Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth (CGF-AT)

May 1, 2026 updated by: Ahmed Mohamed Sayed, Cairo University

Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth (A Case Series Study).

This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices.

Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth.

In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period.

The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Tooth autotransplantation is a well-established treatment modality for replacing missing teeth, particularly in young patients. However, the success of this procedure depends on multiple biological factors, including the preservation of the periodontal ligament, prevention of root resorption, and the potential for pulpal healing. In teeth with closed apices, pulpal revascularization is limited, which may negatively affect the long-term prognosis of the transplanted tooth.

Recently, platelet concentrates have gained increasing attention in regenerative dentistry due to their ability to enhance wound healing and tissue regeneration. Concentrated Growth Factors (CGF) represent an advanced generation of autologous platelet concentrates characterized by a dense fibrin matrix rich in growth factors such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF). These biological mediators play a critical role in angiogenesis, cell proliferation, and tissue regeneration.

The present study is designed to evaluate the clinical and radiographic outcomes of using CGF in autotransplantation of teeth with closed apices. The hypothesis is that the application of CGF at the recipient site may enhance healing, improve periodontal ligament regeneration, and reduce the incidence of complications such as inflammatory or replacement root resorption.

Eligible patients requiring tooth autotransplantation will be recruited according to predefined inclusion and exclusion criteria. The surgical procedure will be performed following standard protocols, with careful atraumatic extraction of the donor tooth and proper preparation of the recipient socket. CGF will be prepared from the patient's own blood using a standardized centrifugation protocol and applied to the recipient site prior to transplantation.

Postoperative follow-up will be conducted at specific intervals to assess both clinical and radiographic outcomes. Clinical evaluation will include parameters such as tooth mobility, periodontal probing depth, gingival condition, pain, and presence of infection or ankylosis. Radiographic assessment will include evaluation of bone healing, periodontal ligament space, root resorption (inflammatory or replacement), and periapical status.

Data will be collected and analyzed to compare outcomes and determine the effectiveness of CGF in improving the success rate of autotransplanted closed apex teeth. The results of this study may contribute to establishing evidence-based protocols for enhancing regenerative outcomes in tooth autotransplantation procedures.

Study Type

Interventional

Enrollment (Estimated)

7

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Elmanial
      • Cairo, Elmanial, Egypt
        • Faculty of oral and dental surgery cairo university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Donor Tooth : any 3rd molar tooth with fully developed roots (confirmed radiographically) and not functionally used (semi impacted, impacted but easily to be extracted, absence of the opposing etc…) .
  • Recipient Site : Recipient 1st or 2nd molar region (either upper or lower) with adequate bone volume to receive the auto transplanted tooth.
  • Oral Health: Good general oral hygiene and absence of active periodontal disease.
  • Systemic Health: patients with no contraindications for minor oral surgery.

Exclusion Criteria:

  • Poor Oral Hygiene: Presence of uncontrolled gingivitis or periodontitis.
  • Systemic Conditions: Patients with systemic diseases that may impair healing (e.g., uncontrolled diabetes, immunosuppression, bleeding disorders or bone metabolic diseases ).
  • Smoking: Active smokers or tobacco users.
  • Pregnancy or Lactation: Female patients who are pregnant or breastfeeding

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: CGF assisted auto transplantation
Participants in this arm will undergo autotransplantation of teeth with closed apices using a standardized surgical protocol. Concentrated Growth Factors (CGF) will be prepared from the patient's own blood and applied to the recipient site prior to placement of the donor tooth. The transplanted tooth will then be stabilized using an appropriate splinting technique. Patients will be followed up clinically and radiographically to assess healing outcomes and treatment success.
Procedure: closed apex teeth auto transplantation

In this study, autotransplantation of teeth with closed apices will be performed following standard surgical protocols. The donor tooth will be atraumatically extracted with maximum preservation of the periodontal ligament, and the recipient socket will be carefully prepared to receive the transplanted tooth.

In the intervention group, Concentrated Growth Factors (CGF) will be prepared from the patient's venous blood using a standardized centrifugation protocol. The obtained CGF will be applied to the recipient socket prior to placement of the donor tooth to enhance healing and promote tissue regeneration.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in Radiographic Bone Density at the Recipient Site
Time Frame: 6 months
Radiographic assessment of bone density at the recipient site will be performed using CBCT imaging to evaluate bone healing over time.
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Investigators

  • Study Director: Abdelmoez Mohamed El-Sharkawy, Associate Professor, Cairo University
  • Study Chair: Nesrine Mohammed Khairy, Professor of OMFS, Cairo University
  • Principal Investigator: Ahmed Mohamed Sayed, master degree, Cairo University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

July 1, 2027

Study Registration Dates

First Submitted

April 13, 2026

First Submitted That Met QC Criteria

April 13, 2026

First Posted (Actual)

April 20, 2026

Study Record Updates

Last Update Posted (Actual)

May 7, 2026

Last Update Submitted That Met QC Criteria

May 1, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • CU-OMFS-CGF-AT-01-2026

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Concentrated Growth Factor

Clinical Trials on closed apex teeth auto transplantation

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in South Korea

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe