Chemical and Microbiological Exposure of Women on Dairy Cattle Farms (DAISY-Expo)

Expositions Chimique et Microbiologique Des Femmes Dans Les Exploitations Bovines laitières

Although professionals working on dairy cattle farms come into contact with a wide range of chemicals and microbiological agents, little is known about this possible exposure, which occurs a priori via inhalation and skin contact.

The aim of this research is to gain a better understanding of this chemical and microbiological exposure, and this research focuses in particular on professional women working on dairy cattle farms , who may be in charge of specific activities not commonly carried out by professional men.

Exposure to pesticides, antiparasitic products and disinfectants will be the first substances to be investigated, followed by other chemical or particulate compounds present in everyday and professional environments. Exposure to these compounds will be measured by their presence in the urine, feces (if possible) and hair of around 60 participating women, as well as in bovine tuft/head hair and, if possible, air samples taken in milking buildings.

Study Overview

• Status: Active, not recruiting
• Conditions: Occupational Exposure to Chemicals

• Study Type: Observational
• Enrollment (Estimated): 80

Contacts and Locations

Study Locations

• France
  • Rennes, France, 35000
    • UMR1085 Irset

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Adult women working on dairy cattle farms in West area of France

Description

Inclusion Criteria:

• Adult woman working on a dairy cattle farm in the "Grand Ouest" region of France
• Woman who speaks and understands French

Exclusion Criteria:

• working less than 20h/week in dairy farms
• Woman under legal protection
• unsigned consent form

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exposure to chemicals of women working on dairy farms	Concentrations of pesticide molecules, biocides, disinfectants and microbiological agents, measured in; urines of professional women working on dairy farms,; the hair of professional women working on dairy farms,; faeces of professional women from dairy farms,; tuft/head hair from females in the herd on farms where female professionals work,; environmental samples of pesticide molecules (PPPs, pesticides), biocides, disinfectants and microbiological agents.	At inclusion and at the end of the follow-up (for hair-concentrations), and during specific periods of agricultural activities (with two 4-day periods of urine sample collection, one period of faeces collection, and one week of environmental sampling)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exposure to other chemicals	Concentrations measured in urine, hair, feces, toupillon/head hair and environmental samples from the farm of other chemical compounds present in the participants' professional uses and environments.	At inclusion and at the end of the follow-up (for hair-concentrations), and during specific periods of agricultural activities (with two 4-day periods of urine sample collection, one period of faeces collection, and one week of environmental sampling)

Collaborators and Investigators

• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
• Collaborators: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Ecole des Hautes Etudes en Santé Publique
• Investigators: Principal Investigator: Cecile Chevrier, Inserm UMR1085 Irset

Study record dates

Study Major Dates

• Study Start (Actual): January 3, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): January 1, 2028

Study Registration Dates

• First Submitted: November 14, 2024
• First Submitted That Met QC Criteria: November 25, 2024
• First Posted (Actual): November 29, 2024

Study Record Updates

• Last Update Posted (Actual): March 9, 2026
• Last Update Submitted That Met QC Criteria: March 6, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: women; pesticides; occupational exposure; farmer; chemicals; biocides
• Other Study ID Numbers: C23-69; 2024-A00966-41 (Registry Identifier: ID RCB)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: No or required a additional/new ethic authorization

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No