Knowledge About the Administration and Regulation of High Alert Medications Among Nurses in Mansoura University Children's Hospital: A Hospital-wide Audit (HAM-Audit)

November 17, 2025 updated by: Omar Hamdy

Pediatric Medication Safety Revolution: Auditing Nurses' Knowledge on High-Alert Drugs

This study checks how well nurses at Mansoura University Children's Hospital know about high-alert medications (HAMs). These are drugs that can cause serious harm if given incorrectly. We used a questionnaire to assess their knowledge and identify any gaps. The goal is to improve training and reduce medication errors in the hospital.

Study Overview

Status

Completed

Conditions

Detailed Description

Background:

Medication errors (MEs) are a major cause of patient harm, especially in pediatric settings. High-alert medications (HAMs) are drugs that carry a heightened risk of causing significant patient harm when used in error. Nurses play a critical role in the safe administration of HAMs. This hospital-wide audit aims to evaluate nurses' knowledge regarding the administration and regulation of HAMs at Mansoura University Children's Hospital.

Objectives:

  1. To assess the level of knowledge about HAMs among nurses.
  2. To identify factors associated with sufficient knowledge of HAMs.

Methods:

A cross-sectional study was conducted using a self-administered questionnaire distributed to all nurses involved in medication administration at Mansoura University Children's Hospital. The questionnaire covered identification of HAMs, storage, administration protocols, and error prevention strategies. Data was collected from [February to October 2025] and analyzed using descriptive statistics and logistic regression.

Setting:

Mansoura University Children's Hospital, Mansoura, Egypt.

Participants:

All registered nurses working in the hospital and involved in medication administration.

Outcome Measures:

  • Primary: Level of knowledge about HAMs (scored as sufficient/insufficient).
  • Secondary: Factors associated with sufficient knowledge (e.g., years of experience, training).

Study Type

Observational

Enrollment (Actual)

335

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Al Mansurah, Egypt
        • Mansoura University Children's Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

All registered nurses working at Mansoura University Children's Hospital who are involved in medication administration. The study includes nurses from various departments with at least 6 months of experience. This hospital-wide audit targets frontline healthcare providers responsible for high-alert medication handling in a tertiary pediatric setting.

Description

Inclusion Criteria:

  • - Registered nurses working at Mansoura University Children's Hospital.
  • Involved in medication administration.
  • At least 6 months of experience in the hospital.

Exclusion Criteria:

  • Non-nursing staff.
  • Nurses not involved in direct patient care or medication administration.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Proportion of nurses with sufficient knowledge of high-alert medications
Time Frame: February 2025 to October 2025
Percentage of nurses scoring ≥70% on the questionnaire assessing knowledge of high-alert medications (identification, administration, storage, and error prevention).
February 2025 to October 2025

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Factors associated with sufficient knowledge of high-alert medications
Time Frame: February 2025 to October 2025
Identification of factors (e.g., years of experience, training, department) associated with scoring ≥70% on the knowledge questionnaire using multivariate logistic regression.
February 2025 to October 2025

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Omar Hamdy

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 12, 2025

Primary Completion (Actual)

September 12, 2025

Study Completion (Actual)

September 12, 2025

Study Registration Dates

First Submitted

November 17, 2025

First Submitted That Met QC Criteria

November 17, 2025

First Posted (Actual)

November 21, 2025

Study Record Updates

Last Update Posted (Actual)

November 21, 2025

Last Update Submitted That Met QC Criteria

November 17, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • R.25.01.3028

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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