Patient-Specific 3D Action Observation Training in Parkinson's Disease

Examining the Effect of Action Observation Training Using Patient-Specific 3D Records in Parkinson's Patients

Although studies exist demonstrating the effects of single-session action observation training on bradykinesia in patients with Parkinson's disease, research investigating the long-term application of such training remains limited. Furthermore, the broader literature indicates that action observation training has typically been conducted in simulated environments or by using recordings obtained from healthy individuals. The aim of the present study is to examine the effects of action observation training, delivered in a fully immersive virtual reality environment using each patient's own 3D motion recordings, on bradykinesia and other disease-related parameters.

Study Overview

• Status: Recruiting
• Conditions: Parkinson Disease; Virtual Reality; Immersive Virtual Reality; Action Obervation Training; 3d Recording
• Intervention / Treatment: Other: Patient-Specific VR Action Observation Training; Other: Healthy-Model VR Action Observation Training

Detailed Description

Action observation training has been applied across diverse populations to improve performance and treat pathological conditions. Considering that bradykinesia tends to manifest more prominently in rhythmic movements, studies in healthy individuals have shown that merely observing rhythmic actions can influence spontaneous finger movement speed and lead to changes in motor performance, thereby paving the way for the use of action observation in addressing bradykinesia. In a study investigating the effects of action observation in patients with Parkinson's disease, observing fast rhythmic finger movements was reported to increase spontaneous finger movement speed, and compared with acoustic training, the effect of action observation persisted longer over time. Research on imagery through action observation further indicates that immersive virtual reality headsets, compared to monitor screens, facilitate the development of more distinct spatial rhythmic patterns in the brain. This evidence supports the use of fully immersive VR headsets instead of non-immersive monitor-based systems in action observation training.

• Study Type: Interventional
• Enrollment (Estimated): 24
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Enes T Benli, Ph.D; Phone Number: +905387359268; Email: enestayyipbenli@gmail.com

Study Locations

• Turkey (Türkiye)
  • Bolu
    • Bolu, Bolu, Turkey (Türkiye), 14100
      • Recruiting
      • Abant Izzet Baysal University Faculty of Health Science
      • Contact: ENES T Benli; Phone Number: +905387359268; Email: enestayyipbenli@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Voluntary agreement to participate in the study
• Clinical diagnosis of Parkinson's disease confirmed by a neurologist
• Ongoing treatment with antiparkinsonian medication
• Hoehn and Yahr (H-Y) stage ≤ 3
• Ability to walk independently

Exclusion Criteria:

• Presence of additional neurological disorders other than Parkinson's disease
• Change in medication dosage within the past month
• Score of ≥ 10 on the Simulator Sickness Questionnaire
• Presence of amblyopia, strabismus, or pathologies impairing focus, depth perception, or normal 3D vision
• Failure on the butterfly test of the Titmus stereotest (greater than 3,552 seconds of arc)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Patient-Specific VR Group; Participants will undergo action observation training delivered in immersive virtual reality using their own 3D motion recordings.	Other: Patient-Specific VR Action Observation Training; Participants will receive immersive VR action observation training using their own 3D motion recordings captured with an Insta360 camera (Arashi Vision Inc., Shenzhen, China). In Parkinson's patients, only the initial movement sequences without bradykinetic slowing will be selected, and these will be extended to the desired duration using loop playback or ping-pong loop playback in the device's proprietary software. The action observation protocol will consist of the following one-minute tasks: (1) total finger abduction and adduction, (2) fist making and opening, (3) wrist flexion and extension, (4) forearm pronation and supination, and (5) rhythmic striking of the dorsal and palmar surfaces of one hand against the palm of the other. A 1-minute rest will be given between each video. Training will be provided in addition to conventional therapy (35 minutes, 3 days per week for 6 weeks) tailored to individual needs.
Active Comparator: Healthy-Model VR Group; Participants will undergo action observation training delivered in immersive virtual reality using 3D recordings obtained from healthy individuals performing the same actions.	Other: Healthy-Model VR Action Observation Training; Participants will receive immersive VR action observation training using 3D video recordings of the same activities performed by healthy individuals, captured with an Insta360 camera (Arashi Vision Inc., Shenzhen, China). Recordings will not require editing or adjustments. The action observation protocol will consist of the same one-minute tasks: (1) total finger abduction and adduction, (2) fist making and opening, (3) wrist flexion and extension, (4) forearm pronation and supination, and (5) rhythmic striking of the dorsal and palmar surfaces of one hand against the palm of the other. A 1-minute rest will be given between each video. Training will be provided in addition to conventional therapy (35 minutes, 3 days per week for 6 weeks) tailored to individual needs.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Spontaneous Movement Rate (SMR	In this study, kinematic parameters of finger movements will be determined from video recordings. A commercial motion analysis software will be used to extract the coordinates of manually marked tracking points, which will then be transferred into tabular form for analysis. To improve the accuracy of marking and tracking, participants will wear fingertip gloves in different colors.The spontaneous movement rate will be calculated from video-recorded finger-tapping tasks. Each cycle consists of a touch duration (TD) and an inter-tapping interval (ITI). SMR will be defined as the inverse of the total duration of one tapping cycle (TD + ITI) and expressed in Hertz (Hz).	At baseline and after completion of 6-week intervention period

