Perioperative Blood Transfusion and Increased One-year Mortality
July 23, 2025 updated by: Wen-bin Lu, MD, Changhai Hospital
Association of Perioperative Blood Transfusion With Increased One-year Mortality After Surgery: a Retrospective Propensity Score-Matched Cohort Study
The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries.
The main question it aims to answer perioperative blood transfusion is associated with increased one-year mortality across various surgical settings.
We will retrospectively collect the clinical data (including one-year mortality) in patients with perioperative blood transfusion or not and analysis the association between perioperative blood transfusion and one-year mortality after surgery.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
97443
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
N/A
Sampling Method
Non-Probability Sample
Study Population
Adult patients who underwent surgery at Singapore General Hospital between 1 January 2012 and 31 October 2016
Description
Inclusion Criteria:
- ≥18 years
- Patients undergoing first-time cardiothoracic surgery, orthopedics, obstetrics and gynecology, general surgery, otolaryngology, hand surgery, neurosurgery, colorectal surgery, urology, plastic surgery, and oral and maxillofacial surgery were included.
Exclusion Criteria:
- Patients with missing values for the American Society of Anesthesiologists (ASA) physical status, revised cardiac risk index (RCRI), degree of preoperative anemia, kidney disease, or race were excluded.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
PBT group
Patients in PBT group received red blood cell concentrate units during surgery and up to one month postoperatively.
|
The PBT group received the red blood cell concentrate units during surgery and up to one month postoperatively.
|
|
No-PBT group
Patients in No-PBT group did not receive red blood cell concentrate units during surgery and up to one month postoperatively.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
one-year mortality after surgery
Time Frame: one year after surgery
|
one year after surgery
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2012
Primary Completion (Actual)
October 31, 2016
Study Completion (Actual)
October 31, 2016
Study Registration Dates
First Submitted
July 23, 2025
First Submitted That Met QC Criteria
July 23, 2025
First Posted (Actual)
July 30, 2025
Study Record Updates
Last Update Posted (Actual)
July 30, 2025
Last Update Submitted That Met QC Criteria
July 23, 2025
Last Verified
July 1, 2025
More Information
Terms related to this study
Other Study ID Numbers
- PBTOM
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.