Evaluatıon of TREM-1, MMP-8 and TIMP-1 Levels in Perı-Implant Crevicular Fluıd of Perı-Implanted Indıvıduals

February 5, 2026 updated by: Veli Özgen Öztürk, Aydin Adnan Menderes University
The aim of this study was to evaluate the relationship between Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1), Matrix Metalloproteinases-8 (MMP-8) and Tissue Inhibitors of Metalloproteinases-1 (TIMP-1) levels in peri-implant crevicular fluid (PICF) in peri-implantitis patients.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The aim of this study was to evaluate the relationship between TREM-1, MMP-8 and TIMP-1 levels in peri-implant crevicular fluid (PICF) in patients with peri-implantitis, and the correlation of these markers with clinical periodontal parameters.

Study Type

Observational

Enrollment (Actual)

54

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

All patients had at least one implant, and this implant had been in place for at least one year since the implant-supported prosthesis was made.

Description

Inclusion Criteria:

  • Systemically healthy
  • Pregnancy or lactation

Exclusion Criteria:

  • osteoporosis
  • rheumatoid arthritis
  • autoimmune disease
  • diabetes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Peri-implantitis
Peri-implantitis is defined as bleeding on probing, suppuration, increased probing depth, clinical attachment loss, and radiographic bone loss
Other: Collection of PICF samples
TREM-1, MMP-8 and TIPM-1 levels reseach in PICF samples
Peri-implant Health
Peri-implant health is characterized by the absence of bleeding on probing, erythema, swelling, and suppuration in the peri-implant region
Other: Collection of PICF samples
TREM-1, MMP-8 and TIPM-1 levels reseach in PICF samples

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
TREM-1, MMP-8 and TIMP-1 levels in PICF samples
Time Frame: 1 month
TREM-1, MMP-8, and TIMP-1 levels in PICF samples were measured by ELISA method
1 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Aydin Adnan Menderes University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2023

Primary Completion (Actual)

December 15, 2023

Study Completion (Actual)

May 20, 2024

Study Registration Dates

First Submitted

January 25, 2026

First Submitted That Met QC Criteria

January 25, 2026

First Posted (Actual)

February 2, 2026

Study Record Updates

Last Update Posted (Actual)

February 9, 2026

Last Update Submitted That Met QC Criteria

February 5, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • BAP-23003

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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