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Unified Parkinson's Disease Rating Scale (UPDRS)	Disease severity will be assessed using the Unified Parkinson's Disease Rating Scale (UPDRS), the most commonly used valid and reliable instrument for evaluating impairments and disabilities in Parkinson's disease.	At baseline and after completion of 6-week intervention period
Nine-Hole Peg Test (NHPT)	The Nine-Hole Peg Test is a performance-based assessment of manual dexterity. Before the test begins, participants will be instructed and shown how to perform the task once. They will then be asked to pick up the pegs one by one, place them into the holes, and after filling all holes, remove them one by one and place them back into the container.	At baseline and after completion of 6-week intervention period
Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH)	The Disabilities of the Arm, Shoulder and Hand Questionnaire is a 30-item instrument used to evaluate upper extremity function and the impact of upper limb problems on daily activities. The first 21 items assess the degree of difficulty in performing various daily activities with the dominant extremity over the past week. The next 5 items assess the severity of pain, numbness, and weakness experienced during activities. The final 4 items evaluate the impact of upper limb pathology on sleep, work, social life, and psychological status.	At baseline and after completion of 6-week intervention period
Parkinson's Disease Questionnaire (PDQ-8)	Quality of life in Parkinson's disease will be assessed using the Parkinson's Disease Questionnaire (PDQ-39), a disease-specific instrument consisting of 39 items across eight domains: mobility (10 items), activities of daily living (6 items), emotional well-being (6 items), stigma (3 items), social support (3 items), cognition (4 items), communication (3 items), and bodily discomfort (4 items). To reduce participant burden, the PDQ-8, a short form including one representative item from each domain, may also be used. Items in the PDQ-8 evaluate the patient's status over the past month and are scored on a 5-point scale ranging from 0 (never) to 4 (always).	At baseline and after completion of 6-week intervention period
Intrinsic Motivation Inventory (IMI)	The Intrinsic Motivation Inventory (IMI) is a multidimensional questionnaire used to assess participants' motivation and satisfaction while performing a given activity. It evaluates several domains, including interest/enjoyment, perceived competence, pressure/tension, perceived choice, and value/usefulness.	After completion of 6-week intervention period

Collaborators and Investigators

• Sponsor: Abant Izzet Baysal University

Study record dates

Study Major Dates

• Study Start (Actual): December 15, 2025
• Primary Completion (Estimated): July 15, 2027
• Study Completion (Estimated): August 15, 2027

Study Registration Dates

• First Submitted: October 2, 2025
• First Submitted That Met QC Criteria: November 18, 2025
• First Posted (Actual): November 26, 2025

Study Record Updates

• Last Update Posted (Actual): May 11, 2026
• Last Update Submitted That Met QC Criteria: May 6, 2026
• Last Verified: October 1, 2025

More Information

Terms related to this study

• Keywords: Parkinson; Virtual reality
• Additional Relevant MeSH Terms: Synucleinopathies; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurodegenerative Diseases; Movement Disorders; Parkinsonian Disorders; Basal Ganglia Diseases; Parkinson Disease
• Other Study ID Numbers: AIBU-FTR-BENLI-009

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: No, individual participant data (IPD) will not be made available to other researchers.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No