The Taiwan OSA Study (TOSA)

December 11, 2025 updated by: Wan-Ju Cheng, China Medical University Hospital

Clinical Features of Obstructive Sleep Apnea Patients With Different Phenotypes

We will prospectively recruit 7000 OSA patients referred to the sleep center or China Medical University Hospital between 2020 and 2027. Polysomnographic (PSG) study data, clinical features, and health data from the National Health Insurance Research Database will be linked. Endotypic traits will be determined by PSG study parameters. The associations between clinical features, endotypic traits, and health outcome will be examined. Some patients will be invited to receive lung function tests, blood serum tests, blood gas tests, and cognitive function tests.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

7000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Wan-Ju Cheng, Doctor
  • Phone Number: +1872 +886422052121
  • Email: s871065@gmail.com

Study Locations

  • Taiwan
    • Taiwan
      • Taichung, Taiwan, Taiwan, 404
        • Recruiting
        • China Medical University Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Patients who are referred to China Medical University Hospital sleep center by physicians

Description

Inclusion Criteria:

  • patients who are referred to China Medical University Hospital sleep center by physicians

Exclusion Criteria:

-Individuals unable to complete at least 6 hours of PSG examination

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Cohort Label

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Health outcome
Time Frame: Within 20 years from the date of the PSG examination
Registered diagnosis in the National Health Insurance Database
Within 20 years from the date of the PSG examination

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sleep quality
Time Frame: Baseline
Pittsburgh Sleep Quality Index (PSQI) ranges from 0 (better) to 21 (worse).
Baseline
Daytime sleepiness
Time Frame: Baseline
Epworth Sleepiness Scale ranges from 0 (better) to 24 (worse)
Baseline
Sleep quality
Time Frame: Baseline
Basic Nordic Sleep Questionnaire,a higher Basic Nordic Sleep Questionnaire score indicates worse outcomes
Baseline
Sleep quality
Time Frame: Baseline
Munich Chronotype Questionnaire
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

China Medical University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 10, 2020

Primary Completion (Estimated)

February 28, 2032

Study Completion (Estimated)

February 28, 2032

Study Registration Dates

First Submitted

November 25, 2025

First Submitted That Met QC Criteria

December 11, 2025

First Posted (Actual)

December 24, 2025

Study Record Updates

Last Update Posted (Actual)

December 24, 2025

Last Update Submitted That Met QC Criteria

December 11, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CMUH109-REC3-018

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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