Effect of Topical Argan Oil on Healing After Laser Depigmentation.

January 14, 2026 updated by: Ghada Adayil

Comparative Evaluation of Argan Oil as a Post-Operative Agent Versus Placebo Following Laser Gingival Depigmentation: A Randomized Controlled Clinical Trial

Effect of Argan oil vs placebo on healing after laser depigmentation

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Evaluate the effect of Argan oil vs. placebo on post-operative healing after laser depigmentation. as well as Compare pain levels (VAS score), gingival pigmentation recurrence, and patient satisfaction between groups at predetermined follow-up intervals.

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypt
        • Faculty of Dentistry, Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Patients aged 18-40 with moderate/severe physiological gingival pigmentation
  • Good general and periodontal health.

Exclusion Criteria:

  • Systemic diseases affecting healing (e.g., uncontrolled diabetes).
  • Smokers or tobacco chewers.
  • Pregnant/lactating women.
  • Previous depigmentation procedures in the last 2 years.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Topical Argan Oil
Applied post-laser depigmentation
Procedure: Laser Depigmentation

Laser protocol:

Diode laser, wavelength 810-980 nm, continuous mode, initiated fiber tip 400 µm, power 1.5-2 W.
Placebo Comparator: Reference placebo
Identical placebo formulation
Procedure: Laser Depigmentation

Laser protocol:

Diode laser, wavelength 810-980 nm, continuous mode, initiated fiber tip 400 µm, power 1.5-2 W.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Effect of Argan oil
Time Frame: 14 days
Evaluate the effect of Argan oil vs. placebo on post-operative Gingival healing
14 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Visual Analog Scale (VAS)
Time Frame: 14 days
Compare pain levels (VAS score) , gingival pigmentation recurrence, and patient satisfaction between groups.
14 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ghada Adayil

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 29, 2025

Primary Completion (Actual)

December 22, 2025

Study Completion (Actual)

January 10, 2026

Study Registration Dates

First Submitted

January 14, 2026

First Submitted That Met QC Criteria

January 14, 2026

First Posted (Actual)

January 22, 2026

Study Record Updates

Last Update Posted (Actual)

January 22, 2026

Last Update Submitted That Met QC Criteria

January 14, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 28-10-2025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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