Fertility Outcomes of Ovarian Tissue Cryopreservation

January 6, 2026 updated by: Chung Pui Wah Jacqueline, Chinese University of Hong Kong
With the advancement of assisted reproductive technology, more young cancer patients can consider having children. Ovaries and testes are important reproductive organs, and drugs, diseases, chemotherapy, and radiotherapy can all damage them. Reproductive preservation technology aims to protect patients whose reproductive ability has been damaged due to gonadotoxic drug therapy. Women can preserve their reproductive ability by freezing ovarian tissue cryopreservation so that they can have children in the future. Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital will be invited to participate in the study. Here, we aim to evaluate the outcomes after ovarian tissue cryopreservation.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Patients who have undergone or will undergo ovarian tissue cryopreservation in the Hong Kong Children's Hospital will be invited to join this study.

Description

Inclusion Criteria:

  • Patients aged from 0-18 years old and diagnosed with cancer
  • Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital
  • For patients under 18 years old, parents/legal guardians will be asked to further sign the consent for them.

Exclusion Criteria:

  • Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)
  • Male patients

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Surgical complications
Time Frame: 15 years
Surgical complications after ovarian tissue transplantation
15 years
Pregnancy rate
Time Frame: 15 years
Pregnancy rate after ovarian tissue transplantation
15 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chinese University of Hong Kong

Investigators

  • Principal Investigator: Pui Wah Jacqueline Chung, Chinese University of Hong Kong

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 15, 2026

Primary Completion (Estimated)

January 14, 2031

Study Completion (Estimated)

January 14, 2032

Study Registration Dates

First Submitted

January 6, 2026

First Submitted That Met QC Criteria

January 6, 2026

First Posted (Actual)

January 14, 2026

Study Record Updates

Last Update Posted (Actual)

January 14, 2026

Last Update Submitted That Met QC Criteria

January 6, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PAED-2025-067

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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