AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma

An Exploratory Phase II Study of Neoadjuvant Treatment With AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma

This exploratory phase II study is designed to enroll patients with operable locally advanced head and neck squamous cell carcinoma, to observe the efficacy and safety of AK112 combined with chemotherapy as neoadjuvant therapy on them.

Study Overview

• Status: Not yet recruiting
• Conditions: Neoadjuvant Therapy of Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
• Intervention / Treatment: Drug: AK112

Detailed Description

This exploratory phase II study is designed to enroll 36 patients with operable locally advanced head and neck squamous cell carcinoma(defined according to 8th teh edition of AJCC Guideline). The patients are given 3cycles of AK112(20mg/Kg per cycle) combined with AP regimen(platinum based chemotherapy), with a 3-week interval between each cycle (d1,d22,d43). After 3 cycles' therapy, if the volume of primary tumor decreases by over 50%，the range of resection operation will be conducted by the actual range of tumor, or else the surgery will be conducted by the original range of the tumor. The adjuvant radiation therapy would be conducted in 4-6 weeks after the surgery, while the adjuvant therapy of AK112 would be given in 21days after the surgery for 14 cycles. The process will continue until disease progression or uncontrolled toxicity. The primary endpoint is pCR(pathological complete response) and 2y-EFS; the secondary endpoint is MPR(Main pathological response)、ORR(objective response rate)、2y-OS(overall survival)、organ retention rate and safety assessment.

• Study Type: Interventional
• Enrollment (Estimated): 36
• Phase: Phase 2

Contacts and Locations

• Study Contact: Name: kunyu yang, doctor; Phone Number: 13429829986; Email: wenlu@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Age 18-70 years, regardless of sex;
2. histological diagnosis of squamous cell carcinoma in oral cavity,oropharynx, hypopharynx or laryngeal;
3. preoperative evaluation turns to be operatable;
4. locally advanced, according to the American Joint Committee on Cancer ( AJCC -RSB- guidelines, 8th edition),HPV status is determined by p16 immunohistochemistry (IHC);
5. Have not received prior treatment for head and neck squamous cell carcinoma;
6. Have at least one evaluable target lesion according to RECIST version 1.1;
7. ECOG physical condition 0-1 point;

8. The function of the major organs is normal, which meets the following criteria(not receiving blood transfusion in 14 days):

   a. Hb(hemoglobin)≥90g/L:b. ANC(Neutrophils)≥1.5x109/L; c. PLT(platelet)≥80x109／L；

   The biochemical tests should meet the following criteria:

   a.BIL(bilirubin)< 1.25 times the upper limit of normal (ULN); b.ALT(Alanine aminotransferase) and AST(Aspartate aminotransferase)<2.5xULN; c.Serum CR(creatinine) ≤ ULN, endogenous creatinine clearance > 50 ml/min (Cockcroft-Gaut formula) ;

9. Sign a written informed consent form before performing any test related activities;
10. The researchers judged that they were able to comply with the study protocol;
11. Pregnancy test (for fertile women) was negative at screening;
12. Fertile male patients as well as fertile female patients at risk of fertility and pregnancy had to agree to use 2 contraceptive methods throughout the study period (at least one of which was considered to be an efficient contraceptive method) .
13. Patients who are willing and able to follow visiting schedules, treatment plans, laboratory tests, and other research procedures.

Exclusion Criteria:

1. Previously received immunotherapy with anti-PD-1(programmed cell death receptor-1), anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibodies (including ipilimumab) or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways;
2. Previously received prior chemotherapy or antiangiogenic therapy;
3. Received major surgery ≤4 weeks before admission;
4. Carrying any active autoimmune disease or history of autoimmune disease'
5. Previous or concurrent getting cancers (except those that have been cured and have survived cancer-free for more than 5 years, such as skin basal-cell carcinoma, cervical carcinoma in situ, and papillary thyroid cancer) .
6. Uncontrollable clinical symptom or disease of the heart;
7. Within 14 days before the administration of the study drug, subjects who were required to undergo systemic therapy with corticosteroid (> 10 mg daily prednisone efficacy dose) or other immunosuppressive agents, in the absence of active autoimmune disease, adrenal hormone replacement with inhaled or topical steroids and a therapeutic dose of prednisone > 10 mg/day was allowed;
8. Active infection requiring treatment;
9. Patients with congenital or acquired immunodeficiency(such as HIV),active hepatitis B (HBV-DNA ≥104 copies/ml or 2000 IU/ml) , or hepatitis C (HCV-RNA was above the lower limit of detection);
10. The patient has received other cancer specialised treatment;
11. The live vaccine was administered within 4 weeks before starting the study;
12. Known history of psychotropic substance abuse, alcohol or drug abuse;
13. Pregnant or lactating female;
14. The researchers determined that the subjects had other factors that could have led them to stop the study mid-course, such as having a serious medical condition (including mental illness) that required combined treatment, and severe abnormalities in laboratory tests, family or social factors that may affect the safety of the subject or the collection of experimental data;
15. A patient who is considered by the surgeon to be inoperable;
16. Active tuberculosis;
17. Severe infections (including, but not limited to, hospitalizations for infections, bacteremia, or complications of severe pneumonia) occurring within 4 weeks before study initiation;
18. Received systemic immunostimulatory medication (including but not limited to interferon or interleukin-2[ IL-2]) within 4 weeks before initiation of study treatment or remained within 5 drug half-lives (taking the older of the two) .

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: AK112 combined with AP neoadjuvant therapy; Three cycles of AK112 were given before operation every 3 weeks on D 1, D 22 and D 43, while AP regimen was given every 3 weeks on D 1, D 22 and D 43, respectively.

Drug: AK112; The patients are given AK112 combined with AP regimen every 3 weeks for 3 cycles before operation.; After the neoadjuvant therapy ,the patients will be assessed and be commanded surgery. 3.4-6 weeks after the surgery, the patients will be given chemoradiotherapy or radiotherapy alone decided on the conditon after surgery. 4.The participants will receive AK112 for 14 cycles after surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
EFS	The time between the onset of treatment till disease progression, discontinuation of treatment for any reason, or death	2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
pCR	The percentage of tumor tissue that has completely disappeared on pathological examination after treatment	3 cycles of treatment(1.5months)
OS	The time between the onset of treatment till death	2 years
MPR	The percentage of active tumor components decreasing below a certain threshold	3 cycles of treatment(1.5months)

Collaborators and Investigators

• Sponsor: Wuhan Union Hospital, China

Study record dates

Study Major Dates

• Study Start (Estimated): August 1, 2024
• Primary Completion (Estimated): July 15, 2027
• Study Completion (Estimated): July 30, 2028

Study Registration Dates

• First Submitted: July 31, 2024
• First Submitted That Met QC Criteria: July 31, 2024
• First Posted (Actual): August 5, 2024

Study Record Updates

• Last Update Posted (Actual): August 6, 2024
• Last Update Submitted That Met QC Criteria: August 4, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Keywords: neoadjuvant therapy,AK112,advanced head and neck squamous cell carcinoma
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Neoplasms, Glandular and Epithelial; Head and Neck Neoplasms; Neoplasms, Squamous Cell; Carcinoma; Carcinoma, Squamous Cell; Squamous Cell Carcinoma of Head and Neck
• Other Study ID Numbers: AK112-II-020

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No