Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow (VASC-STIM)

March 9, 2026 updated by: Centre Hospitalier Metropole Savoie

Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow - a Pilot Study

The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers. The main question it aims to answer is:

Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) inducing the most significant hyperaemic response in volunteers.

Participants will attend to one visit ( 1h30) , 6 protocol of stimulation will be tested on his arm . If his agree, an optionnal measure will be made during another visit. During this optionnal visit, two modalities of intensity adjustment will be tested in regard of the result of the first part of the study.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Subject aged 18 years or older
  • Having freely given written consent, after being informed of the purpose of the study, its conduct and its risks.
  • Affiliated with a social security scheme

Exclusion Criteria:

  • Persons with pacemakers or any other implantable electrical devices,
  • Pregnant women
  • Suffering from dermatological conditions or muscle/skin lesions on the arms and forearms.
  • Participant unable to give free and informed consent.
  • Participant unable to comply with the specific procedures of the study.
  • Participant deprived of liberty or benefiting from legal protection measures.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: experimental group
transcutaneous electrical nerve stimulation
Other: transcutaneous electrical nerve stimulation
transcutaneous electrical nerve stimulation on arm. 6 different protocol will be apply testing different modality of frequency and positionnement of electrodes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
stimulation parameters that induce the most significant hyperaemic response
Time Frame: from enrollment to the end of the procedure (1h30)
Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) that induce the most significant hyperaemic response in volunteers.
from enrollment to the end of the procedure (1h30)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assess the score on a scale of disconfort level during stimulation for each condition
Time Frame: during testing procedure
The outcome will be assess using a visual analogic disconfort scale ranging from 0 (no disconfort) to 10 (the highest disconfort imaginable).
during testing procedure
Compare stimulation intensities between each condition
Time Frame: during testing procedure
during testing procedure
Compare muscle metabolic demand between each condition
Time Frame: during testing procedure
during testing procedure

Other Outcome Measures

Outcome Measure
Time Frame
ancillary : Compare blood flow kinetics during long-term stimulation (1 hour) according to the modalities of intensity adjustment over time (no adjustment vs. adjustment).
Time Frame: during testing procedure (second visit)
during testing procedure (second visit)
ancillary : Compare the comfort reported by participants during long-term stimulation based on the methods used to adjust intensity over time (no adjustment vs. adjustment).
Time Frame: during testing procedure (second visit)
during testing procedure (second visit)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Metropole Savoie

Collaborators

Laboratoire Interuniversitaire de Biologie de la Motricité
Université Savoie Mont Blanc

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 4, 2026

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

August 1, 2026

Study Registration Dates

First Submitted

December 30, 2025

First Submitted That Met QC Criteria

January 12, 2026

First Posted (Actual)

January 21, 2026

Study Record Updates

Last Update Posted (Actual)

March 10, 2026

Last Update Submitted That Met QC Criteria

March 9, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CHMS25010
  • 2025-A02335-44 (Other Identifier: RCB)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

exploratory research at this time

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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