaker implantation, atrioventricular block, and atrial fibrillation;
• Presence of severe hepatic and renal function abnormalities;
• Preoperative cardiac ultrasound suggesting LVEF <50%;
• Tricuspid valve displacement <16 mm by preoperative cardiac ultrasound;
• Chronic obstructive pulmonary disease;
• Pulmonary hypertension;
• Administration of drugs that inhibit the renin-angiotensin-aldosterone system;
• Possibility of a difficult airway.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Elderly patients undergoing elective noncardiac surgery under general anesthesia	Diagnostic test: Multidimensional ultrasound of the inferior vena cava; Cross-sectional parameters of the inferior vena cava include two-dimensional longitudinal diameter, cross-sectional length and short diameter, circumference, and cross-sectional area, as well as cross-sectional length and short diameter, circumference, and cross-sectional area in three-dimensional imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in the level of Mean Arterial Pressure	The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction	Baseline (before induction), 10 min after induction
Changes in the level of Systolic Blood Pressure	The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction	Baseline (before induction), 10 min after induction
Multidimensional ultrasound of the inferior vena cava	The outcome above should be measured at the time before induction	Baseline (before induction)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in the level of Heart Rate	The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction	Baseline (before induction), 10 min after induction
Changes in the level of Diastolic Blood Pressure	The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction	Baseline (before induction), 10 min after induction

Collaborators and Investigators

• Sponsor: Zhuan Zhang
• Investigators: Principal Investigator: zhuan zhang, professor, The Affiliated Hospital of Yangzhou University

Study record dates

Study Major Dates

• Study Start (Estimated): September 1, 2024
• Primary Completion (Estimated): March 31, 2025
• Study Completion (Estimated): March 31, 2025

Study Registration Dates

• First Submitted: July 28, 2024
• First Submitted That Met QC Criteria: July 28, 2024
• First Posted (Actual): July 31, 2024

Study Record Updates

• Last Update Posted (Estimated): August 5, 2024
• Last Update Submitted That Met QC Criteria: August 1, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Keywords: general anesthesia; hypotension; inferior vena cava
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypotension
• Other Study ID Numbers: 20240725

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No