A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING (UP-RISING)

February 12, 2026 updated by: AbbVie

Comparison of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care

This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany.

Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

678

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Germany
      • Bad Pyrmont, Germany, 31812
        • Completed
        • MVZ Weserbergland /ID# 276009
      • Berlin, Germany, 13055
        • Recruiting
        • Private Practice - Dr. Silke Zinke /ID# 276366
      • Braunschweig, Germany, 38114
        • Recruiting
        • MVZ Herzogin Elisabeth Hospital /ID# 272725
      • Coburg, Germany, 96450
        • Recruiting
        • Private Practice - Dr. Sebastian Schuh /ID# 272731
      • Düren, Germany, 52355
        • Recruiting
        • Rheumapraxis Düren /ID# 272726
      • Ehringshausen, Germany, 35630
        • Recruiting
        • Praxis Dilltal /ID# 272727
      • Erfurt, Germany, 99096
        • Recruiting
        • Private Practice - Dr. Daniel Bestler /ID# 272741
      • Greifswald, Germany, 17493
        • Recruiting
        • Praxis Fiene /ID# 279410
      • Hamburg, Germany, 22391
        • Recruiting
        • Private Practice - Dr. Hauke E. Heintz /ID# 278081
      • Naumburg, Germany, 06618
        • Recruiting
        • Rheumatologische Facharztpraxis /ID# 272743
      • Waren, Germany, 17192
        • Recruiting
        • Praxis F. Schattenberg /ID# 280322
      • Wuppertal, Germany, 42105
        • Recruiting
        • Cellitinnen-Krankenhaus St. Josef /ID# 275926
      • Wuppertal, Germany, 42285
        • Recruiting
        • Praxis Barmen /ID# 277514
    • Baden-Wurttemberg
      • Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79098
        • Recruiting
        • Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584
      • Heidelberg, Baden-Wurttemberg, Germany, 69120
        • Recruiting
        • Rheumapraxis Heidelberg /ID# 276475
      • Tübingen, Baden-Wurttemberg, Germany, 72072
        • Recruiting
        • Rheumapraxis Haas Tübingen /ID# 275536
      • Ulm, Baden-Wurttemberg, Germany, 89073
        • Recruiting
        • Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293
    • Bavaria
      • Amberg, Bavaria, Germany, 92224
        • Recruiting
        • Dr. Med. Thomas Marycz /ID# 274646
      • Augsburg, Bavaria, Germany, 86157
        • Recruiting
        • Rheumapraxis Am Webereck /ID# 274412
      • Marktredwitz, Bavaria, Germany, 95615
        • Recruiting
        • Dr. Harmuth /ID# 273401
      • Munich, Bavaria, Germany, 81541
        • Recruiting
        • Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138
      • Planegg, Bavaria, Germany, 82152
        • Recruiting
        • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587
    • Brandenburg
      • Hohen Neuendorf, Brandenburg, Germany, 16540
        • Recruiting
        • Private Practice - Dr. Dirk Wernicke /ID# 276820
      • Hoppegarten, Brandenburg, Germany, 15366
        • Recruiting
        • Praxis K. Pagel /ID# 279121
      • Potsdam, Brandenburg, Germany, 14467
        • Recruiting
        • Rheumahaus Studien GbR /ID# 275917
      • Templin, Brandenburg, Germany, 17268
        • Recruiting
        • Rheumatologisch Immunologisch /ID# 275830
    • Hesse
      • Bad Endenbach, Hesse, Germany, 35080
        • Recruiting
        • Rheumatism Center Mittelhessen /ID# 274641
      • Frankfurt am Main, Hesse, Germany, 60329
        • Recruiting
        • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30161
        • Recruiting
        • Rheumapraxis Hannover-List /ID# 273735
      • Hanover, Lower Saxony, Germany, 30173
        • Recruiting
        • Praxis. F. Bigdeli-Wilshusen /ID# 273455
      • Kassel, Lower Saxony, Germany, 34125
        • Recruiting
        • Rheumatologie Kassel /ID# 275916
      • Osnabrück, Lower Saxony, Germany, 49074
        • Recruiting
        • Rheumapraxis An Der Hase /ID# 276949
      • Weyhe, Lower Saxony, Germany, 28844
        • Recruiting
        • Fachpraxis für Rheumatologie und Osteologie /ID# 275359
    • Mecklenburg-Vorpommern
      • Neubrandenburg, Mecklenburg-Vorpommern, Germany, 17033
        • Recruiting
        • Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367
    • North Rhine-Westphalia
      • Herne, North Rhine-Westphalia, Germany, 44649
        • Recruiting
        • Rheumazentrum Ruhrgebiet /ID# 275518
      • Meerbusch, North Rhine-Westphalia, Germany, 40668
        • Recruiting
        • St.Elisabeth Hospital Meerbusch /ID# 275030
      • Ratingen, North Rhine-Westphalia, Germany, 40882
        • Recruiting
        • Rheumazentrum Ratingen /ID# 275707
    • Rhineland-Palatinate
      • Kaiserslautern, Rhineland-Palatinate, Germany, 67657
        • Recruiting
        • Praxis Dr. med. Florian Beyer /ID# 274293
    • Saarland
      • Homburg, Saarland, Germany, 66424
        • Recruiting
        • Rheumapraxis am Schlossberg /ID# 272728
      • Neunkirchen, Saarland, Germany, 66538
        • Recruiting
        • Dr. Murawski /ID# 272724
      • Püttlingen, Saarland, Germany, 66346
        • Recruiting
        • Knappschaftsklinikum Saar /ID# 279852
      • Püttlingen, Saarland, Germany, 66346
        • Recruiting
        • Rheumapraxis Dr. Prothmann /ID# 279851
    • Saxony
      • Chemnitz, Saxony, Germany, 09130
        • Recruiting
        • Medizinischen Versorgungszentrums Agilomed /ID# 274887
      • Freiberg, Saxony, Germany, 09599
        • Recruiting
        • Dr. Mueller /ID# 273081
      • Leipzig, Saxony, Germany, 04109
        • Recruiting
        • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358
      • Leipzig, Saxony, Germany, 04129
        • Recruiting
        • Private Practice - Dr. Ilka Schwarze /ID# 276981
      • Plauen, Saxony, Germany, 08523
        • Recruiting
        • Private Practice - Dr. Christine Baumann /ID# 275095
      • Zwickau, Saxony, Germany, 08056
        • Recruiting
        • Praxis H. Fricke-Wagner /ID# 274467
    • Saxony-Anhalt
      • Halle, Saxony-Anhalt, Germany, 06128
        • Recruiting
        • Rheumapraxis Dr. Liebhaber /ID# 274888
      • Magdeburg, Saxony-Anhalt, Germany, 39104
        • Recruiting
        • Rheumatologische Facharztpraxis /ID# 272866
    • Schleswig-Holstein
      • Rendsburg, Schleswig-Holstein, Germany, 24768
        • Recruiting
        • Private Practice - Dr. Jochen Walter /ID# 280069
    • Thuringia
      • Altenburg, Thuringia, Germany, 04600
        • Recruiting
        • Private Practice - Dr. Thomas Kupka /ID# 273631
      • Weimar, Thuringia, Germany, 99427
        • Recruiting
        • Rheumapraxis Weimar /ID# 272740

