National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry (RENOMICA-Hcor)

May 4, 2026 updated by: Hospital do Coracao

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are:

Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

1211

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Brazil
    • Acre
      • Rio Branco, Acre, Brazil, 69915-030
        • Recruiting
        • Centro de Pesquisa Silvestre Santé
        • Contact:
        • Principal Investigator:
          • Odilson Marcos Silvestre
    • Alagoas
      • Maceió, Alagoas, Brazil, 57051-160
        • Recruiting
        • Centro de Pesquisas Clínicas Dr. Marco Mota
        • Principal Investigator:
          • Marco Antonio Mota Gomes
        • Contact:
    • Amapá
      • Macapá, Amapá, Brazil, 68903-419
        • Recruiting
        • Hospital Universitário da Unifap
        • Contact:
        • Principal Investigator:
          • Álan B. F. Rebelo
    • Ceará
      • Fortaleza, Ceará, Brazil, 60840-285
        • Recruiting
        • Hospital de Messejana Dr. Carlos Alberto Studart Gomes
        • Contact:
        • Principal Investigator:
          • Sônia Maria Cavalcante da Rocha
    • Espírito Santo
      • Vila Velha, Espírito Santo, Brazil, 29118-060
        • Recruiting
        • Hospital Evangélico de Vila Velha
        • Contact:
        • Principal Investigator:
          • Carina Laranja Mattos Barreto
    • Estado de Bahia
      • Salvador, Estado de Bahia, Brazil, 40110-060
        • Recruiting
        • Hospital Universitário Professor Edgard Santos
        • Contact:
        • Principal Investigator:
          • Luiz Pereira de Magalhães
      • Salvador, Estado de Bahia, Brazil, 40320-010
        • Recruiting
        • Hospital Ana Nery - HAN/SESAB
        • Contact:
        • Principal Investigator:
          • Mauricio Alves Barreto
    • Federal District
      • Brasília, Federal District, Brazil, 70675-731
        • Recruiting
        • Instituto de Cardiologia e Transplantes do Distrito Federal
        • Contact:
        • Principal Investigator:
          • Cristina Machado Camargo Afiune
    • Goiás
      • Goiânia, Goiás, Brazil, 74605-050
        • Recruiting
        • Hospital das Clínicas da Universidade Federal de Goiás - HC-UFG
        • Contact:
        • Principal Investigator:
          • Weimar Kunz Sebba Barroso de Souza
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30110-934
        • Recruiting
        • Hospital Felicio Rocho - HFR
        • Contact:
        • Principal Investigator:
          • Maria da Consolação Vieira Moreira
      • Belo Horizonte, Minas Gerais, Brazil, 30130-110
        • Recruiting
        • Liga Mineira de Ressuscitação Cardiopulmonar
        • Contact:
        • Principal Investigator:
          • Eduardo Back Stenick
      • Montes Claros, Minas Gerais, Brazil, 39401-001
        • Recruiting
        • Santa Casa de Misericórdia de Montes Claros
        • Contact:
        • Principal Investigator:
          • Luciano Freitas Fernandes
    • Pará
      • Belém, Pará, Brazil, 66093-055
        • Recruiting
        • Health & Care
        • Contact:
        • Principal Investigator:
          • Jonathan S. Sarraf
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, Brazil, 59012-300
        • Recruiting
        • Hospital Universitário Onofre Lopes - UFRN
        • Contact:
        • Principal Investigator:
          • Rosiane Viana Zuza Diniz
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Recruiting
        • Hospital das Clínicas de Porto Alegre - UFRGS
        • Contact:
        • Principal Investigator:
          • Fabiano de Oliveira Poswar
      • Porto Alegre, Rio Grande do Sul, Brazil, 90040-370
        • Recruiting
        • Instituto de Cardiologia - Fundação Universitária de Cardiologia de Porto Alegre - IC-FUC
        • Contact:
        • Principal Investigator:
          • Maico Furlanetto
    • Rio de Janeiro
      • Rio de Janeiro, Rio de Janeiro, Brazil, 20551-030
        • Recruiting
        • Hospital Universitario Pedro Ernesto - UERJ
        • Contact:
        • Principal Investigator:
          • Marcelo Imbroinise Bittencourt
      • Rio de Janeiro, Rio de Janeiro, Brazil, 21941-912
        • Recruiting
        • Instituto de Puericultura e Pediatria Martagão Gesteira
        • Contact:
        • Principal Investigator:
          • Nathalie J. M. Bravo Valenzuela
      • Rio de Janeiro, Rio de Janeiro, Brazil, 21941-913
        • Recruiting
        • Hospital Universitário Clementino Fraga Filho - UFRJ
        • Contact:
        • Principal Investigator:
          • Tais Hanae Kasai Brunswick
      • Rio de Janeiro, Rio de Janeiro, Brazil, 22240-006
        • Recruiting
        • Instituto Nacional de Cardiologia
        • Contact:
        • Principal Investigator:
          • Helena Cramer Veiga Rey
    • Rondônia
      • Porto Velho, Rondônia, Brazil, 76801-098
        • Recruiting
        • Instituto de Pesquisa e Ensino em Saúde - IPES
        • Contact:
          • Mariana Pinheiro Alves Vasconcelos
          • Phone Number: +5569993787257
          • Email: dbpfall@gmail.com
        • Principal Investigator:
          • Mariana Pinheiro Alves Vasconcelos
    • Santa Catarina
      • Joinville, Santa Catarina, Brazil, 89204-250
        • Recruiting
        • Centro Multidisciplinar de Ensino Especializado e Pesquisa Ltda
        • Contact:
        • Principal Investigator:
          • Kárila Scarduelli Luciano
    • São Paulo
      • Bragança Paulista, São Paulo, Brazil, 12916-542
        • Recruiting
        • Hospital Universitário São Francisco na Providência de Deus, USF-SP
        • Contact:
        • Principal Investigator:
          • Murillo O. Antunes
      • Consolação, São Paulo, Brazil, 01228-200
        • Recruiting
        • Instituto PENSI
        • Contact:
        • Principal Investigator:
          • Mauro Fisberg
      • São Carlos, São Paulo, Brazil, 13566-448
        • Recruiting
        • Hospital Universitário da Universidade Federal de São Carlos
        • Contact:
        • Principal Investigator:
          • Meliza Roscani
      • São Paulo, São Paulo, Brazil, 04004-030
        • Recruiting
        • Hospital do Coracao
        • Contact:
        • Principal Investigator:
          • Otavio Eboli
    • Tocantins
      • Palmas, Tocantins, Brazil, 77001-090
        • Recruiting
        • Universidade Federal do Tocantins
        • Contact:
        • Principal Investigator:
          • Luciana Carla Holzbach

