Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood encephalopathy and a follow-up tracking question and answer system for childhood encephalopathy patients.

Study Overview

• Status: Recruiting
• Conditions: Cerebral Palsy; Attention Deficit Hyperactivity Disorder; Mental Retardation; Tourette's Syndrome; Autism Spectrum Disorders
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Estimated): 2000

Contacts and Locations

• Study Contact: Name: Yun Liu PhD; Phone Number: +86 13023876996; Email: 20200413@njucm.edu.cn

Study Locations

• China
  • Nanjing, China
    • Recruiting
    • Jiangsu Provincial Hospital of Traditional Chinese Medicine
    • Contact: Dong Chen Dr.; Phone Number: +86 134 0587 1656; Email: 648728749@qq.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Childhood encephalopathy

Description

Inclusion Criteria:

• 1. meet diagnostic criteria for CP ID TD ADHD ASD; 2. gender is not limited;

Exclusion Criteria:

• 1. CP ID TD ASD due to chorea hepatomegaly hearing abnormality and pharmacogenetic factors;
• 2. Children with other major mental illnesses (e.g. schizophrenia) or organic diseases (e.g. congenital heart disease);

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Childhood Autism Rating Scale	The total score ranges from 15 to 60, with the higher the score the worse the symptoms are	4 mouths
meridian and acupointological features	After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".	4 mouths
Yale Global Tic Severity Scale	It has a score range of 0-100, with higher scores representing more severe symptoms.	4 mouths
Gross Motor Function Assessment Scale (GMFM)-88	GMFM-88 scores range from 0-264, with higher scores being better.	4 mouths
Autism Behavior Checklist	It has a score range of 0-174, with higher scores representing more severe symptoms.	4 mouths
acupuncture point status	After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".	4 mouths
Tongue texture	After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".	4 mouths
Wechsler intelligence scale (WIS)	FIQ = 100: Indicates that the individual has an average level of intelligence. FIQ > 100: Indicates an above average level of intelligence. FIQ < 100: Indicates a below average level of intelligence.	4 mouths
Resting heart rate		4 mouths
blood pressure (systolic, diastolic) after 10 minutes of rest		4 mouths
Conners Rating Scales	Scores are converted to standardized T-scores for comparison with the mean of the peer group. T-scores above 65 are usually considered clinically significant.	4 mouths
tongue coating, pulse	After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".	4 mouths
respiratory rate		4 mouths
Body temperature		4 mouths

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Saliva	Destruction after use. Metabolomics after sample collection.	4 mouths
blood	Destruction after use. Metabolomics after sample collection.	4 mouths
Urine	Destruction after use. Metabolomics after sample collection.	4 mouths
Faeces	Destruction after use. Metabolomics after sample collection.	4 mouths

Collaborators and Investigators

• Sponsor: Yun Liu,PhD

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2024
• Primary Completion (Estimated): February 28, 2025
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: February 18, 2025
• First Submitted That Met QC Criteria: February 22, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 22, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neurologic Manifestations; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Mental Disorders; Neurobehavioral Manifestations; Neurodevelopmental Disorders; Child Development Disorders, Pervasive; Brain Damage, Chronic; Attention Deficit and Disruptive Behavior Disorders; Autism Spectrum Disorder; Cerebral Palsy; Intellectual Disability; Attention Deficit Disorder with Hyperactivity
• Other Study ID Numbers: HospitalNanjingU; Nanjing Science and Technology (Other Identifier: HospitalNanjingU)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED