Evaluation Of Effect of Axial Length on Cup-To-Disc Ratio Among Non- Glaucomatous Hypertensive Patients

This observational cross-sectional study aims to compare the effect of axial length on the cup-to-disc ratio in non-glaucomatous hypertensive patients. Data will be collected from Khursheed Begum Eye Hospital and LRBT Hospital, with a sample size of 104 participants. A purposive sampling technique will be used.

Study Overview

• Status: Active, not recruiting
• Conditions: Hypertensive Complication

Detailed Description

Patients aged 18-70 years with systemic hypertension for at least one year and normal intraocular pressure will be included. Exclusion criteria include glaucoma, high myopia, hyperopia, ocular surgery, trauma, and optic nerve diseases. Axial length will be measured using optical biometry or A-scan ultrasonography, while the cup-to-disc ratio will be assessed through fundus examination using a slit lamp biomicroscope with a +90D lens or optical coherence tomography (OCT). Data will be meticulously documented, including patient demographics and medical history. The study will be completed within six months after approval, ensuring accurate and standardized measurements for reliable results.

• Study Type: Observational
• Enrollment (Actual): 94

Contacts and Locations

Study Locations

• Pakistan
  • Punjab
    • Gujrānwāla, Punjab, Pakistan
      • Alshifa eye clinic Ali Pur chattha

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

his observational cross-sectional study aims to compare the effect of axial length on the cup-to-disc ratio in non-glaucomatous hypertensive patients. Data will be collected from Khursheed Begum Eye Hospital and LRBT Hospital

Description

Inclusion Criteria:

• Male and female patients diagnosed with systemic hypertension for at least 1 year.
• Age between 18-70 years.
• Normal intraocular pressure (IOP<-21mmhg)
• Axial length between 21mm and 26mm (to exclude extreme refractive errors)

Exclusion Criteria:

• History of glaucoma or ocular hypertension.
• High myopia (<-6.00 D) or hyperopia (>+6.00D).
• History of ocular surgery, trauma, or retinal diseases.
• Any optic nerve diseases.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Axial length measured by biometry and CD ratio by slitlamp	The axial length, measured in millimeters, is defined as the distance from the anterior surface of the cornea to the retinal pigment epithelium. The axial length can be measured using either ultrasound biometry (accomplished via direct contact or immersion) or optical biometry	12 Months

Collaborators and Investigators

• Sponsor: Superior University

Study record dates

Study Major Dates

• Study Start (Actual): March 20, 2025
• Primary Completion (Estimated): June 20, 2025
• Study Completion (Estimated): February 20, 2026

Study Registration Dates

• First Submitted: March 29, 2025
• First Submitted That Met QC Criteria: March 29, 2025
• First Posted (Actual): April 6, 2025

Study Record Updates

• Last Update Posted (Actual): April 6, 2025
• Last Update Submitted That Met QC Criteria: March 29, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: MSRSW/Batch-Fall23/802

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No