The Effect of Huel on Markers of Inflammation

June 25, 2025 updated by: Anthony Watson, Newcastle University
This project will assess the effect of Huel on markers of gastrointestinal inflammation of 30 generally healthy individuals. The aim is to identify any changes in the markers of inflammation status of volunteers in any of the 9 markers to be monitored. Inflammation status will be measured at the start of the study, after one week of their habitual diets and again after four weeks of consuming two ready to drink Huel products per day, one Hot & Savoury Huel (grain-based option only) and the remainder of their calorie intake to be made up of Huel Powder (v3.1).

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Tyne and wear
      • Newcastle Upon Tyne, Tyne and wear, United Kingdom, NE18ST
        • Faculty of Medical Sciences

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Generally healthy Aged 18 years and over Non-pregnant, Non-lactating non-smoking

Exclusion Criteria:

Smoker Pregnant Lactating BMI >30 Food allergy Disordered eating Disorder which could impact the study outcomes Medications which could impact the study outcomes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 4 weeks consumption of Huel ready to eat foods
Dietary supplement: Huel
Ready to eat huel foods. Containing 2 ready to drink shakes, one savoury meal pack and meal replacement powder. Consumption amounts were based on energy needs of each person

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
C-Reactive protein
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
neutrophils
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
TNF-alpha
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
IL-10
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
IL-6
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation

Secondary Outcome Measures

Outcome Measure
Time Frame
linoleic acid
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
arachidonic acid
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
alpha-linoleic acid
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
eicosapentaenoic acid
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
Body Mass Index
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
Body mass
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation
Waist cercumference
Time Frame: baseline and after 4 weeks supplementation
baseline and after 4 weeks supplementation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Newcastle University

Collaborators

Aelius Biotech

Investigators

  • Principal Investigator: Anthony W Watson, PhD, Newcastle University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2025

Primary Completion (Estimated)

August 1, 2025

Study Completion (Estimated)

August 1, 2025

Study Registration Dates

First Submitted

June 25, 2025

First Submitted That Met QC Criteria

June 25, 2025

First Posted (Actual)

July 3, 2025

Study Record Updates

Last Update Posted (Actual)

July 3, 2025

Last Update Submitted That Met QC Criteria

June 25, 2025

Last Verified

June 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Prot1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

This is not acceptable due to the ethical approval given

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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