Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis

February 12, 2025 updated by: Hasan Basri Savas, Mardin Artuklu University
Modes of delivery impact maternal oxidative stress biomarkers and dynamic thiol disulphide homeostasis

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

58

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Antalya, Turkey
        • Alanya Training and Research Hospital Gynecology and Obstetrics Department

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Pregnant women

Description

Inclusion Criteria:

For VD group:

  • Women with spontaneous uncomplicated vaginal delivery
  • Women who were in the 38th week and vertex presentation and whose contractions had started naturally.

For CS group:

• Women in their 38th week of pregnancy who delivered by elective CS without uterine contractions

Exclusion Criteria:

  • Participants who were smokers
  • Participants who had a non-optimal pre-pregnancy body mass index
  • Systemic diseases such as diabetes mellitus and gestational hypertension.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
vaginal delivery
35 women who had spontaneous vaginal deliveries
cesarean section
23 women who had elective cesarean sections without labor

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Total antioxidation state (μmol Trolox equivalent/ L),
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Total oxidation status(μmol H2O2 equivalent/L)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Oxidative stress index (arbitrary unit)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Disulfide (-S-S-) (µmol / L) / alb (g / l)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Total thiol (µmol / L)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Native thiol (µmol / L) / alb (g / l)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Ischemia modified albumin (U/L)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Paroxanase (U/L)
From January 2021 to August 2021
Oxidative stress markers
Time Frame: From January 2021 to August 2021
Arylesterase (Ku/l)
From January 2021 to August 2021

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mardin Artuklu University

Collaborators

Alanya Alaaddin Keykubat University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 3, 2021

Primary Completion (Actual)

August 30, 2021

Study Completion (Actual)

December 1, 2021

Study Registration Dates

First Submitted

February 7, 2025

First Submitted That Met QC Criteria

February 12, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 12, 2025

Last Verified

January 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • 18.09.2020 / 23-9

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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