Translational Research GRICS-CineCardiac

April 20, 2026 updated by: Institut National de la Santé Et de la Recherche Médicale, France

Imagerie Cardiaque Ciné Par résonance magnétique en Respiration Libre

This project is a pilot study which aims at showing the feasibility of free breathing cardiac MRI using GRICS (Generalized Reconstruction by Inversion of Coupled System)software in a clinical environment.

The GRICS technique has been developed by the IADI (Diagnostic, Adaptive and Interventional Imaging)lab, Nancy, France. It enables free breathing MRI thanks to a reconstruction algorithm which provides artefact-free images based on raw MR data and physiological data from external sensors (respiratory belts, ECG.

In this study, we want to acquire free breathing cardiac cine images during a standard cardiac MR exam and compare those data with the breath-hold ones.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Vandœuvre-lès-Nancy, France, 54511
        • CHU Brabois

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • candidate to cardiac MR exam because of ischemic or dilated cardiopathy
  • legally an adult
  • having heath insurance
  • having signed the consent form

Exclusion Criteria:

  • dyspnea
  • atrial fibrillation
  • pain while lying on the back for a long time
  • inability to follow a procedure
  • contraindication to MRI
  • contraindication to gadolinium chelate injection

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Patients
Device: Additional free breathing MR acquisitions

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Qualitative image reading by the radiologist
Time Frame: 1 Month
Feasibility of GRICS CardioCine : the radiologist responds to a questionnaire
1 Month
Quantitative image analysis by the radiologist
Time Frame: 1 Month
Feasibility of GRICS CardioCine : the radiologist responds to a questionnaire
1 Month

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Right ventricular end-diastolic volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Left ventricular end-diastolic volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Right ventricular end-systolic volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Left ventricular end-systolic volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Right ventricular systolic ejection volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Left ventricular systolic ejection volume
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Right ventricular ejection fractions
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Left ventricular ejection fractions
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Left ventricular mass in diastole
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Aortic flow
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1
Analysis of the segmental kinetics of the left ventricle
Time Frame: Day 1
Free-breathing and breath-hold measurements
Day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2011

Primary Completion (Actual)

October 1, 2012

Study Completion (Actual)

October 1, 2012

Study Registration Dates

First Submitted

February 21, 2013

First Submitted That Met QC Criteria

March 10, 2025

First Posted (Actual)

March 17, 2025

Study Record Updates

Last Update Posted (Actual)

April 23, 2026

Last Update Submitted That Met QC Criteria

April 20, 2026

Last Verified

March 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • C10-04
  • 2010-A00789-30 (Registry Identifier: IDRCB)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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