Effects of Exercise in Hemodialysis

March 30, 2026 updated by: Olynka Vega, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Effects of an Intradialytic Aerobic Exercise Program on Echocardiographic Findings in Patients With End-Stage Chronic Kidney Disease on Hemodialysis

Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis.

Materials and Methods Design: Open-label, single-center, quasi-experimental, single-group study with pre- and post-intervention measurements.

Study setting: the outpatient hemodialysis unit of the National Institute of Medical Sciences and Nutrition Salvador Zubirán.

Participants: Patients aged ≥18 years with chronic kidney disease on hemodialysis for at least three months, who are at their dry weight.

Procedures: An echocardiogram will be performed post-hemodialysis. Subsequently, patients will undergo a 30-minute intradialytic aerobic exercise program at submaximal intensity during the second hour of dialysis, three times per week for six months. At the end of the six-month period, a post-hemodialysis echocardiogram will be repeated.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

18

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Mexico
      • Mexico City, Mexico, 14080
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Adults aged ≥18 years
  • Receiving hemodialysis with a stable prescription for at least 3 months
  • At their prescribed dry weight
  • Provision of written informed consent

Exclusion Criteria:

  • Active cardiovascular disease within the past 3 months
  • Left ventricular ejection fraction <40%
  • Physical and/or cognitive impairment precluding exercise
  • Blood pressure >160/110 mmHg

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Patients on hemodialysis who will perform intradialytic aerobic exercise
Patients on hemodialysis who will perform intradialytic aerobic exercise for six months
Other: Intradialytic aerobic exercise program
A six-month intradialytic aerobic exercise program consisting of 30-minute sessions at submaximal intensity, performed during the second hour of hemodialysis three times per week.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Left ventricular ejection fraction
Time Frame: From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter
Left ventricular ejection fraction measured by transthoracic echocardiogram
From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2025

Primary Completion (Actual)

February 28, 2026

Study Completion (Actual)

March 15, 2026

Study Registration Dates

First Submitted

March 23, 2026

First Submitted That Met QC Criteria

March 30, 2026

First Posted (Actual)

April 2, 2026

Study Record Updates

Last Update Posted (Actual)

April 2, 2026

Last Update Submitted That Met QC Criteria

March 30, 2026

Last Verified

May 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • NMM-5123-24-25-1

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data (IPD) will not be shared in order to protect patient privacy and confidentiality and to comply with institutional and ethical regulations.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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