Endodontic Posts Using the CAD/CAM Digital Method.

Study of the Survival and Success of Endodontic Posts Exclusively Using the CAD/CAM Digital Method After 5 Years of Intraoral Use

This study investigates the survival and success rates of endodontic posts exclusively fabricated using the CAD/CAM digital method over a period of 5 years of intraoral use. The objective is to evaluate the efficacy and long-term outcomes of the digital approach compared to traditional techniques, aiming to determine the reliability and precision of CAD/CAM technology in the fabrication of endodontic post restorations.

Study Overview

• Status: Active, not recruiting
• Conditions: Tooth Restoration; Endodontic Treatment
• Intervention / Treatment: Device: Lithium Disilicate CAD/CAM Post; Device: Active Comparator: Polymer-Based CAD/CAM Posts

Detailed Description

This clinical study aims to evaluate the survival and success rates of endodontic posts exclusively fabricated using the CAD/CAM digital method over a period of 5 years of intraoral use. The study focuses on the utilization of advanced digital technology for the design and fabrication of endodontic posts, which replaces traditional impression-taking and analog methods.

Participants in the study will undergo treatment where digital intraoral scanners will capture the post-space anatomy, and CAD software will be used to design custom posts that are then milled using CAM technology. The fabricated posts will be evaluated for fit, stability, and clinical performance over a prolonged period.

The primary outcome measures include the survival rate of the posts (absence of dislodgement or failure) and the success rate, which incorporates the functional and aesthetic integration of the post with the surrounding dental structures. Secondary outcomes will assess the incidence of complications such as root fractures, debonding, and endodontic failure.

This study distinguishes itself by exclusively using the digital CAD/CAM approach, with no involvement of traditional methods, ensuring precision and consistency in post fabrication. It aims to provide comprehensive data on the effectiveness and reliability of CAD/CAM technology for endodontic applications, offering insights that could influence clinical protocols and materials used in restorative dentistry

• Study Type: Interventional
• Enrollment (Estimated): 80
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Greece
  • Thessaloniki, Greece, 54124
    • School of Dentisty, Aristotle University of Thessaloniki

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Participants aged 18 to 70 years
• Patients requiring endodontic treatment with post placement
• Individuals with adequate tooth structure to support a post restoration
• Patients who consent to participate and commit to follow-up visits for a period of 5 years
• Good overall oral health with no active periodontal disease

Exclusion Criteria:

• Patients with systemic conditions that could affect oral health or healing (e.g., uncontrolled diabetes or immune-compromising diseases)
• Individuals with severe periodontal disease or compromised tooth structure unsuitable for post placement
• Pregnant or breastfeeding women
• Patients unwilling or unable to commit to the 5-year follow-up period
• Individuals with allergies or adverse reactions to dental materials used in the CAD/CAM process
• Minimum Age = 18 Years and Maximum Age = 70 Years

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental: Lithium Disilicate CAD/CAM Posts; Patients in this arm receive custom CAD/CAM posts fabricated from lithium disilicate. All posts are designed, milled, and cemented using standardized preparation, adhesive, and cementation protocols. Clinical follow-up evaluates post survival, success rates, biological response, and the need for repair or replacement over time.	Device: Lithium Disilicate CAD/CAM Post; Patients in this arm receive custom CAD/CAM posts fabricated from lithium disilicate. All posts are designed, milled, and cemented using standardized preparation, adhesive, and cementation protocols. Clinical follow-up evaluates post survival, success rates, biological response, and the need for repair or replacement over time.
Active Comparator: Active Comparator: Polymer-Based CAD/CAM Posts; Patients in this arm receive custom CAD/CAM posts fabricated from high-performance polymer materials. Posts are manufactured and cemented using the same standardized clinical workflow applied in Arm 1. This arm allows comparison of survival, success rates, functional stability, and biological outcomes relative to lithium disilicate CAD/CAM posts.	Device: Active Comparator: Polymer-Based CAD/CAM Posts; Patients in this arm receive custom CAD/CAM posts fabricated from high-performance polymer materials. Posts are manufactured and cemented using the same standardized clinical workflow applied in Arm 1. This arm allows comparison of survival, success rates, functional stability, and biological outcomes relative to lithium disilicate CAD/CAM posts.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Survival Rate of CAD/CAM Endodontic Posts	The primary outcome measure is the survival rate of endodontic posts fabricated using the CAD/CAM digital method. Survival is defined as the post remaining in situ without any signs of dislodgement, root fracture, or clinical failure necessitating replacement. Posts will be evaluated periodically to monitor their clinical performance and integrity, ensuring that no adverse events such as post loosening or tooth failure occur	Assessed over a period of 5 years post-placement

Collaborators and Investigators

• Sponsor: Aristotle University Of Thessaloniki
• Investigators: Study Chair: Kosmas Tolidis, Professor, School of Dentistry, Aristotle University of Thessaloniki

Study record dates

Study Major Dates

• Study Start (Actual): November 30, 2023
• Primary Completion (Estimated): November 30, 2028
• Study Completion (Estimated): November 30, 2029

Study Registration Dates

• First Submitted: December 9, 2025
• First Submitted That Met QC Criteria: December 9, 2025
• First Posted (Estimated): December 22, 2025

Study Record Updates

• Last Update Posted (Actual): December 23, 2025
• Last Update Submitted That Met QC Criteria: December 22, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: CAD/CAM; intraoral Scanners; post fabrication; endodontic posts
• Other Study ID Numbers: 203/30-11-2023

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The individual participant data (IPD) from this study will not be shared due to privacy and confidentiality concerns. The data collected includes sensitive patient information, and sharing it publicly may compromise participant anonymity and violate ethical guidelines. Furthermore, the study does not have the necessary infrastructure in place to ensure secure and compliant sharing of IPD with other researchers.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No