Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis

February 23, 2026 updated by: Mays Jaafar Soballah, University of Baghdad

Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis: A Case-Control Study

The current study primarily aims to evaluate the presence of T. parvum in periodontal health and disease, and its correlation with clinical parameters. Subgingival plaque samples will be collected using sterile paper points then the samples will be analyzed using quantitative polymerase chain reaction (qPCR) to detect T. parvum and estimate its relative amount in the biofilm. The results may help clarify the association between T. parvum and periodontitis.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

112

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Iraq
      • Baghdad, Iraq, 10047
        • Recruiting
        • College of Dentistry, University of Baghdad
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Study population involves those who are attending the clinics of Periodontics in the College of Dentistry / University of Baghdad, in Baghdad / Iraq, and seeking for periodontal treatment. Eligible patients according to the pre-defined inclusion and exclusion criteria who will be invited to participate in this study.

Description

Inclusion Criteria: include participants who have at least 20 teeth and diagnosed as generalized periodontitis.

Exclusion Criteria: participants meeting any of the following criteria were excluded: (1) undergoing orthodontic treatment; (2) having a history of antibiotic/nonsteroidal anti-inflammatory drugs use within the last three months; (3) having a history of valve replacement who need prophylactic antibiotic coverage; (4) pregnant or lactating women; (5) having a history periodontal therapy within the last six month.

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Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Periodontitis
Healthy periodontium

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Relative abundance of T. parvum in subgingival biofilm
Time Frame: At enrollment
Detection and relative abundance of T. parvum in subgingival biofilm measured by qPCR from subgingival plaque collected using sterile paper points
At enrollment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Baghdad

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

September 1, 2026

Study Registration Dates

First Submitted

February 23, 2026

First Submitted That Met QC Criteria

February 23, 2026

First Posted (Actual)

March 2, 2026

Study Record Updates

Last Update Posted (Actual)

March 2, 2026

Last Update Submitted That Met QC Criteria

February 23, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1111625

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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