Knowledge About the Administration and Regulation of High Alert Medications Among Nurses in Mansoura University Children's Hospital: A Hospital-wide Audit (HAM-Audit)

Pediatric Medication Safety Revolution: Auditing Nurses' Knowledge on High-Alert Drugs

This study checks how well nurses at Mansoura University Children's Hospital know about high-alert medications (HAMs). These are drugs that can cause serious harm if given incorrectly. We used a questionnaire to assess their knowledge and identify any gaps. The goal is to improve training and reduce medication errors in the hospital.

Study Overview

• Status: Completed
• Conditions: Nurses' Knowledge of High-alert Medications in Pediatric Care

Detailed Description

Background:

Medication errors (MEs) are a major cause of patient harm, especially in pediatric settings. High-alert medications (HAMs) are drugs that carry a heightened risk of causing significant patient harm when used in error. Nurses play a critical role in the safe administration of HAMs. This hospital-wide audit aims to evaluate nurses' knowledge regarding the administration and regulation of HAMs at Mansoura University Children's Hospital.

Objectives:

1. To assess the level of knowledge about HAMs among nurses.
2. To identify factors associated with sufficient knowledge of HAMs.

Methods:

A cross-sectional study was conducted using a self-administered questionnaire distributed to all nurses involved in medication administration at Mansoura University Children's Hospital. The questionnaire covered identification of HAMs, storage, administration protocols, and error prevention strategies. Data was collected from [February to October 2025] and analyzed using descriptive statistics and logistic regression.

Setting:

Mansoura University Children's Hospital, Mansoura, Egypt.

Participants:

All registered nurses working in the hospital and involved in medication administration.

Outcome Measures:

• Primary: Level of knowledge about HAMs (scored as sufficient/insufficient).
• Secondary: Factors associated with sufficient knowledge (e.g., years of experience, training).

• Study Type: Observational
• Enrollment (Actual): 335

Contacts and Locations

Study Locations

• Egypt
  • Al Mansurah, Egypt
    • Mansoura University Children's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

All registered nurses working at Mansoura University Children's Hospital who are involved in medication administration. The study includes nurses from various departments with at least 6 months of experience. This hospital-wide audit targets frontline healthcare providers responsible for high-alert medication handling in a tertiary pediatric setting.

Description

Inclusion Criteria:

• - Registered nurses working at Mansoura University Children's Hospital.
• Involved in medication administration.
• At least 6 months of experience in the hospital.

Exclusion Criteria:

• Non-nursing staff.
• Nurses not involved in direct patient care or medication administration.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Proportion of nurses with sufficient knowledge of high-alert medications	Percentage of nurses scoring ≥70% on the questionnaire assessing knowledge of high-alert medications (identification, administration, storage, and error prevention).	February 2025 to October 2025

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Factors associated with sufficient knowledge of high-alert medications	Identification of factors (e.g., years of experience, training, department) associated with scoring ≥70% on the knowledge questionnaire using multivariate logistic regression.	February 2025 to October 2025

Collaborators and Investigators

• Sponsor: Omar Hamdy

Study record dates

Study Major Dates

• Study Start (Actual): February 12, 2025
• Primary Completion (Actual): September 12, 2025
• Study Completion (Actual): September 12, 2025

Study Registration Dates

• First Submitted: November 17, 2025
• First Submitted That Met QC Criteria: November 17, 2025
• First Posted (Actual): November 21, 2025

Study Record Updates

• Last Update Posted (Actual): November 21, 2025
• Last Update Submitted That Met QC Criteria: November 17, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Keywords: medication errors; nurses knowledge; high-alert medications
• Other Study ID Numbers: R.25.01.3028

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No