Total Knee Replacement Under Spinal Anesthesia, Comparison of Postoperative Recovery Versus General Anesthesia (PTG-RachiVsAG)

December 8, 2025 updated by: University Hospital, Strasbourg, France

Total Knee Replacement Under Spinal Anesthesia, Comparison of Postoperative Recovery Versus General Anesthesia: A Retrospective Single-Center Observational Comparative Superiority Study

Intraoperative anesthetic management for total knee replacement (TKR) can be performed under general or spinal anesthesia. These two techniques have their own characteristics and may impact postoperative recovery differently. However, there are no studies in the literature analyzing postoperative functional recovery after TKR surgery according to the type of anesthesia. The objective of this study is to compare postoperative recovery, assessed by the QoR-15F score, in patients undergoing TKR under spinal anesthesia versus surgery under general anesthesia.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
      • Strasbourg, France, 67091
        • Recruiting
        • Service d'Anesthésiologie - Réanimation Chirurgicale - CHU de Strasbourg - France
        • Contact:
        • Principal Investigator:
          • Eric NOLL, MD, PhD
        • Sub-Investigator:
          • Thomas PERRIN, MD
        • Sub-Investigator:
          • Julien POTTECHER, MD, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult subject having total knee replacement surgery between January 1, 2020 and June 30, 2023

Description

Inclusion Criteria:

  • Male or female, 18 years of age or older (no upper age limit)
  • Underwent total knee replacement surgery between January 1, 2020 and June 30, 2023
  • Assessed using the QoR-15F score

Exclusion Criteria:

  • Subject (and/or their legal representative, if applicable) who expressed their opposition to the reuse of their data for scientific research purposes.
  • Revision, emergency, oncological, bilateral, or septic surgery

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
QoR-15F score
Time Frame: at Day 1, Day3, Day 14, and Day 28 postoperatively
at Day 1, Day3, Day 14, and Day 28 postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Strasbourg, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 3, 2024

Primary Completion (Estimated)

December 3, 2025

Study Completion (Estimated)

December 3, 2025

Study Registration Dates

First Submitted

March 28, 2025

First Submitted That Met QC Criteria

December 8, 2025

First Posted (Actual)

December 10, 2025

Study Record Updates

Last Update Posted (Actual)

December 10, 2025

Last Update Submitted That Met QC Criteria

December 8, 2025

Last Verified

March 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 9305

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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