Role of Multi-detector CT and MRI in Diagnosis of Congenital Inner Ear Anomalies

Evaluation of combined value of Multi-detector computed tomography (MDCT) and Magnetic resonance imaging (MRI) in the diagnosis of congenital abnormalities of the inner ear and internal auditory canal in patients with congenital hearing loss and preoperative evaluation of cochlear implant candidates.

Study Overview

• Status: Not yet recruiting
• Conditions: Ear Disease, Inner
• Intervention / Treatment: Device: MRI ,ct

Detailed Description

Introduction:

Inner ear malformation (IEM) with associated sensoryneural hearing loss (SNHL) is a major cause of childhood disability.

The embryology of the inner ear must be known as many of the inner ear malformations present as a result of the arrest during the various stages of embryology.

Congenital malformations of the inner ear may be considered in two broad categories:

1. malformations with pathologic changes that involve only the membranous labyrinth.
2. malformations that involve both the osseous and the membranous labyrinth.

Congenital sensorineural hearing loss arises as a result of abnormalities in the inner ear, the vestibulocochlear nerve, or the processing centres of the brain. The abnormality may have a genetic cause or be a sequel of infection or injury at birth; in some cases, no cause is identified.

One of the paths in the investigation of congenital sensorineural hearing loss (CSNHL) is to try to characterize its aetiology through the inner ear evaluation using high resolution computer tomography (CT) scans. With minor malformation, it is not always possible for a simple visual inspection to recognize if the structure in the inner ear is normal or not.

Both CT and MR can be used to look at inner ear malformations but often both techniques are complementary. CT is preferred when associated middle or external ear malformations must be excluded. Magnetic resonance is preferred when subtle changes in the membranous labyrinth or abnormalities of the nerves in the internal auditory canal must be visualised Moreover, some changes inside the membranous labyrinth can only be seen on sub-millimetric heavily T2-weighted MR images.

Only MR can demonstrate the abnormal course, hypoplasia or aplasia of the vestibulocochlear nerve (or one of is three branches) and facial nerve.

HRCT and MRI temporal bone are complementary to each other in evaluating children for cochlear implantation as HRCT is excellent for demonstrating bony details but, lack in providing details of inner ear neural structures and MRI is better than CT in demonstrating vestibulocochlear nerves.

Combined HRCT and MRI studies are mandatory for evaluation of inner ear, the radiologist must be familiar with imaging findings that absolutely contraindicate implantation (Cochlear aplasia, cochlear nerve aplasia and labyrinthine aplasia), and with those that relatively contraindicate implantation (labyrinthitis ossificans, other inner ear dysplasia) and with other findings that could significantly alter or complicate surgery (hypo plastic mastoid process, facial nerve dehiscence, oto-mastoiditis)

• Study Type: Observational
• Enrollment (Estimated): 26

Contacts and Locations

• Study Contact: Name: Sarah K Fahmi; Phone Number: +01017507865 +201554577818; Email: Khaledsarah155@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Any age group come for cochlear implantation

Description

Inclusion Criteria:

• all patient of inner ear anomalies

Exclusion Criteria:

• studied groups ,mri

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Inner ear anomalies detection by CT and MRI	accurate and early diagnosis of patsuffer from suffer from sensory neural hearing loss (SNHL)	Baseline

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Study Director: Yasser Y. Mohamed, Assistant professor doctor; Study Director: Hossam E. Mohamed, PROFESSOR DOCTOR

Study record dates

Study Major Dates

• Study Start (Estimated): December 20, 2024
• Primary Completion (Estimated): December 20, 2026
• Study Completion (Estimated): December 20, 2027

Study Registration Dates

• First Submitted: November 22, 2024
• First Submitted That Met QC Criteria: November 26, 2024
• First Posted (Estimated): December 2, 2024

Study Record Updates

• Last Update Posted (Estimated): December 2, 2024
• Last Update Submitted That Met QC Criteria: November 26, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Keywords: MRI; Ct; Ear disease
• Additional Relevant MeSH Terms: Otorhinolaryngologic Diseases; Otitis; Labyrinth Diseases; Labyrinthitis; Ear Diseases
• Other Study ID Numbers: CT,MRI in inner ear anomalies

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No