Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females

February 25, 2026 updated by: Ramiz ARABACI, Uludag University

The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.

The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.

Recreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.

This study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

235

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • absent of lower body injuries that could impact testing;
  • were moderately physically active
  • did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.

Exclusion Criteria:

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Young Adult Participants Healthy Recreationally Active Adults
Male and Female Participant
Other: Physical Performance Assessment
Muscle Isokinetic Strength Testing, Leg Muscle Mass, and Aerobic and Anaerobic Performance Testing, Contermovement Jump

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Leg Muscle Mass-Related Physical Performance Measures
Time Frame: Baseline

Measurement tool: Bioelectrical Impedance Analyzer (InBody 270, Biospace Co., South Korea) Description: Segmental lower-limb muscle mass (kg) measured using multi-frequency bioelectrical impedance analysis.

Unit: kg Time Frame: Baseline (single assessment)
Baseline
Muscle Isokinetic Strength
Time Frame: Baseline

Measurement tool: Isokinetic dynamometer (Humac Norm, Computer Sports Medicine Inc., USA) Description: Peak torque of dominant leg knee flexors and extensors measured at 60°·s-¹ and normalized to body weight.

Unit: Nm·kg-¹ Time Frame: Baseline
Baseline
Anaerobic Power
Time Frame: Baseline

Measurement tool: Wingate Anaerobic Test performed on cycle ergometer (Wattbike WPM Model B, UK) Description: Relative peak anaerobic power calculated during 30-s Wingate test and normalized to body weight.

Unit: W·kg-¹ Time Frame: Baseline
Baseline
Countremovement Jump
Time Frame: Baseline

Measurement tool: SmartJump contact mat system (Fusion Sport, Queensland, Australia) Description: Vertical jump height measured during the Countermovement Jump test. Jump height is calculated automatically from flight time using the SmartJump performance measurement system.

Scale description: Countermovement Jump Height (centimeters). Typical physiological range in healthy young adults is approximately 10-60 cm.

Interpretation: Higher values indicate better lower-body explosive performance. Unit: cm Time Frame: Baseline (up to 8 weeks)
Baseline
Aerobic Capacity
Time Frame: Baseline

Measurement tool: Breath-by-breath metabolic gas analyzer (Cosmed Quark CPET) during Bruce treadmill protocol Description: Maximal oxygen consumption determined according to standard VO₂max criteria.

Unit: ml·kg-¹·min-¹ Time Frame: Baseline
Baseline
Muscle Isometric Strength
Time Frame: Baseline

Measurement tool: Leg dynamometer (Takei T.K.K. 5402, Takei Scientific Instruments, Japan) Description: Maximal voluntary isometric force normalized to body weight. Highest value of three trials recorded.

Unit: kg·kg-¹ Time Frame: Baseline
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Uludag University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 20, 2026

Primary Completion (Estimated)

June 5, 2026

Study Completion (Estimated)

August 15, 2026

Study Registration Dates

First Submitted

January 5, 2026

First Submitted That Met QC Criteria

February 25, 2026

First Posted (Actual)

February 27, 2026

Study Record Updates

Last Update Posted (Actual)

February 27, 2026

Last Update Submitted That Met QC Criteria

February 25, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • E-87914409-050.04-87583

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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