Proton Pump Inhibitor Use and Dental Implant Success

February 23, 2025 updated by: Berkay Tokuç

Evaluation of the Relationship Between Proton Pump Inhibitor Use and Dental Implant Success: a Retrospective Study

The goal of this observational study is to evaluate the effects of proton pump inhibitors (PPIs) on the surrounding bone and the survival of dental implants. The main questions it aims to answer are:

Does PPI use affect the survival rate of dental implants? Does PPI use influence crestal bone loss and fractal dimension (FD) of the surrounding bone?

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

54

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Kocaeli, Turkey, 41040
        • Kocaeli University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

The study was conducted with patients who had a history of PPI use for more than six months and systemically healthy individuals who had undergone regular clinical and radiological follow-ups after dental implant placement at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University.

Description

Inclusion Criteria:

  • Being over 18 years old,
  • Having a history of PPI use for more than six months,
  • Having at least one bone-level and axially placed dental implant in the maxilla or mandible,
  • Having a minimum of one year elapsed since the prosthetic restoration following dental implant placement,
  • Having undergone routine clinical follow-ups and radiological evaluations with periapical radiographs taken using the parallel cone technique after dental implant placement.

Exclusion Criteria:

  • Individuals with a history of PPI use for less than six months,
  • Individuals with periapical radiographs of low image quality or with artifacts,
  • Individuals for whom the regions selected for fractal analysis on periapical radiographs are not appropriately sized,
  • Individuals who have not undergone routine clinical and radiographic follow-ups.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Fractal Dimension Value
Time Frame: Fractal analysis values were calculated on radiographs within 1 month after the data collection of the patients.
Fractal analysis values were calculated on radiographs within 1 month after the data collection of the patients.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Berkay Tokuç

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2023

Primary Completion (Actual)

April 15, 2024

Study Completion (Actual)

May 15, 2024

Study Registration Dates

First Submitted

February 23, 2025

First Submitted That Met QC Criteria

February 23, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 23, 2025

Last Verified

February 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • 2023/295

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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