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Participants with moderate to severe active Rheumatoid Arthritis receiving Upadcitinib or a Tumor necrosis factor inhibitor treatment.

Description

Inclusion Criteria:

  • Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
  • Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
  • UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies

Exclusion Criteria:

  • Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug [whichever is longer] prior to baseline)
  • Prior treatment with Upadacitinib
  • Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Upadacitinib
Participants will receive upadacitinib as prescribed by their physician according to local label.
Tumor Necrosis Factor Inhibitor-Treatment
Participants will receive a tumor necrosis factor inhibitor treatment as prescribed by their physician according to local label.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Retention Rate of UPA vs TNFi
Time Frame: Up to approximately 24 months
Time to the discontinuation of Upadacitinib. Time to the discontinuation of Tumor Necrosis Factor Inhibitor treatment
Up to approximately 24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AbbVie

Investigators

  • Study Director: ABBVIE INC., AbbVie

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 7, 2024

Primary Completion (Estimated)

December 1, 2028

Study Completion (Estimated)

December 1, 2028

Study Registration Dates

First Submitted

November 27, 2024

First Submitted That Met QC Criteria

November 27, 2024

First Posted (Actual)

December 2, 2024

Study Record Updates

Last Update Posted (Actual)

February 17, 2026

Last Update Submitted That Met QC Criteria

February 12, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P25-188

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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