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients under routine medical care in hospitals and clinics located in Brazil with a clinical diagnosis of an hereditary cardiovascular disease.

Description

Inclusion Criteria:

  • Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
  • Agree to receive genetic counseling
  • Sign informed consent form
  • Provide the information required in the case report form

Exclusion Criteria:

  • Signature absent from informed consent form
  • Inadequate buccal swab (sample may be collected twice)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Diagnostic yield
Time Frame: 30 months after study start date
Percentage of participants with pathogenic or likely pathogenic variants
30 months after study start date
Genetic diversity
Time Frame: 30 months after study start date
Determine genes that cause hereditary cardiovascular diseases in Brazil
30 months after study start date
Variant frequency
Time Frame: 30 months after study start date
Determine the frequency of disease-causing and benign variants in the Brazilian population
30 months after study start date

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospital do Coracao

Collaborators

Universidade Federal do Rio de Janeiro
Instituto Nacional de Cardiologia de Laranjeiras

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 30, 2025

Primary Completion (Estimated)

August 31, 2026

Study Completion (Estimated)

August 31, 2026

Study Registration Dates

First Submitted

August 6, 2024

First Submitted That Met QC Criteria

August 6, 2024

First Posted (Actual)

August 9, 2024

Study Record Updates

Last Update Posted (Actual)

May 8, 2026

Last Update Submitted That Met QC Criteria

May 4, 2026

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RENOMICA-Hcor

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Genomic data are sensitve and will not be shared for individual participants

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Cardiomyopathy, Dilated

Clinical Trials on whole genome sequencing

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Bulgaria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe