Perioperative Blood Transfusion and Increased One-year Mortality

Association of Perioperative Blood Transfusion With Increased One-year Mortality After Surgery: a Retrospective Propensity Score-Matched Cohort Study

The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries. The main question it aims to answer perioperative blood transfusion is associated with increased one-year mortality across various surgical settings. We will retrospectively collect the clinical data (including one-year mortality) in patients with perioperative blood transfusion or not and analysis the association between perioperative blood transfusion and one-year mortality after surgery.

Study Overview

• Status: Completed
• Conditions: Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery
• Intervention / Treatment: Other: perioperative blood transfusion

• Study Type: Observational
• Enrollment (Actual): 97443

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Adult patients who underwent surgery at Singapore General Hospital between 1 January 2012 and 31 October 2016

Description

Inclusion Criteria:

• ≥18 years
• Patients undergoing first-time cardiothoracic surgery, orthopedics, obstetrics and gynecology, general surgery, otolaryngology, hand surgery, neurosurgery, colorectal surgery, urology, plastic surgery, and oral and maxillofacial surgery were included.

Exclusion Criteria:

• Patients with missing values for the American Society of Anesthesiologists (ASA) physical status, revised cardiac risk index (RCRI), degree of preoperative anemia, kidney disease, or race were excluded.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
PBT group; Patients in PBT group received red blood cell concentrate units during surgery and up to one month postoperatively.	Other: perioperative blood transfusion; The PBT group received the red blood cell concentrate units during surgery and up to one month postoperatively.
No-PBT group; Patients in No-PBT group did not receive red blood cell concentrate units during surgery and up to one month postoperatively.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
one-year mortality after surgery	one year after surgery

Collaborators and Investigators

• Sponsor: Changhai Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2012
• Primary Completion (Actual): October 31, 2016
• Study Completion (Actual): October 31, 2016

Study Registration Dates

• First Submitted: July 23, 2025
• First Submitted That Met QC Criteria: July 23, 2025
• First Posted (Actual): July 30, 2025

Study Record Updates

• Last Update Posted (Actual): July 30, 2025
• Last Update Submitted That Met QC Criteria: July 23, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: PBTOM

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No