Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients

Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients Using the 6-Minute Walk Test

The purpose of this study is to compare the time required to reach an end-tidal oxygen (EtO2) value of 90% and the time until the Oxygen Reserve Index (ORI) drops below 0.55 during preoxygenation in sarcopenic and non-sarcopenic patients. The study aims to investigate the impact of sarcopenia on the oxygenation process.

Study Overview

• Status: Not yet recruiting
• Conditions: Sarcopenia; Preoxygenation; Oxygen Reserve Index
• Intervention / Treatment: Diagnostic test: preoxygenation

• Study Type: Observational
• Enrollment (Estimated): 80

Contacts and Locations

• Study Contact: Name: Betül Güven Aytaç, Assoc.prof.; Phone Number: +905073578351; Email: drbguven@hotmail.com

Study Locations

• Turkey
  • Ankara, Turkey
    • Ankara City Hospital Bilkent

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

80 patients who agreed to participate in the study and are scheduled for major abdominal oncological surgery will be included in the study.

Description

Inclusion Criteria:

• Patients who agree to participate in the study.
• Patients scheduled for major abdominal oncologic surgery.

Exclusion Criteria:

• Patients with severe cardiopulmonary disease.
• Patients with walking disabilities.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
sarcopenic; sarcopenia based on the 6-minute walk test results.	Diagnostic test: preoxygenation; The time required to reach EtO2 90% and the time until ORI drops below 0.55
non-sarcopenic; non-sarcopenia based on the 6-minute walk test results.	Diagnostic test: preoxygenation; The time required to reach EtO2 90% and the time until ORI drops below 0.55

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Time required to reach EtO2 90%	preoperatively
Time until ORI drops below 0.55	preoperatively

Collaborators and Investigators

• Sponsor: Ankara City Hospital Bilkent

Study record dates

Study Major Dates

• Study Start (Estimated): March 1, 2025
• Primary Completion (Estimated): May 30, 2025
• Study Completion (Estimated): August 31, 2025

Study Registration Dates

• First Submitted: February 18, 2025
• First Submitted That Met QC Criteria: February 21, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 21, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neurologic Manifestations; Nervous System Diseases; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Sarcopenia
• Other Study ID Numbers: TABED1-25-884

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No