Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder (TIPA)

March 9, 2026 updated by: Assistance Publique - Hôpitaux de Paris

Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior.

This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD.

Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:

  • A computerized learning task in which they respond to visual stimuli and receive feedback on their performance
  • Standardized questionnaires assessing psychological traits and cognitive functioning

The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics.

This research does not modify participants' medical care and involves no medication or invasive procedures.

By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

Alcohol Use Disorder (AUD) is associated with difficulties in decision-making and behavioral adaptation, particularly in situations involving uncertainty. Individual psychological traits may influence how people with AUD adjust their behavior when facing changing environments, but this relationship remains insufficiently understood.

This monocentric, non-interventional study aims to explore how individual traits influence adaptive processes in adults diagnosed with Alcohol Use Disorder.

Participants receiving usual care at Paul Brousse Hospital will attend a single experimental session lasting approximately 45 minutes. During this session, they will perform a computerized learning task designed to evaluate behavioral adaptation when task rules change unexpectedly. They will also complete standardized questionnaires assessing personality traits and cognitive functioning.

Behavioral performance during the task will be analyzed to measure adaptation to uncertainty and examined in relation to individual psychological characteristics.

The study does not involve medication, medical devices, or any modification of clinical care.

Study Type

Observational

Enrollment (Estimated)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients diagnosed with Alcohol Use Disorder (DSM-5) receiving outpatient care in the Psychiatry and Addiction Department

Description

Inclusion Criteria:

  • Adults aged 18 years or older
  • Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
  • No objection to participation in the study

Exclusion Criteria:

  • Diagnosed neurological disorder
  • Patient covered by State Medical Assistance (AME)
  • Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
  • Individuals deprived of liberty by judicial or administrative decision
  • Pregnant or breastfeeding women
  • Psychiatric disorders that could compromise proper study participation (excluding Alcohol Use Disorder)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Uncertainty Cost Index During Behavioral Adaptation Task
Time Frame: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)
Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.
At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation Between Uncertainty Cost Index and Psychometric Trait Scores
Time Frame: During the single study session (approximately 45 minutes)
Correlation coefficient between the uncertainty cost index and standardized psychometric test scores assessing personality traits and cognitive characteristics.
During the single study session (approximately 45 minutes)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assistance Publique - Hôpitaux de Paris

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 1, 2026

Primary Completion (Estimated)

April 1, 2026

Study Completion (Estimated)

April 1, 2027

Study Registration Dates

First Submitted

March 9, 2026

First Submitted That Met QC Criteria

March 9, 2026

First Posted (Actual)

March 13, 2026

Study Record Updates

Last Update Posted (Actual)

March 13, 2026

Last Update Submitted That Met QC Criteria

March 9, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • APHP251789
  • 2025-A02680-49 (Other Identifier: IDRCB)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Cognition Disorders

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cambodia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe